Corticosteroids
Sarah H. Wakelin, Howard I. Maibach, Clive B. Archer in Handbook of Systemic Drug Treatment in Dermatology, 2015
Corticosteroids have been widely used in dermatology since the 1950s. Some of the diseases for which they are commonly prescribed are as follows: Dermatitis: acute contact dermatitis, atopic dermatitis, chronic actinic dermatitis, exfoliative dermatitis due to drugs.Connective tissue diseases: lupus erythematosus (all types), dermatomyositis, mixed connective tissue disease, relapsing polychondritis, eosinophilic fasciitis.Immunobullous diseases: pemphigus (all types), bullous pemphigoid, cicatricial pemphigoid, pemphigoid gestationis, linear IgA disease, epidermolysis bullosa aquisita.Vasculitis: hypersensitivity vasculitis, polyarteritis nodosa, Wegener’s granulomatosis.Neutrophilic dermatoses: Sweet’s syndrome, pyoderma gangrenosum, Behçet’s disease.Other dermatoses: lichen planus, sarcoidosis, acute severe urticaria, angioedema, Stevens–Johnson syndrome (but not toxic epidermal necrolysis), large haemangiomas.
Animal Models Of Connective Tissue Diseases
Marcos Rojkind in Connective Tissue in Health and Disease, 2017
Several previous reports have discussed the comparative aspects of connective tissue diseases.6-8 It is the intent of this chapter to present both established and emerging animal models of connective tissue diseases. This chapter has been structured to include both inherited and induced disorders of connective tissue. Major headings and subheadings include disease processes at different levels of biological organization, i.e., collagen diseases vs. arteriosclerosis.
Fibromyalgia
Michael S. Margoles, Richard Weiner in Chronic PAIN, 2019
The symptoms of malaise, fatigue, myalgia, and arthralgia accompany many connective tissue diseases. Patients with early rheumatoid arthritis may have a positive test for rheumatoid factor despite evanescent physical findings of synovitis or other evidence of articular inflammation. The response of the patient with rheumatoid arthritis to large doses of salicylates is greater than that of the patient with FS, although the latter may obtain some relief.
Impact of double positive for anti-centromere and anti-SS-a/Ro antibodies on clinicopathological characteristics of primary Sjögren’s syndrome: a retrospective cohort study
Published in Modern Rheumatology, 2018
Yasunori Suzuki, Hiroshi Fujii, Hideki Nomura, Ichiro Mizushima, Kazunori Yamada, Masakazu Yamagishi, Mitsuhiro Kawano
We reviewed 343 patients with labial salivary gland biopsy from 1998 to 2015 referring to their medical records. We excluded 151 patients who did not meet the classification criteria of SS, and 53 secondary SS patients with other connective tissue disease, including 17 with systemic sclerosis (Figure 1). One hundred and thirty nine patients met the Japanese Ministry of Health revised criteria [1] and/or American College of Rheumatology criteria [3] with cases with more than 1 focus score selected for this study. All the patients were also evaluated using the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria [19]. Systemic sclerosis was diagnosed according to the 1980 American Rheumatology Association criteria [20] and diffuse or limited scleroderma by LeRoy’s criteria [21]. Other connective tissue diseases were diagnosed according to the respective established criteria.
Identification and management of connective tissue disease-associated interstitial lung disease: evidence-based Japanese consensus statements
Published in Expert Review of Respiratory Medicine, 2023
Masataka Kuwana, Masashi Bando, Yutaka Kawahito, Shinji Sato, Takafumi Suda, Yasuhiro Kondoh
Connective tissue diseases (CTDs) comprise a large group of systemic disorders characterized by dysfunction of multiple organ systems due to inflammation and fibrosis. In patients with CTDs, respiratory complications are frequent, with interstitial lung disease (ILD) being the most common [1]. ILD occurs in patients with various CTDs, including rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM), Sjögren’s syndrome, systemic sclerosis (SSc), systemic lupus erythematosus, and mixed connective tissue disease (MCTD) [1,2]. ILD is the leading cause of premature mortality in RA [3,4], PM/DM [5,6], Sjögren’s syndrome, SSc [7,8], and MCTD [9]. The onset, progression speed, treatment response, and prognosis of CTD-ILDs are highly variable among patients; some develop rapidly or slowly progressive course, leading to mortality, and others have stable ILD with no clinically meaningful progression during the course of the disease. Furthermore, respiratory complications may also arise from infection and drug-induced lung injury, which often make diagnosis, evaluation, and treatment of ILD difficult. Thus, for both pulmonologists and rheumatologists, personalized management is essential for improving outcomes in patients with CTD-ILD.
Presence of anti-TIF-1γ, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study
Published in Immunopharmacology and Immunotoxicology, 2021
Mónica Vázquez-Del Mercado, Erika Aurora Martínez-García, Adrián Daneri-Navarro, Eduardo Gómez-Bañuelos, Beatriz Teresita Martín-Márquez, Oscar Pizano-Martínez, Eduardo A. Wilson-Manríquez, Esther Guadalupe Corona-Sánchez, Efrain Chavarria-Avila, Flavio Sandoval-García, Minoru Satoh
The clinical stage, hormonal stage (perimenopausal, menopausal and postmenopausal) [8], histopathology diagnosis (including cancer subtype) and immunohistochemistry (IHC) for estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (Her2/Neu) and triple negative status [9–11] were obtained from the clinical charts. Histopathology of breast cancer was classified by two experts and in case of major discordance, a third expert evaluated the biopsy. The classification included the following categories: ductal invasive, lobular invasive, medullar invasive, intraductal, mixed (ductal-lobular) invasive, papillar adenocarcinoma, ductal microinvasive, mucinous invasive, ductal in situ and unknown. Clinical evidence for a connective tissue disease was systematically obtained by retrospective chart review.