Experimental Stomatology
Samuel Dreizen, Barnet M. Levy in Handbook of Experimental Stomatology, 2020
Ten of the women developed symptoms similar to pellagra sine pellagra between the 94th and 130th day. There was maceration of the angles of the mouth, reddening of the lips along the line of closure, and thinning and denudation of the mucosa. The word “cheilosis” was coined to describe the morbid condition of the lips. In addition to the lip lesions, the subjects developed a scaly, greasy desquamation in the nasolabial folds, on the alae nasi, in the vestibule of the nose, and — in a few instances — on the ears and eyelids. In all ten women with cheilosis, the lesions did not respond to the administration of nicotinic acid but did disappear following riboflavin therapy. They recurred after riboflavin was discontinued and responded again when therapy was reinstituted. Of the eight women who did not develop cheilosis by the 139th day, four were given a daily preventive dose of riboflavin and four were not. Of the latter, two developed cheilosis on the 191st and 203rd day, and one had a slight maceration at the angles of the mouth on the 200th day.
Nutritional Disorders/Alternative Medicine
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss in Understanding Medical Terms, 2020
Toxicity of the fat-soluble vitamins may be caused by diminished urinary excretion of normal body stores, as well as ingestion of excess amounts. Acute vitamin A toxicity can occur after a single large dose. The chronic toxicity of hypervitamimosis A results in pruritus (itching), dry scaly skin, changes in nail and hair texture, bone pain, increased cerebrospinal fluid pressure, and hypercalcemia. Prolonged use of vitamin A, even in therapeutic doses, can cause fatigue, nausea, vomiting, dizziness, irritability, cheilosis (inflammation at the corners of the mouth), and generalized skin desquamation (shedding).
Assessment – Nutrition-Focused Physical Exam to Detect Micronutrient Deficiencies
Jennifer Doley, Mary J. Marian in Adult Malnutrition, 2023
Common physical signs of micronutrient deficiencies exhibited on the lips include cheilosis, or angular stomatitis (Figure 7.4). Cheilosis is an inflammation of one or both corners of the mouth, and appears as fissures and sores on the lips, which may split and bleed. Potential micronutrient deficiencies associated with this condition include vitamins B2, B3 and B6, as well as iron. Potential non-nutrient causes include dehydration, chapping from harsh climates, and herpes and/or other infectious diseases.4,8
Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience
Published in Journal of Dermatological Treatment, 2020
Roberta Piccinno, Simona Tavecchio, Valentina Benzecry
Since the lips dominate the appearance of the lower face, frequently patients are diagnosed of non-melanoma skin cancer (NMSC) of the lip at an early stage of the disease, without lymph node involvement. In terms of persistence and recurrence, the lip is considered a high-risk anatomical area for both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Lip SCC accounts for 25–30% of all oral cancers, often preceded by actinic cheilosis, associated to risk factors such as male sex, older age, fair skin, and sun exposure, with a trend to decline in incidence (1). BCC of the lip is more common in female sex and more frequently observed on upper lip, but data are not homogeneous. On the whole SCC is nearly four times as common as BCC in lower lip, that is the opposite ratio respect to all anatomical sites, with a ratio of BCC to SCC of 4:1 (2).
Chemotherapy-Induced Oral Complications and Prophylaxis Strategies
Published in Cancer Investigation, 2023
Aleksandra Śledzińska, Paulina Śledzińska, Marek Bebyn, Oskar Komisarek
Many patients with oropharyngeal candidiasis are asymptomatic. However, when symptoms do occur, patients typically report a cottony sensation in the mouth, a loss of taste, and, in some cases, pain during eating and swallowing. During a physical examination, there are two major forms of oropharyngeal candidiasis: the pseudomembranous form is the most prevalent. It manifests as white plaques on the buccal mucosa, palate, tongue, and oropharynx. The atrophic type, often known as denture stomatitis, affects the elderly who wear upper dentures. It is found under upper dentures and is characterized by erythema without plaques (89). Angular cheilitis, commonly known as angular stomatitis or perlèche, is characterized by bright red erythematous along the commissures of the mouth (90). Angular cheilitis manifests as bilateral, bright red erythematous fissures around the angles of the mouth (Figure 3) (91). Chronic hyperplastic candidiasis is rarely observed.
A 30-year follow-up study of patients with Melkersson–Rosenthal syndrome shows an association to inflammatory bowel disease
Published in Annals of Medicine, 2019
Anu Haaramo, Kaija-Leena Kolho, Anne Pitkäranta, Mervi Kanerva
Over half of the patients with MRS reported some oral symptoms during their follow-up. A similar proportion of adult patients with paediatric-onset CD also reported oral symptoms [17]. In patients with MRS, aphthous ulceration and blistering were the most common oral symptoms. One-quarter of the patients reported suffering from angular cheilitis. In patients with OFG, angular cheilitis was found in half of the patients, and in patients with paediatric CD, it was the most frequently seen oral lesion, present in 15% of the patients [6,17]. However, angular cheilitis is not specific to CD or OFG, and it is also observed in otherwise healthy individuals. Other oral symptoms in patients with MRS were sporadic. Some of the patients had noticed that oral symptoms coincided with facial oedema, while others did not. Interestingly, over half of the patients who reported oral lesions had noticed that certain food substances caused or exacerbated the symptoms, and therefore avoided those substances in their diet. None of the patients reported food allergies that were formally diagnosed with a food challenge.