Anti-HSV and Cytotoxicity Properties of Three Different Nanoparticles Derived from Indian Medicinal Plants
P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas in Advanced Studies in Experimental and Clinical Medicine, 2021
Synthesis of gold nanoparticles was done as described previously by Tiwari (2011). Briefly, lyophilized powder of Plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with 0.002 M of chlororauric acid (SRL Cat. No) (HAuCl4) in dark conditions with a preincubation at 90°C. After incubation the color of the solution were turned its color to ruby pink (Figure 13.2) indicates the gold nanoparticle formation. According to Klaus (2001) synthesis of silver Nanoparticles was done. Briefly, lyophilized powder of plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with 20 ml of 10−3 M AgNO3 (SRL Cat. No: Cat. No for (HAuCl4)-12023, Cat. No for (AgNO3) – 94118) (99.99%) aqueous solution and kept at room temperature. After 1 hour the color of the solution were changed from colorless to honey brown (Figure 13.2) indicating the formation of silver nanoparticles and this is confirmed by UV-visible spectroscopy and other methods. Synthesis of bimetallic nanoparticles (Silver-Gold) were done according to the Pal et al. Briefly, lyophilized powder of plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with equal amount of 10−3 M AgNO3 and 0.002 M of chlororauric acid and incubated at room temperature. After incubation the color of the solution were turned its color in the combination of ruby pink and honey comb color (Figure 13.2).
In Vivo Suppression of Solid Ehrlich Cancer via Ag and Co/Ag Mediated PTT
Anne George, K. S. Joshy, Mathew Sebastian, Oluwatobi Samuel Oluwafemi, Sabu Thomas in Holistic Approaches to Infectious Diseases, 2017
Silver nanoparticles are among the noble metallic nanomaterials that have received considerable attention due to their attractive physicochemical properties. The surface plasmon resonance and the large effective scattering cross-section of individual nanoparticles make them ideal candidates for biomedical applications (Liau, et al., 1997). Nowadays many studies focused on nontoxic silver nanoparticles synthesis for biological application (Schneidewind et al., 2012; Haberl et al., 2013). On the other hand, silver nano-shells of 40–50 nm outer diameter and 20–30 nm inner diameter using cobalt nanoparticles as sacrificial templates were also synthesized. As a result, the thermal reaction deriving force resulted from a large reduction potential gap between the Ag+/Ag and the Co+2/Co redox couples, which leads to the consumption of Co cores and the formation of a hollow cavity of Ag nano-shells. The UV spectrum of such nanostructure exhibits a distinct difference from that of solid nanoparticles, making it a good candidate for application in photo-thermal materials (Chen and Lian Gao, 2006).
Ecotoxicology of Nanoparticles
Suresh C. Pillai, Yvonne Lang in Toxicity of Nanomaterials, 2019
Predictive models evaluating Ag concentrations in geographical regions have emerged, possibly in response to the specificities pertinent to the water chemistry in different water courses. A mass flow analysis was carried out by Blaser et al. (2008), who used a model of the Rhine River based on a projected population for the EU25 of 469 million and incorporating the aquatic eco-load of anti-microbial plastics and textiles, which they state contributes to 15% of the silver load in rivers. The environmental fate of silver nanoparticles was also studied by Blaser et al. (2008), who reported that the majority of soluble silver in natural freshwater is expected to be in the form of silver sulphide and that free silver ions are only a potential problem if silver concentrations exceed the ambient sulphide concentrations.
Synergistic effect of silver nanoparticles and polymyxin B against biofilm produced by Pseudomonas aeruginosa isolates of pus samples in vitro
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Muhammad Salman, Rizwana Rizwana, Hayat Khan, Iqbal Munir, Muhammad Hamayun, Aquib Iqbal, Abdul Rehman, Khalid Amin, Ghayour Ahmed, Majid Khan, Ajmal Khan, Faiz Ul Amin
Drug discovery programs, in order to develop new safer and more efficacious new Polymyxin B derivatives to overcome these problems, have got miniature success [20]. Another option is the usage of Polymyxin B in amalgamation with other antimicrobial agents including nanoparticles (NPs). Use of NPs-antibiotic combinations in order to eliminate and prevent bacterial biofilms formed by multidrug-resistant bacteria show great promise [22,23]. Silver nanoparticles are extraordinarily efficient at absorbing, optical, electrical and thermal properties. These are reported as antibacterial agents to treat septic burns and wounds [24]. Silver NP is one of the most attractive inorganic materials due to its wonderful applications in catalysis, biomolecular detection, photography, diagnostics, biosensor and particularly antimicrobial activities. Furthermore, it is environmentally non-threatening in nature [25]. The size of NPs plays a key role as greater prevention rate can be achieved by a smaller size of NPs and high surface to mass ratio. Some studies showed that shape is also a remarkable factor, e.g. rod-shaped NPs have greater destruction effect as compared to spherical shape NPs against biofilms [26]. Biofilm integrity is interfered by NPs through interacting with EPSs [27].
Green Fabrication of silver nanoparticles by leaf extract of Byttneria Herbacea Roxb and their promising therapeutic applications and its interesting insightful observations in oral cancer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2023
Gunashekar Kalvakunta Subramanyam, Susmila Aparna Gaddam, Venkata Subbaiah Kotakadi, Hema Gunti, Sashikiran Palithya, Josthna Penchalaneni, Varadarajulu Naidu Challagundla
The present era of research is mainly focussed on Nano-materials and Nanostructures derived from physical, chemical and biological sources that play an important role in nanotechnology for their promising industrial, pharmaceutical and biomedical applications. Over the past few decades, the metal nanoparticles fabricated from different noble metals exhibited distinct biological, physical and chemical properties. Among these metal nanoparticles silver nanoparticles (AgNPs) became the most commonly investigated, interesting and challenging nano-materials suitable for various potential therapeutic applications [1–2]. At present, the nano-sized particles less than 100 nm in size are gaining attention abundantly due to their new applications in various industries like medical, health care, food and pharmaceutics. Presently, in the past two decades, it clearly revealed that silver nanoparticles attained great interest due to their shape, size and size distribution which plays an important role in optical, electromagnetic, electrical, thermal, catalytic and biological properties [3–6]. Currently, widespread research on silver nanoparticles reveals excellent anticancer and antimicrobial properties [7–10].
Antioxidant, antimicrobial and cytotoxic potential of silver nanoparticles synthesized using flavonoid rich alcoholic leaves extract of Reinwardtia indica
Published in Drug and Chemical Toxicology, 2019
Prabhat Upadhyay, Sunil K. Mishra, Suresh Purohit, G. P. Dubey, Brijesh Singh Chauhan, S. Srikrishna
Nanoparticles (NPs), which are defined as particles having at least one dimension of 100 nm or less, are used to produce novel materials with unique physicochemical properties. Their small size high surface area per unit mass, chemical composition and surface property effects may be important factors in NP-induced toxicity, and nonspecific oxidative damage is one of the greatest concerns. To overcome the complication of toxicity in the synthesis and biological applications, plants or plant extracts have been established to have a leading role in the AgNPs biosynthesis process (Khan et al. 2017). Silver nanoparticles can be synthesized using a variety of chemicals and physical methods, involving chemical reduction, photochemical reduction, electrochemical reduction and heat vaporization. These processes involve several toxic chemicals as reducing agents. Because of using noble metal nanoparticles in areas of human contact, there is an emergent need to develop eco-friendly biosynthesis processes that hinder the use of toxic chemicals. The use of silver nanoparticles both as an antimicrobial agent and as a potential drug carrier in the treatment of cancer has recently gained considerable attention (Iravani et al. 2014).
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