Probiotics and Chronic Fatigue Syndrome
Martin Colin R, Derek Larkin in Probiotics in Mental Health, 2018
Sullivan et al. (2009) report a study in which they investigated 15 individuals that fulfilled the criteria set by the international researchers in the field the US Centre for Disease Control and Prevention (see Fukuda et al., 1994). The patients had high disability and fatigue severity scores. During the first two weeks of the study baseline observations without treatment were assessed, after which four weeks of probiotic product was administered, followed by a four-week follow-up period. The aim of the study was to explore Lactobacillus paracasei ssp. Paracasei F19, Lactobacillus acidophilus NCFB 1748 and Bifidobacterium lactis Bb12 on fatigue and physical activity in CFS patients. Lactobacillus paracasei ssp. is a gram-positive species of lactic acid bacteria, and is used primarily in a dairy product fermentation process and in probiotic products. Paracasei F19 is also used in the fermentation of milk product and a probiotic. Sullivan found that even though there was no discernible change in gastrointestinal microflora, patients did report neurocognitive improvements. Seemingly indicating that the administration of probiotics may have a beneficial effect on some cognitive aspects of CFS, improving subjective reports of fatigue and mood after probiotic treatment.
Probiotics, Vitamin D, and Vitamin D Receptor in Health and Disease
Marcela Albuquerque Cavalcanti de Albuquerque, Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc, Raquel Bedani in Lactic Acid Bacteria, 2020
Interestingly, VDR expression is crucial for probiotic anti-inflammatory effects. In a Salmonella infection model, Lactobacillus plantarum showed physiological and histological protection only for wild-type mice, whereas no effect was observed in VDR knockout mice (Wu et al. 2015a). Similarly, our research group found that the administration of probiotic fermented milk with Lactobacillus paracasei subsp. paracasei F19 showed a promising increase in the VDR expression at the mRNA level in wild-type mice, whereas VDR knockout mice presented an exacerbated inflammation induced by DSS when compared to wild-type mice (unpublished data).
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health
Published in Gut Microbes, 2021
Ana Nogal, Ana M. Valdes, Cristina Menni
A few studies have reported the capability of dairy products fermented or supplemented with beneficial bacteria to increase SCFA-producing bacteria. Bifidobacterium animalis subsp. lactis fermented milk product resulted in an increase of butyrate-producing bacteria and cecal SCFA in a mouse model, and an inflammation reduction.183 This statement was further validated in humans, where the same fermented milk product potentiated colonic SCFA production and increased two previously uncharacterized butyrate producers, namely MGS126 and MGS203.184 Another study reported that skimmed milk supplemented with Lactobacillus paracasei subsp. Paracasei caused in healthy young adults a significant increase in Lactobacillus, Bifidobacterium, and Roseburia and in the acetic acid and butyrate acid levels, compared with the control (only skimmed milk).185
Immunological effects of AFM1 in experimental subchronic dosing in mice prevented by lactic acid bacteria
Published in Immunopharmacology and Immunotoxicology, 2020
Jalila Ben Salah-Abbès, Hela Belgacem, Khawla Ezdini, Marwa Mannai, Ridha Oueslati, Samir Abbès
Thirty colonies isolated from artisanal butter samples for potential AFM1 degrading microbial strains were screened (data not shown). Among them, one strain from sample butter BEJ01, which was able to degrade AFM1 most, was isolated and identified. It was Gram-positive and catalase negative. The results related to the physiological characteristics of the selected bacteria are shown in Table 1. Also, it was arginine negative and has the ability to hydrolyze esculin. The identification by API 50CHL kit consisted most probably of Lactobacillus paracasei. The 16S rDNA sequencing confirmed that the isolate belonged to Lactobacillus paracasei species. The 16S rDNA sequencing showed 99% homology with Lactobacillus paracasei. Moreover, the isolate was able to produce the d-lactic acid isomer.
The clinical evidence for postbiotics as microbial therapeutics
Published in Gut Microbes, 2022
Alexis Mosca, Ana Teresa Abreu Y Abreu, Kok Ann Gwee, Gianluca Ianiro, Jan Tack, Thi Viet Ha Nguyen, Colin Hill
Acute diarrhea is a significant cause of childhood morbidity and mortality in developing countries31 and rotavirus is the most common pathogen causing 29% to 45% of severe diarrhea cases.32 Acute gastroenteritis has been found to cause large-scale alterations of the intestinal microbiome.33 Enteric bacterial infections markedly reduce the intestinal microbiome richness and diversity which can last up to 14 weeks post-infection.34 Similar changes are observed with viral diarrhea.35 Microbiome alterations are more significant in children with a “failure to thrive” and these children also take longer to recover from diarrheal illness.36 Postbiotics may help to mitigate these alterations and preserve a balanced microbiome during and after diarrheal illnesses. Although live Lactobacillus has been shown to be effective against viral diarrhea,37,38 studies have also demonstrated that heat-treated Lactobacillus LB can promote faster recovery, reduce morbidity and reduce hospitalization duration.39–41 Furthermore, well-controlled studies have shown that heat-treated Lactobacillus paracasei helps prevent diarrhea by significantly reducing the number of diarrhea episodes compared with a placebo.42,43
Related Knowledge Centers
- Commensalism
- Fermentation
- Gastrointestinal Tract
- Lactic Acid Bacteria
- Morphology
- Phenotype
- Probiotic
- Bacillus
- Genotype
- Gram-Positive Bacteria