In silico analysis of multi-target antimelasma aloe vera compound
Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah in Medical Technology and Environmental Health, 2020
Aloe (Xanthorrhoeaceae), which consists of about 400 species, is a perennial plant that has been used as traditional medicine for around 3,000 years. The most famous species is Aloe vera L., a plant without stems that grows up to 100 cm. The green leaves contain clear, colorless, and unpleasant ingredients as a gel. This gel is used in cosmetics, health drinks and beverages, and medicines. Substances containing aloe vera consist of 99.5% water and 0.5% active ingredients, including vitamins, polysaccharides, phenolic compounds, and organic acids. This gel has many biological activities, including anti-inflammatory, antiviral, antibacterial, anticancer, anti-diabetes, and anti-allergen activities. It also protects against radiation. The main phytochemicals in the gel are derivatives of anthraquinone and C-glucosilantrone: aloin A and B, emodin, desoksialoin, aloinosida B and C, and elgonica dimer A1. Aloesin, aloe emodin, and aloin A are reported to have antioxidant activity, whereas aloinoside B and C inhibit the activity of soluble epoxide hydrolase and phosphodiesterase-4D (Kim et al. 2017).
Emerging Highlights on Natural Prodrug Molecules with Multifarious Therapeutic Perspectives
Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi in Applied Pharmaceutical Practice and Nutraceuticals, 2021
Barbaloin (10-β-D-glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9-(10H)-anthracenore) is a main bioactive compound in Aloe Vera (Liliaceous plant family). It is a cactus-like plant that grows in hot, dry climates.40 The word “Aloe” derives from the Arabic word “Alloeh” meaning shining sour substance while “Vera” in Latin means true. There are more than 300 species of Aloe plant, but Aloe barbadensis species has the greatest medicinal properties.41. Barbaloin, also known as aloin, has diverse pharmacological effects that include anti-inflammatory, anti-oxidant, antitumor, purgative, and antiprotozoal effects.42. The purgative movement of barbaloin is triggered with the aid of Eubacterium sp., which converts barbaloin to aloe-emodin anthrone. Barbaloin inhibits the rat colonic Na+-K+-ATPase in vitro and improved paracellular permeability across the rat colonic mucosa in vivo.. Barbaloin pretreatment attenuates the myocardial ischemia–reperfusion injury via activation of AMP-activated protein kinase (AMPK) and restores infarction size.44.
Common Medicines from Herbs, Minerals and Animal Sources
Mehwish Iqbal in Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Aloe vera has a long-established history of providing a multitude of benefits for health and is amongst the most commonly utilised natural remedies all around the globe. Aloe barbadensis is the most famous and extensively utilised species. Aloe is originated from the Arabic term alloeh which means ‘bitter and glossy substance', while vera is derived from the Latin term ‘truth'. Aloe vera belongs to the family Liliaceae and is an extremely little stemmed or stemless xerophyte with peaked and elongated leaves in which great quantities of water are reserved in the tissues (Boudreau & Beland, 2006). In early Egypt, aloe vera was recognised as the ‘immortal plant' and has been consumed as a traditional medicinal herb in Roman, Greek, Arab, Korean, Egyptian, Japanese, Chinese and Indian cultures (Atherton, 1998; Grindlay & Reynolds, 1986).
Therapy for prevention and treatment of skin ionizing radiation damage: a review
Published in International Journal of Radiation Biology, 2019
José L. Soriano, Ana C. Calpena, Eliana B. Souto, Beatriz Clares
Non-steroidal anti-inflammatories, mainly trolamine, have been proposed by several authors (Table 3), but only one study seems to report real improvement (Abbas and Bensadoun 2012). Similarly, the use of plant derivatives such as Aloe vera or Calendula-based formulations have been inconclusive (Williams et al. 1996; Heggie et al. 2002; Pommier et al. 2004; Sharp et al. 2013), was also observed for sucralfate (Evensen et al. 2001; Wells et al. 2004). The use of Aloe vera is not recommended by the MASCC Skin Toxicity Study Group (Wong et al. 2013) because of lack of efficacy. Other prophylactic agents with topical application are antimicrobials (sulfadiazine), vasoconstrictors (epinephrine), acids (hyaluronic and ascorbic acids), and others agents (miscellaneous). The majority of published work ascertains that there is insufficient evidence to recommend specific topical agents. Indeed, in some cases like Calendula, their use is not recommended (Chan et al. 2012).
Pre-Exposure to Chronic Unpredictable Stress Suppresses the Chemopreventive Potential of Aloe Vera (Av) Leaf Gel Against 7,12-Dimethylbenz(a)anthracene (DMBA) Induced Carcinogenesis
Published in Nutrition and Cancer, 2019
Nida Suhail, Nayeem Bilal, Shirin Hasan, Naheed Banu
Aloe vera (Aloe barbadensis) is one of the herbal remedies known for its curative and therapeutic properties for various ailments. It possesses remarkable preventive and therapeutic potential against various cancers (11,12). The bioactive constituents of Aloe vera with chemopreventive potential such as lectin, aloin, barbaloin, aloe-emodin, and aloesin have shown to possess immune-potentiating, antimutagenic, antiproliferative, apoptosis-inducing, antioxidant, and antimetastatic potential (11–14). Different studies indicated antitumor activity for aloe vera gel in terms of reduced tumor burden, tumor yield, and tumor incidence (15,16). In addition to these effects, aloe vera gel has also shown chemopreventive and an antigenotoxic effect on benzo[α]pyrene-DNA adducts (17).
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
Published in Drug Delivery, 2022
Khaled M. Hosny, Waleed Y. Rizg, Eman Alfayez, Samar S. Elgebaly, Abdulmohsin J. Alamoudi, Raed I. Felimban, Hossam H. Tayeb, Rayan Y. Mushtaq, Awaji Y. Safhi, Majed Alharbi, Alshaimaa M. Almehmady
In this wok, we aimed to Enhancee the solubility and permeation of Finasteride through the formulation of the drug in the form of nanocubosomes using Design of Experiments (DoE) to develop the best optimized formulation of the delivery vehicle. In this study, oregano oil was used as an oil component in the formulation of nanocubosomes while also taking advantage of its benefits in promoting hair growth, treating some scalp problems such as Alopecia Areata, and having antimicrobial activity that will stop the Propionibacterium acnes, which is the main bacterial infection that affects the scalp in cases of Alopecia Areata. Furthermore, Aloe ferox gel was used as a carrier for the loaded nanocubosomes to ensure intimate contact between the loaded nanocubosomes and the scalpel due to its adhesiveness and viscosity. Aloe ferox also has several benefits in skin treatment as an antimicrobial, anti-inflammatory, and hair growth promoter.
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