Magnetocardiographic technology for human heart investigation
Waldemar Wójcik, Andrzej Smolarz in Information Technology in Medical Diagnostics, 2017
In cardiac electrophysiology it was found that almost any reason of pathology is related to the mechanism of ion current density variation across the cell membrane. This density of changing relative to normal—it is the first functional disorders that lead to pathology. Thus, MCG, which is sensitive mainly to the inside and to extracellular ion currents of the heart, provides more earlier diagnostic information than the known potential methods (Electrocardiography—ECG; Body Surface Potentials Mapping—BSPM). Moreover, data of potential measurement (ECG) contain no information about the shape of the current field source elements whose potentials are recorded on the body surface, while magnetometric data contain information about the spatial configuration of the ionic current in the heart.
Plasmodium falciparum
Eric S. Loker, Bruce V. Hofkin in Parasitology, 2015
Pathology Common symptoms include fever, chills and headache. Like other Plasmodium species, much of the pathology results from the release of inflammatory cellular debris and parasite waste products during lysis of infected erythrocytes. Because invasive stages use numerous receptors to attach and enter erythrocytes, they infect more cells and cause a much greater parasitemia than P. vivax, which uses only the Duffy antigen to bind erythrocytes. The sequestration of infected erythrocytes prevents infected cells from reaching the spleen, where they might be removed. Furthermore, sequestration can lead to blockage of circulation to the brain, resulting in hypoxia and the death of brain tissue known as cerebral malaria. This serious complication is exacerbated by inflammation initiated by the recognition of parasite molecules by TLRs on local antigen presenting cells, as described in Chapter 5 (page 177). Production of darkened urine (blackwater fever) is a hallmark of falciparum malaria.
All about Foreign Accent Syndrome
Jack Ryalls, Nick Miller in Foreign Accent Syndromes, 2014
One way to step beyond this is to search for the underlying cause of the speech changes, or raised temperature, hearing loss, or whatever. Some distinctions can be drawn. The immediate answer might be ‘the person has a virus’, ‘he has glue ear’, ‘she has had a stroke’. But still these are not fully explanatory accounts, they do not lead to an understanding of why temperature rises in the presence of a viral infection, why a stroke should bring about speech changes, and in particular why a stroke should make someone sound foreign. One needs to delve further to explain how changes associated with infection or stroke lead to the observed phenomena. Therefore clinicians or researchers seek to account for phenomena in terms of the underlying pathology, how body functions are impaired – i.e. why or how changes to body functions and structures have arisen and how these in turn can explain the observed behaviour.
Perceived health interests of college students
Published in Journal of American College Health, 2023
Craig M. Becker, Michael Stellefson, Leslie Hoglund, Ryan Martin, Hui Bian, Austin Odom
The behaviors a person chooses to engage in contribute to the health outcomes they experience. Bad or negative health is generally viewed as something to avoid because it detracts from quality and/or length of life.6 The prevention of bad health is theorized to result from avoiding associated behavioral risk factors (e.g., smoking), or the causes of bad health. The prevention of disease and infirmity is the focus of traditional health (disease) care.7 While traditional disease care may alleviate some suffering by avoiding and preventing poor health, this strategy cannot and does not actively cause good physical, mental, and social health.8 Traditional health (disease) care derives its methodology from pathology or the study of disease genesis. Pathology, the study of the origins of disease, provided the foundation for developing the biomedical model.9 Pathology reacts to a possible cause of health problems so they can be prevented and avoided. Health education programs adopting this perspective are deemed effective when behavioral risk factors are avoided and adverse health outcomes are prevented.
Clinical prognostic risk analysis and progression factor exploration of primary breast lymphoma
Published in Hematology, 2022
Jili Deng, Lan Mi, Xiaopei Wang, Jun Zhu, Chen Zhang, Yuqin Song
We retrospectively included patients diagnosed with lymphoma with breast involvement and patients who had completed at least one cycle of systemic treatment between November 2004 and October 2020 at two centers (Peking University Cancer Hospital & Institute and Peking University International Hospital). Secondary breast lymphoma was excluded, involving distant lymph nodes in non-breast drainage areas or distant organs based on the definition of PBL. Finally, 63 PB-DLBCL patients were included according to the current standard definition. The pathological diagnosis was by the World Health Organization diagnostic criteria in different periods(Version 2001, 2008,and 2016)[18]performedby the pathology department of our hospital. The staging criteria were as follows: stage I, unilateral breast involvement; stage II, unilateral breast involvement with regional lymph node involvement; and stage IV, bilateral breast involvement with or without regional lymph node involvement.
A Novel Anticancer Effect of Ephedra alata Decne in Breast Cancer Cells
Published in Nutrition and Cancer, 2022
Fairouz Sioud, Zaineb Dhouafi, Aida Lahmar, Dorra Elgueder, Leila Chekir-Ghedira
Breast cancer is the most common malignancy among women in the world with 23% of total new cancer cases, 16% of all female cancers, and 18% of total deaths related to cancer in both males and females (1, 2). Breast cancer is the most commonly diagnosed among females and the first leading cause of cancer death (3). Depending on the pathology and biology of the disease and patient characteristics, different strategies of treatment are applied to manage the disease and control the mortality, including surgery, hormone therapy, radiation therapy, cytotoxic therapy, or a combination of these treatments (4). However, the development of drug resistance to available treatments and severe side effects (5, 6) is a strong incentive for the researchers to design and develop a novel antitumor drug with more accurate targets and low toxicity.
Related Knowledge Centers
- Cardiomyopathy
- Psychopathy
- Tissue
- Infection
- Pathophysiology
- Cancer
- Pathogenesis
- Injury
- Psychology
- Physician