Development of palliative medicine in the United Kingdom and Ireland
Eduardo Bruera, Irene Higginson, Charles F von Gunten, Tatsuya Morita in Textbook of Palliative Medicine and Supportive Care, 2015
The clinical signs resemble aphthous stomatitis, and it may cause treatment delay or interruption due to pain. The lesions appear within few days after administration of the drug and resolve in approximately 1 week. They are characterized by distinct, ovoid, superficial, well-demarcated ulcerations with a central gray area surrounded by an erythematous halo and are localized on the movable oral/oropharyngeal mucosa while not presenting on the keratinized mucosa of the hard palate, gingiva, or dorsum of the tongue. The pathogenesis is assumed to be similar to aphthous stomatitis. Patients who develop these lesions may be more likely to have nonspecific cutaneous rashes and acneiform dermatitis but not gastrointestinal adverse effects. Â 17,18 See "Basic Oral Care" section and Figure 117.3 for management strategies. Â 19
Colchicine
Sarah H. Wakelin, Howard I. Maibach, Clive B. Archer in Handbook of Systemic Drug Treatment in Dermatology, 2015
Colchicine is licensed only for use in gout and familial Mediterranean fever. Dermatological uses, mainly supported by uncontrolled studies, include the following: Recurrent aphthous stomatitis.Behçet’s disease.Neutrophilic dermatoses including Sweet’s disease and pyoderma gangrenosum.Dermatitis herpetiformis (in patients intolerant of dapsone), epidermolysis bullosa acquisita and linear IgA disease.Leukocytoclastic vasculitis, especially urticarial vasculitis.Scleroderma.Cutaneous amyloidosis. Erythema nodosum and genital lesions in women have been shown to respond but there is no clear effect on oral ulceration in Behçet’s disease. Except for some forms of mucocutaneous Behçet’s disease, where colchicine has been shown to be effective in double blind studies, it is not a first-line agent for any of the above conditions.
Adverse drug reactions on the skin
Robert A. Norman in Geriatric Dermatology, 2020
Aphthous stomatitis — also known as canker sores — is a common disease of the oral mucous membranes. Arising as tiny, discrete or grouped, papules or vesicles, these painful lesions develop into small (2–5 mm in diameter), round, shallow ulcerations having a grayish, yellow base surrounded by a thin red border. Located predominantly over the labial and buccal mucosae, these aphthae heal without scarring in 10 to 14 days. Recurrences are common.
Thyroid gland involvement in secondary syphilis: a case report
Published in Acta Clinica Belgica, 2022
Thomas Strypens, Gudrun Alliet, Greet Roef, Linsey Winne
Physical examination at the emergency department showed a pulse rate of 135 beats per minute, a body temperature of 37.6°C, a blood pressure of 126/44 mmHg, a saturation of 100%, and a respiratory rate of 14/min. Heart auscultation was normal without carotid murmurs. Limited end-expiratory wheezing was heard during lung auscultation. The examination of the oral cavity showed aphthous stomatitis. Examination of the neck showed a non-tender, erythematous swelling, approximately 4 cm in diameter at the midline of the neck with local inflammation. Palpation was very painful. There was a palpable, firm, approximately 2 cm large, painful cervical lymphadenopathy located in the third neck region. There were several sharply defined erythematosquamous plaques on the trunk and extremities. Some plaques in the elbow region and on the trunk showed signs of necrosis.
N-acetylcysteine versus chlorhexidine in treatment of aphthous ulcers: a preliminary clinical trial
Published in Journal of Dermatological Treatment, 2021
Esam Halboub, Baleegh Alkadasi, Mohammed Alakhali, Ali AlKhairat, Huda Mdabesh, Somaya Alkahsah, Saleem Abdulrab
Aphthous ulcers, or recurrent aphthous stomatitis (RAS), is a benign oral ulcerative disease and the most common ulcerative disorder of the oral mucosa. The point prevalence is 1.5%, but the annual and lifelong prevalence rates in general population are 20% and 40%, respectively, with higher figures reported for specific population segments (1–3). A RAS episode is characterized by one or more round shallow ulcers with a well-demarcated erythematous margin and a yellowish to grayish pseudomembranous central area. The associated pain ranges from very mild to very severe (4). On the basis of their size and number, RAS can be classified as minor, major, and herpetiform. Minor recurrent aphthous stomatitis (usually less than 10 mm) is the most common form accounting for 80% RAS patients (2).
Investigation of dissolved cellulose in development of buccal discs for oromucosal drug delivery
Published in Pharmaceutical Development and Technology, 2018
Emrah Yildir, Erica Sjöholm, Maren Preis, Poonam Trivedi, Jani Trygg, Pedro Fardim, Niklas Sandler
Inflammatory, atrophic, and ulcerative conditions such as oral lichen planus, aphthous stomatitis, erythema multiforme, and Behcet’s syndrome appear at the oral cavity. Among these conditions, recurrent aphthous stomatitis (RAS) is one of the most common painful oral mucosal conditions seen in the oromucosal area (Preeti et al. 2011; Belenguer-Guallar et al. 2014). RAS can occur as single or multiple shallow painful ulcers on buccal, labial, and tongue mucosa and can be caused by microbial, nutritional, immunological, genetic factors, and psychosocial stress (Akintoye and Greenberg 2014). Currently, many different types of drugs have been tried for the treatment topically and systematically. Some of the anti-inflammatory agents used in topical therapies are glucocorticoids (triamcinolone acetonide, fluocinonide, etc.), antimicrobials (chlorhexidine gluconate), and anti-TNF-alpha agents (pentoxifylline, thalidomide, colchicine, etc.) (Ship 1996; Scully and Porter 2008). Among these substances, systemically or topically applied corticosteroids such as triamcinolone acetonide have been studied to reduce and heal the ulcers sustainably (Zegarelli et al. 1960; Browne et al. 1968; Miles et al. 1993; Ahn et al. 2002; Ghalayani et al. 2017). In addition to symptom alleviating substances, drug compounds with local anesthetic effects such as articaine, lidocaine hydrochloride or benzydamine hydrochloride have been studied and used to relieve oral mucosal pains (Ship et al. 1960; Epstein et al. 2001; Malamed et al. 2001; Wolf and Otto 2015).
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