The Influence of Hormones on Infectious and Parasitic Disease
Istvan Berczi in Pituitary Function and Immunity, 2019
Treatment of male and female mice with testosterone protected them against pneumococcus infection, but to a lesser degree than did estrogens.61 In male mice castration reduced Coxsackie B-3 virus induced necrotic lesions and T cell mediated cytotoxicity, which would be reversed by testosterone treatment.53 The administration of androgen to ovariectomized female rats lowered their resistance to infection with larvae of Taenia taeniaeformis.55Simian virus 40 oncogenesis in adult male hamsters was accelerated by testosterone treatment.69 Purulent oophoritis and metritis occurred in female rats injected with 250 of testosterone propionate at 3 days of age. This infectious disease was caused by mycoplasma organisms.70
Syphilis
Shiv Shanker Pareek in The Pictorial Atlas of Common Genito-Urinary Medicine, 2018
The following biological factors may lead to false positives: infectious mononucleosis.hepatitis.varicella-zoster (chickenpox/shingles virus).endocarditis.mycoplasma infection.pregnancy (in rare cases).cirrhosis of the liver.tuberculosis.autoimmune disease, including systemic lupus erythematosus (SLE).
Neurocutaneous Syndromes With Interstitial Lung Disease
Lourdes R. Laraya-Cuasay, Walter T. Hughes in Interstitial Lung Diseases in Children, 2019
Since 1957, recurrent sinopulmonary infections that ultimately lead to bronchiectasis have become part of the syndrome.49 Susceptibility to recurrent infections is due to the immunologic defect. The infections may be due to bacteria, viruses, or mycoplasma. The bronchiectasis occurs often and may be diffuse. It could antedate the appearance of ataxia or telangiectasia. Pneumonia and pulmonary fibrosis are usually present.49,51 Growth retardation is a prominent feature but the levels of thyroid, adrenal and growth hormones are normal.52 Paucity of lymphoid tissue is noted. Lymphoid tissue is hypoplastic. The thymus may show atrophy, hypoplasia with absence of Hassall’s corpuscles and corticomedullary differentiation.53
Association between the presence of Mycoplasma spp. and male infertility
Published in Journal of Obstetrics and Gynaecology, 2022
Sajad Babakhani, Marziyeh Eslami, Mohammad Javad Kazemi, Mohammad Sadegh Shirsalimian, Sajad Rajabi
The pathogenesis of Mycoplasma spp. is associated with the host immunity status.Immunity status is associated with genetic andinnate characteristics, environmental factors,underlying disorders and even stress. Hence, in survey of Mycoplasma infection rate in infertile men, the immunity status should be taken into consideration (Atkinson et al. 2008). One way toeliminate this factor is to match patientand control groups regarding their quality of immunity infuture investigations by performing immunologic assays to determine the immunity status of the patients. In addition, the rate of genital infections such as those caused by Mycoplasma spp. in a community is substantially associated with sexual behavior and having multiple sexual partners (Safavifar et al. 2015). Considering the Iranian culture and since our study was conducted on married men, the discrepancies in the prevalence of Mycoplasma infection in our study and reports from other countries are reasonable.
Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment
Published in OncoImmunology, 2018
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomatà, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio, Riccardo Taulli
HMC were isolated from two patients with pleural fluid secondary to congestive heart failure, with no history of malignant disease. MPM cells were obtained after written informed consent from the Biologic Bank of Malignant Mesothelioma, S. Antonio e Biagio Hospital (Alessandria, Italy). MPM samples, identified with an Unknown Patient Number (UPN), were used within passage 6. The Ethical Committee of the S. Antonio e Biagio Hospital in Alessandria approved the study (#9/11/2011). Murine AB1 cells were purchased from Sigma Chemicals Co. (#10092305), and authenticated by microsatellite analysis using the PowerPlex kit (Promega Corporation; last authentication: January 2017). Cells were grown in Ham's F12 nutrient mixture medium (primary MPM cells) or DMEM (AB1 cells), supplemented with 10% v/v fetal bovine serum (FBS), 1% v/v penicillin-streptomycin. Cells were checked for Mycoplasma spp. contamination by PCR every three weeks; contaminated cells were discharged.
A comprehensive model for heat-induced radio-sensitisation
Published in International Journal of Hyperthermia, 2018
Sarah Catharina Brüningk, Jannat Ijaz, Ian Rivens, Simeon Nill, Gail ter Haar, Uwe Oelfke
The human cancer cell lines, HCT116 (colorectal carcinoma), and Cal27 (squamous cell carcinoma) were used to generate cell survival curves for testing the model presented. HCT116 cells were cultured in McCoy’s 5 A medium (Gibco, Paisley, UK) containing 1% antibiotics (50 U/ml each of penicillin, streptomycin B and Amphotericin B (Sigma, Poole, UK)), Cal27 cells were grown in DMEM (Gibco, Paisley, UK). All media were supplemented with 10% fetal bovine serum (PAN Biotech, Wimborne, UK). Cells were grown in T80 culture flasks in a humidified atmosphere with 5% CO2 at 37 °C and passaged twice a week using Accutase (Gibco, Paisley, UK). For experiments, cells in exponential growth phase between passages 5 and 20 were used. Regular screening for mycoplasma and bacterial contamination was performed.
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