Skin infections
Ronald Marks, Richard Motley in Common Skin Diseases, 2019
Both these lesions result from S. aureus infection of hair follicles. They are much less common now than 30 or even 20 years ago, presumably because of improved levels of hygiene. Nonetheless, there are still families and individuals who are troubled by recurrent boils. In many instances, the pathogenic Staphylococcus colonizes the external nares, the perineum or other body sites and is difficult to dislodge. The lesions are localized, red, tender and painful swellings; carbuncles may be quite large, perhaps 3–4 cm in diameter, and represent the infection of several follicles.
Inflammatory, Hypersensitivity and Immune Lung Diseases, including Parasitic Diseases.
Fred W Wright in Radiology of the Chest and Related Conditions, 2022
The disease usually starts with a blister at the site of the flea-bite; this may then become a 'black carbuncle'. Fresh carbuncles and spots may appear. Nodal disease then follows in the axillae or groins ('bubonicplague'), later becoming septicaemic with pneumonia (and occasionally also leading to plague meningitis). When pneumonia occurs, with bacilli in the sputum ('pneumonic plague') air-borne transmission may occur from man to man.
Skin and Soft Tissue Infections
Thomas T. Yoshikawa, Shobita Rajagopalan in Antibiotic Therapy for Geriatric Patients, 2005
Carbuncles involve several adjacent hair follicles, creating an inflammatory mass with pus discharging from several follicular orifices. Carbuncles commonly occur on the face, neck, upper extremities, and buttocks. Compared with furuncles, carbuncles are frequently accompanied by constitutional symptoms (26). Both furuncles and carbuncles drain to the skin surface along the hair follicles. Carbuncles are often associated with diabetes mellitus. The most common etiologic agent is
A systematic review on efficacy, safety, and treatment-durability of low-dose rituximab for the treatment of Pemphigus: special focus on COVID-19 pandemic concerns
Published in Immunopharmacology and Immunotoxicology, 2021
Soheil Tavakolpour, Zeinab Aryanian, Farnoosh Seirafianpour, Milad Dodangeh, Ifa Etesami, Maryam Daneshpazhooh, Kamran Balighi, Hamidreza Mahmoudi, Azadeh Goodarzi
In the study that three weekly consecutive doses of 375 mg/m2 of RTX and one similar dose repeated after 3 months of the third dose was used [24], the most of Side effects occurred during the first infusions; moderate fever and chills (6/24), hypotension (2/24), and hypertension (2/24) which were controlled by either stopping or decreasing the rate of infusion, was seen. In second infusions, patients experienced no infusion reactions. 8% of patients (2/24) developed herpes zoster and the next infusion was deferred till the lesions healed after treatment with an antiviral drug. One of them also developed an extensive tinea corporis. And, a diabetic patient developed a carbuncle that was treated with antibiotics, after that he involved to pulmonary embolism (a month following the first three infusions) and was treated successfully in an ICU setting. One patient developed recurrent diarrhea with weight loss of 10 kg within a month and was diagnosed with Isospora diarrhea that was treated successfully with cotrimoxazole.
Profiling and identification of chlorogenic acid metabolites in rats by ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer
Published in Xenobiotica, 2018
Fei Wang, Zhanpeng Shang, Lulu Xu, Zhibin Wang, Wenjing Zhao, XiaoDan Mei, Jianqiu Lu, Jia Yu Zhang
Traditional Chinese medicine has been extensively used to prevent and cure many diseases that have inflicted humans for more than 4000 years (Dasgupta et al., 2002). Flos Lonicera Japonica (Jinyinhua in Chinese), the dried flower bud of Lonicera japonica, possesses many biological properties, including hepatoprotective, cytoprotective, antimicrobial, antioxidative, antiviral and anti-inflammatory activities. It is commonly used for the treatment of various diseases, including carbuncles, furuncles, swelling, infections and sores caused by exopathogenic wind-heat or epidemic febrile diseases at the early stage (Lee et al., 2010; Niggeweg et al., 2004). Meanwhile, it was also used in indigenous beverages in China and Korea (Wang et al., 2008).
Rituximab treatment for refractory nephrotic syndrome in adults: a multicenter retrospective study
Published in Renal Failure, 2023
Xiaoyan Ma, Lu Fang, Lili Sheng, Xun Zhou, Shoujun Bai, Xiujuan Zang, Yakun Wang, Mengke Li, Zexin Lv, Qin Zhong, Xinyu Yang, Yishu Wang, Yan Hu, Danying Yan, Yingfeng Shi, Hui Chen, Jinqing Li, Min Tao, Shougang Zhuang, Yi Wang, Na Liu
RTX was well tolerated in almost all patients. With methylprednisolone and cetirizine administration before infusion, no severe adverse event was observed during infusion in all patients. In this study, no patients treated with RTX developed agranulocytosis, cytopenia, infusion reactions, hypertension, and gastrointestinal pain. One patient occurred nausea and vomiting, one patient suffered from carbuncle, four patients experienced slightly elevated ALT/AST, two patients experienced urinary tract infection, two patients developed pneumonia, five patients occurred rash, and one patient developed influenza-like symptoms as demonstrated in Table 3. All patients were treated appropriately.
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