Melanocytic Neoplasms
Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman in Dermatopathology Primer of Cutaneous Tumors, 2015
Junctional nevus: Lentigo simplex: Lentigo simplex:Variable basal hyperpigmentationIncreased number of single melanocytes in the basal layerNo nest formationMelanoma in situ: Irregular proliferation of nests and single melanocytes in the epidermisSingle melanocytes can be present in the upper levels of the epidermis
Melanomas
E. George Elias in CRC Handbook of Surgical Oncology, 2020
The differential diagnosis of cutaneous melanoma involves other pigmented lesions that may contain melanocytes or hemosiderin. Benign nevi are uniformly colored (tan to brown), have sharp, clear-cut margins, without nodularity, and are usually 0.5 cm or less in diameter. Benign nevi appear during childhood and adolescence and are multiple. By age 20, they may reach 25 to 30 in number, then gradually decrease in number. Pathologically, there are three types of benign nevi: Intradermal nevus can occur anywhere in the body except the palms, soles, and genitalia. Microscopically, benign nests or cords of cells are located in the dermis below the basal cell layer of the epidermis.Junctional nevus can occur anyplace in the body but more often in the palms, soles, and genitalia. Clinically, it cannot be differentiated from the intradermal nevus except by the clinical location. Histologically, nests of cells with occasional clear cells are in the epidermis, and it may involve the basal cells.Compound nevus can be found at any site but mainly on the trunk. Microscopically, it is a combination of intradermal nevus with junctional activity.
Benign Neoplasms
Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang in Roxburgh's Common Skin Diseases, 2022
Clinical presentation: Junctional nevus is a brown-black well-circumscribed macule with a diameter smaller than 0.5 cm. (Figure 19.2)Compound nevus are brown nodules or papules arising from the surface. (Figure 19.3)Intradermal nevus (dermal) is a skin-colored or light-brown polypoid lesions, often without pigment. (Figure 19.4)Variants include balloon cell nevus, inverted type A nevus, eccrine-centric nevus, and Cockade nevus.
A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients
Published in Journal of Cosmetic and Laser Therapy, 2018
Yan Liu, Weihui Zeng, Di Li, Weihua Wang, Feng Liu
Nevus of Ota, also known as nevus fusco-caeruleus ophthalmo-maxillaris, is a benign dermal melanocytic nevus that typically affects Asian children and women, but it has been observed in all races(1). Although mostly it is present in patients at the time of birth, it can also appear later. 80% of the cases occur in females. Unilateral involvement is seen in 95% of the cases(2). Acquired bilateral nevus of Ota-like macules is concomitant with melasma and some other disorders (3). The nevus typically occurs as a persistent, blue-black, or light-brown hyperpigmented macules and patches located along the first and second divisions of the trigeminal nerve. For nevus of Ota occuring on the face, individuals experience mental and psychosocial sufferings of the cosmetic problem and often eager for effective treatment. Based on the principles of selective photothermolysis, nevus of Ota can be treated successfully using the Q-switched (QS) ruby laser, QS alexandrite laser (QSAL), and QS neodymium-doped yttrium aluminium garnet (QSNY) laser (4–6). However, few studies are long-term retrospective of the efficacy and influencing factor, the studies of recurrence are even less.
Microscopic treatment of benign eyelid margin lesions with ultrapulse carbon dioxide (CO2) laser
Published in Journal of Cosmetic and Laser Therapy, 2021
Zhen Mao, Bing-Ying Lin, Yi-Dan Huang, Dan-Ping Huang
Treated areas were less pigmented than the surrounding area in two patients, while the hypopigmentation was mild (Figure 4). No hyperpigmentation was noted. Three patients (3/132, 2.27%) developed a recurrence of melanocytic nevus postoperatively (at 4, 6, and 11 follow-up months respectively). The recurrent nevus appeared as a pigment spot in 2 patients and remained stable in the follow-up period. Therefore, no further laser treatment was performed. For the third patient, we retreated the lesion with the ultrapulse CO2 laser and no relapse occurred furthermore. There were no occurrences of other complications reported before, such as wound infection, eyelid notching, and cicatricial entropion.
Genomic analysis of adult case of ocular surface giant congenital melanocytic nevus and associated clinicopathological findings
Published in Ophthalmic Genetics, 2020
Lindsay A McGrath, Jane M Palmer, Andrew Stark, William Glasson, Sunil K Warrier, Kevin Whitehead, Hayley Hamilton, Kelly Brooks, Peter A Johansson, Nicholas K Hayward
On presentation, best-corrected visual acuity was 6/5 bilaterally. Slit-lamp examination revealed an unstable tear film with punctate corneal erosions. There was gross melanosis of the left upper and lower lids, medial caruncle, canthus, plica, and conjunctiva with medial involvement more marked than lateral involvement (Figure 1a-d). The medial canthus area appeared somewhat suspicious for malignant transformation. Cystic features typical of nevi were also present throughout the conjunctival component of the lesion. Together these findings upheld the provisional diagnosis of a medium congenital melanocytic nevus of the left periocular region with associated GCN.