Natural Products Structures and Analysis of the Cerrado Flora in Goiás
Luzia Valentina Modolo, Mary Ann Foglio in Brazilian Medicinal Plants, 2019
Finally, the targeting of bioprospecting studies has been possible, to some extent, due to the ethnobotanical knowledge that was concluded through this research, which identified the potential plant species linked to possible biotechnological development. Therefore, the group from the Laboratory of Natural Products and Organic Synthesis has developed its research in light of popular knowledge, as well as some plant species studied, such as, Hymenaea stigonocarpa Hayne (Fabaceae), Kielmeyera coriacea Mart. & Zucc (Calophyllaceae) and Annona coriacea Mart. (Annonaceae). Besides these, many other plant species have already been studied before. The main chemical and biological data of these plant species are presented herein. All plant species focused on in this chapter are listed in Table 11.1.
In Silico approach of soursop leaf for prediction of anticancer molecular target therapy
Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah in Medical Technology and Environmental Health, 2020
Annona muricata Linn (Annonaceae), commonly known as soursop or graviola, is in the Annonacea family. Some phytochemicals that are reported to have been isolated and characterized from various parts of the soursop plant are annonaceous acetogenins, lactones, isoquinoline alkaloids, tannis, coumarins, procyanidins, flavonoids, pentacyclic terpenoids saponins, p-coumaric acid, myristic acid, stepharine, reticulags, reticulins, ellicags, reticulins, and iced phytosterol (Chen et al. 2012, Liu et al. 2012). The first generation of annonaceous acetogenin mimetic (1, AA005) not only shows antitumor activity in some human cancer cells in vitro but also has high selectivity between normal cells and cancer cells (Qayed et al. 2015, Liang et al. 2009). Flavonoids have cytotoxic effects and selective apoptotic induction activity in vitro on squamous cell carcinoma HSC-2, submandibular gland carcinoma HSG. Tannins have a selective in vitro cytotoxic effect on human T cell lines, human oral squamous cell carcinomas, and salivary gland tumor cell lines rather than normal human gingival fibroblasts with activity inducing apoptosis (Watson & Preedy 2010, Chin 2009).
Ethanol extract of Annona squamosa L. improves the lipid profile in hyperlipidemia rats
Elida Zairina, Junaidi Khotib, Chrismawan Ardianto, Syed Azhar Syed Sulaiman, Charles D. Sands, Timothy E. Welty in Unity in Diversity and the Standardisation of Clinical Pharmacy Services, 2017
Annona squamosa L, belonging to the family of Annonaceae was identified to have various pharmacological activities such as antidiabetic, antiinflammation, analgesic, antimalarial, antioxidant, antimicrobial, and cytotoxic. Rofida & Firdiansyah (2015) showed that ethanol extract of the leaves can reduce the LDL-C level of hyperlipidemia rat at dose 0.25 mg/g B W. Thus, the aim of this study was to determine the effect of sugar apple peel ethanol extract on lipid profile, based on total cholesterol, triglyceride, and HDL-C parameters.
In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells
Published in Biomarkers, 2020
Aditi Venkatesh Naik, Krishnan Sellappan
Annona muricata L. is a flowering plant species within the family Annonaceae; widely found in the world’s tropical and subtropical regions, including parts of Africa, America and Asia (Anuragi et al.2016). All organs of this plant are used as ethnomedicine or phytochemical biomarkers to treat diverse diseases and maladies (Moghadamtousi et al.2015a). The plant components have been thoroughly studied till date for their valuable pharmacological properties, embodied by extracts or isolated compounds and were found most effective in the treatment of cancer along with other ailments (Gavamukulya et al.2017, Qazi et al.2018). According to literature, the leaves of A. muricata contain 117 isolates of secondary metabolites consisting primarily of alkaloids, phenolic compounds, megastigmanes and annonaceous acetogenins (Matsushige et al.2012, Coria-Téllez et al.2018).
Cytotoxic compounds from the leaves and stems of the endemic Thai plant Mitrephora sirikitiae
Published in Pharmaceutical Biology, 2020
Natthinee Anantachoke, Duangporn Lovacharaporn, Vichai Reutrakul, Sylvie Michel, Thomas Gaslonde, Pawinee Piyachaturawat, Kanoknetr Suksen, Samran Prabpai, Narong Nuntasaen
Various natural alkaloids are highly cytotoxic against many cancer cell lines via various different mechanisms of action, and many of these compounds have been developed into anticancer drugs such as vinblastine, vincristine, camptothecin, taxol, and ellipticine (Isah 2016; Iqbal et al. 2017). Liriodenine (5) and oxoputerine (11), aporphine alkaloids, have been reported in many plants of the family Annonaceae. These compounds exhibit cytotoxicity against cancer cell lines A549 (human lung carcinoma), BGC-823 (human gastric carcinoma), BEL-7402 (human liver carcinoma), HTC-8 (human colon carcinoma), and A2780 (human ovarian carcinoma) (Lu et al. 2011). Moreover, the anticancer property of liriodenine (5) is related to its anti-proliferative, apoptosis-inducing (Nakano et al. 2013), and topoisomerase II inhibitory effects (Woo et al. 1999). Liriodenine (5) also arrests the cell cycle by increasing in intracellular nitric oxide (NO) production, the overexpression of apoptosis-related proteins, p53 (Chen et al. 2012) and Bax, and the suppression of Bcl-2 (Nordin et al. 2015). However, there are no reports of the cytotoxicity of 6-methoxymarcanine A (15), a rare natural 1-azaanthraquinone alkaloid. However, it was revealed that marcanine A, a derivative of compound 15, exhibited cytotoxicity against various cancer cell lines A-549, HT-29, MCF-7, RPMI (melanoma), and U251 (human brain carcinoma) (Soonthornchareonnon et al. 1999).
Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton’s Lymphoma Ascites mediated tumours in Swiss albino mice
Published in Libyan Journal of Medicine, 2021
Aditi Venkatesh Naik, Shanti N. Dessai, Krishnan Sellappan
Entrenched in nature is all that is required to deal with the myriad infectious and non-infectious illnesses of ancient predominance and those of current emergence. An unprecedented spike in the number of illnesses and disorders caused by synthetic drugs has induced a switch over to conventional herbal medicine. Natural products extracted from plants; especially phytochemicals behave not only as therapeutic agents but, even more critically, in disease avoidance [1–3]. Amongst these is Annona muricata L. (Guanabana), belonging to family Annonaceae comprising roughly 135 genera and 2500 species. It exhibits a wide spectrum of ethno-therapeutic and efficacious properties toward cancer, accredited to various plant organs [4].
Related Knowledge Centers
- Monophyly
- Morphology
- Nectar
- Ovary
- Plastid
- Liana
- Plant Reproduction
- Gonochorism
- Molecular Phylogenetics
- Clade