Cancer pain syndromes
Nigel Sykes, Michael I Bennett, Chun-Su Yuan in Clinical Pain Management, 2008
Meningeal carcinomatosis occurs as a result of metastatic spread into the cerebrospinal fluid. Numerous metastatic seedlings develop on the meninges of both the brain and the spinal cord. There may also be concomitant invasion of the central nervous system (CNS). In one survey, meningeal infiltration by cancer occurred in about 10 percent of patients with disseminated cancer.17 In another survey, 90 percent of cases related to: breast cancer (>50 percent);lung cancer (>25 percent);melanoma (12 percent).18
Neurology
Fazal-I-Akbar Danish in Essential Lists of Differential Diagnoses for MRCP with diagnostic hints, 2017
Low CSF glucose (with normal plasma glucose):1 Meningeal irritation: a Meningitis (bacterial/tuberculous).b Meningeal carcinomatosis.c Subarachnoid haemorrhage.
Headache associated with nonvascuiar intracranial disorders
Stephen D. Silberstein, Richard B. Upton, Peter J. Goadsby in Headache in Clinical Practice, 2018
The justification for subjecting patients to meningeal biopsy no longer exists. The information on biopsy dates back to the initial observations of meningeal enhancement on MRI, when clinicians were not confident about the association of pachymeningeal enhancement and CSF leaks or intracranial hypotension.18,21,76,77 Then, understandably, patients were vigorously investigated for various types of meningeal disease, particularly meningeal inflammation, infection, and meningeal carcinomatosis.
Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss
Published in International Journal of Audiology, 2020
Meningeal carcinomatosis is defined as the diffuse infiltration of the leptomeninges and subarachnoid space by malignant cells metastasising from neoplasm such as lung cancer, breast cancer, melanoma, and so on (Olson, Chernik, and Posner 1974). It generally elicits multiple neurologic deficits from more than one anatomic site, manifesting as progressive bilateral hearing loss if both ears are affected (Civantos, Choi, and Applebaum 1992).
Research progress in strategies to improve the efficacy and safety of doxorubicin for cancer chemotherapy
Published in Expert Review of Anticancer Therapy, 2021
Muhammad Sohail, Zheng Sun, Yanli Li, Xuejing Gu, Hui Xu
Human brain capillary endothelial cells were used to assess the efficiency (uptake and affinity) of 2B3-101 in vitro [81]. The uptake of the 2B3-101 system is dependent on concentration, temperature, and time. The existence of glutathione increased the 2B3-101 system’s efficacy, increasing DOX delivery efficacy. Meningeal carcinomatosis is another condition for which the 2B3-101 system is being investigated. (NCT01818713) [83].
Related Knowledge Centers
- Central Nervous System
- Cerebrospinal Fluid
- Lung Cancer
- Melanoma
- Meninges
- Posterior Cranial Fossa
- Pia Mater
- Medulloblastoma
- Breast Cancer
- Complication