Drug profiles: generic names A-Z
Jerome Z. Litt, Neil H. Shear in Litt's Drug Eruption & Reaction Manual, 2017
Clinically important, potentially hazardous interactions with: acitretin, amoxicillin, ampicillin, antacids, bacampicillin, barbiturates, BCG vaccine, bismuth, calcium salts, carbamazepine, carbenicillin, cloxacillin, corticosteroids, coumarins, cyclosporine, dairy products, digoxin, ergotamine, kaolin, methotrexate, methoxyflurane, methysergide, mezlocillin, nafcillin, oral contraceptives, oral iron, oral typhoid vaccine, oxacillin, penicillins, phenindione, phenytoin, piperacillin, primidone, quinapril, retinoids, rifampin, St John’s wort, strontium ranelate, sucralfate, sulfonylureas, ticarcillin, tripotassium dicitratobismuthate, zinc
Successes, failures, and future prospects of prodrugs and their clinical impact
Published in Expert Opinion on Drug Discovery, 2019
Prodrugs have been developed for the treatment of microbial and protozoal infections. Bacampicillin and pivampicillin are ester penicillin-class prodrugs. Bacampicillin is 1ʹ- ethoxycarbonyloxyethyl ester prodrug of ampicillin and possesses no antimicrobial activity. During absorption, bacampicillin is rapidly and completely hydrolysed to ampicillin. Bacampicillin produces faster and higher serum concentrations of ampicillin than non-prodrug ampicillin [56]. Similarly, pivampicillin, the pivaloyloxymethyl ester prodrug of ampicillin has a higher absorption than ampicillin, but to a lesser extent [57,58].
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