The Present Developmental State of Cancer Multistem Therapy (CMT): Selective Occlusion of Cancer Tissue Capillaries by Combining Hyperglycemia with Two-Stage Regional or Local Hyperthermia Using the CMT Selectotherm Technique
Leopold J. Anghileri, Jacques Robert in Hyperthermia in Cancer Treatment, 2019
In the scope of the clinical CMT trials, which have been carried out in close cooperation with the Radiologische Klinik (headed by Prof. Dr. R. Barke) of the Medizinische Akademie Dresden, it was demonstrated for the first time in late 1979 that human tumors can also be eradicated by selective destruction of their capillary network. For example, a clear cell sarcoma weighing about 2 kg and located above the knee disappeared 3 weeks after CMT treatment, as can be seen from the arteriographies in Figure 8. This result was presented first in the Festschrift on the occasion of the 25th anniversary of our institute.44 In the 4 years that have passed, neither a relapse nor metastases have occurred. The female patient has been without symptoms since 1979 and manages her household. Figure 9 demonstrates the regression of a lymph node metastasis in the same patient. Another pair of roentgenograms clearly showing the destruction of smaller tumor vessels is given in Figure 10. The program of basic CMT therapy employed in principle on these cases is presented and explained in Figure 11.
Penile Cancer
Dongyou Liu in Tumors and Cancers, 2017
If FNA is negative, the National Comprehensive Cancer Network (NCCN)© recommends excisional biopsy in order to address a possible sampling error, and if the FNA is positive, full lymph node dissection is recommended. CT scan is the standard method for staging penile tumors presenting as >T1, and abdominal and chest CT scan is recommended for poorly differentiated tumors or those with >N2 stage. MRI and FDG-PET can be used to detect lymph node metastasis as well, but pelvic CT scan remains the standard modality for staging. In patients without palpable inguinal lymphadenopathy, the NCCN protocol suggests surveillance for low-risk (<T1G1) patients and sentinel lymph node biopsy in high-risk (>T1G1) patients [7]. Dynamic sentinel node biopsy (DSNB) offers staging in patients with non-palpable inguinal lymph nodes who still exhibit poor prognostic factors within the primary tumor. DSNB is a low-morbidity surgical staging technique that localizes the sentinel node via visual or gamma emission. This process consists of injecting blue dye or technetium-labeled colloid next to a lesion and allowing the lymphatic system to transport the tracer to a specific node.
Sensing of Magnetic Nanoparticles for Sentinel Lymph Nodes Biopsy
Shoogo Ueno in Bioimaging, 2020
If the developed method of combining sentinel lymph node biopsy using magnetic sensors and rapid intraoperative diagnosis is put to practical use, the accuracy of metastasis diagnosis will improve in small- and medium-sized medical institutions that can handle many cases. If intraoperative immunostaining can be realized, it can likely reduce the risk of oversight in conventional rapid pathological diagnosis, and the recurrence rate can be reduced. Moreover, promoting the expansion of facilities where operations can be performed will enable early treatment, improve the QoL of patients, and help reduce the physical, economical, and mental burdens. This method is not limited to breast cancer and it has the potential to be applied to a wide range of cancer cases. Furthermore, theoretically, it is not limited to lymph node metastasis, but can also be applied to lung metastasis and bone metastasis, and it is expected that it will be incorporated in procedures for these cases as well. Socially, it can be promising for reducing medical expenses, extending the survival period of patients, and increasing productive labor time.
A Nomogram for Predicting Lymph Nodal Metastases in Patients with Appendiceal Cancers: An Analysis of SEER Database
Published in Journal of Investigative Surgery, 2021
Dan Wang, Chongshun Liu, Tingyu Yan, Chenglong Li, Cenap Güngör, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Yuqiang Li
In this study, the potential risk of LN metastasis had a bearing on age, tumor grade, tumor histology, T stage, M stage and tumor size in appendiceal cancer patients. Among them, tumor grade was the most principal hazard factor of LN metastasis in this nomogram. Patients of undifferentiated appendiceal cancer owned the highest risk of LN metastasis which were consistent with most previous studies [24–27]. Moreover, T stage could also be used as an important predictive factors of LN metastasis for appendiceal cancer, which was confirmed by these research of Ryan W. Day and Partelli S [22,28]. The study of Mosquera C et al displayed that tumor size was associated with lymph node metastasis of appendicoma [23]. This study verified that patients with tumors ≥2 cm suffered a higher risk of LN metastasis than those <2 cm. Interestingly, the risk of lymph node metastasis did not increase completely with age. In fact, patients over 80-year old suffered the highest risk of lymph node metastasis but those less than 50 years old not the lowest. Moreover, this study found that lymph node metastasis related to distant metastasis closely. Previous studies also reported that patients' age and distant metastasis were related with LN metastasis in patients with appendiceal cancer [22,23].
Efficacy of preemptive endoscopic submucosal dissection and surgery for synchronous colorectal neoplasms
Published in Scandinavian Journal of Gastroenterology, 2020
Yohei Yabuuchi, Kenichiro Imai, Kinichi Hotta, Sayo Ito, Yoshihiro Kishida, Shoichi Manabe, Yusuke Yamaoka, Hitoshi Hino, Hiroyasu Kagawa, Akio Shiomi, Hiroyuki Ono
The short-term outcomes of surgery after curative ESD are summarized in Table 5. The median operation time was 202.5 min (IQR, 159.5–228) and the median size of the surgically-resected lesions was 27.5 mm (IQR, 18–45). Anastomotic leakage and pulmonary edema occurred in one patient (2.4%) each. Regarding the invasion depth of the lesions, 3 lesions (7.0%) were intramucosal carcinomas, 17 (39.5%) were submucosal invasive carcinomas, and 23 (53.5%) were carcinomas deeper than the submucosal layer. Lymph node metastasis was observed in 13 lesions (31.0%), including distant lymph node metastasis in 1 lesion (2.4%). The pathological stages were as follows: stage 0, 3 patients (7.1%); stage I, 23 patients (54.8%); stage II, 3 patients (7.1%); stage III, 12 patients (28.6%); and stage IV, 1 patient (2.4%).
A systematic review and meta-analysis of long noncoding RNA linc-UBC1 expression and prognosis and clinicopathological phenotypes in human cancers
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Xiewu Zhang, Haibiao Xie, Manjun Luo, Daqiang Liang, Weihua Lao, Weijun Ma, Yankun Lin
With the aging of the population and continuous improvement of medical diagnostic techniques, cancer has become the most dominant public concern in the world and the single barrier to increasing life expectancy worldwide. Based on the estimates of GLOBOCAN 2018, there were approximately 18.1 million new cancer cases and 9.6 million cancer-related deaths worldwide in 2018 [1]. Since 2010, cancer has been the main cause of death in China and other countries [1,2]. For patients with nonmetastatic cancer in the early stage, there are still many treatments, such as radical tumour resection, radiotherapy and chemotherapy, and radiofrequency ablation, to address their disease. However, for patients with advancing tumour stage, the treatments that can be used are still limited [3]. Lymph node metastasis is considered a key predictor of tumour progression and is widely used in clinical prognosis [4]. Additionally, tumour-node-metastasis (TNM) stage has always been identified as a predictive factor of prognosis [5]. Therefore, the identification of predictive factors for the LNM and TNM of tumours are urgent.
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