The Application of Thaw-Mount Autoradiography for the Localization of Putative Estrogen Target Cells in Human Mammary Lesions *
P. Pertschuk Louis, Lee Sin Hang in Localization of Putative Steroid Receptors, 2018
In these experiments several areas of intraductal carcinoma were observed. Some were found to be positive while others were negative. This limited sample would suggest that the cell population of an intraductal lesion can be either ER-positive or -negative and would not support the suggestion of Lee30 that intraductal areas are generally ER-negative. The number of areas sampled in the present investigation was limited, and further studies would be required to draw definite conclusions. A biochemical assessment of intraductal lesions,46 however, has demonstrated a slightly greater proportion of positive cases than was found with infiltrating ductal lesions. The biochemical assay of intraductal lesions could, however, be complicated by the inclusion of associated atypical hyperplastic lesions that, as described in this report, can be ER-positive, possibly resulting in a false biochemical assessment of these lesions.
The Breast
E. George Elias in CRC Handbook of Surgical Oncology, 2020
The demonstration that segmental mastectomy and axillary node dissection, in the management of the infiltrating carcinomas, produced results comparable to modified radical mastectomy makes the evaluation of conservative treatment in these lesions a compelling issue. Therefore, the NSABP has initiated a prospective controlled study (Protocol B-17) to evaluate lumpectomy and axillary dissection with or without radiation therapy to the breast in the management of patients with noninvasive intraductal carcinoma. Such a study will answer few questions with regard to the natural history of the disease, the role of conservative surgery and irradiation, and the incidence of positive axillary nodes in these patients.
Breast cancer
Pat Price, Karol Sikora in Treatment of Cancer, 2014
Most breast malignancies arise from epithelial elements and are adenocarcinomas. Based on the growth pattern and cytologic features of the lesions, in situ carcinomas of the breast are either ductal (also known as intraductal carcinoma) or lobular. Invasive breast carcinomas consist of several histological subtypes; invasive ductal carcinoma accounts for 75%, invasive lobular carcinoma accounts for 8%–10% and medullary carcinoma accounts for 1%–2% of all invasive breast cancers.31 Tubular, mucinous and papillary carcinomas are three other subtypes of invasive breast cancer, which have a better prognosis than other subtypes and together account for 5% of invasive cancers.
A retrospective study comparing different injection approaches of 5-aminolevulinic acid in patients with non-melanoma skin cancer
Published in Journal of Dermatological Treatment, 2022
Weihong Zhao, Jun Wang, Ying Zhang, Baoyong Zheng
Being a retrospective study, the number of patients enrolled in the study was small. Personal history has limited data, for example, immunosuppressive therapy has a significant effect over cancer therapy (6). Treatment efficacy: 69% had a complete response, however, a 6-months follow up is very short. Additional time of follow-up may predict more factors for recurrence (17). It is recommended 12–24 months of follow up, this will be better true efficacy of such treatment. Clinical application of each therapy excluding no, or partial response and recurrence data is required to conclude the study. Most women with Paget disease of the breast also have one or more tumors inside the same breast. These breast tumors are either ductal carcinoma in situ or invasive breast cancer. The status of these women was not reported. The higher the inflammation (pain) of the treatments, the higher the success rate is expected. In this case, the needle-free injection patients had the highest efficacy, the post-treatment inflammation was expected to be higher. The study did not report such a response. The current study has involved a significant number of patients. Academically, the study design is interesting comparing 3 different delivery methods for 5-Aminolevuliniv acid transdermally but clinically, there will be no impact. According to the results of treatment response at 15-days after completion of all cycles, the complete response from each method is 65% (conventional), 66% (plum-blossom needle, and 77% (needle-free), which is hard to take this further for an actionable outcome.
Fertility preservation with random-start controlled ovarian stimulation and embryo cryopreservation for early pregnancy-associated breast cancer
Published in Gynecological Endocrinology, 2019
Nigel Pereira, Isaac Kligman, Rosalie Hunt, Rohini Kopparam, Bridget Wahmann, Zev Rosenwaks
A 34-year-old nulliparous woman had incidentally discovered a breast mass during the fifth week of her pregnancy. She did not have a personal or family history of breast, colon or endometrial cancer. The patient underwent a biopsy of the mass; histopathology revealed an infiltrating intraductal carcinoma, which was estrogen receptor (ER) positive, progesterone receptor (PR) positive and human epidermal growth factor receptor-2 (HER-2) negative. She tested negative for BRCA1 and BRCA2 mutations. Urgent neoadjuvant chemotherapy was deemed necessary. Termination of the pregnancy was offered, which she accepted. The patient presented to our center 5 days after the pregnancy termination to discuss fertility preservation options. Her initial transvaginal pelvic sonogram revealed a thickened endometrial lining and ∼10 antral follicles in each ovary. Her body mass index was 33.3 kg/m2. Her beta-human chorionic gonadotropin (β-hCG) level was 119.8 mIU/mL, progesterone (P) level was 1.2 ng/mL, and anti-müllerian hormone (AMH) level was 3.4 ng/mL on the day of the initial consultation. Fertility preservation options of oocyte and embryo were discussed with the patient and her partner; they chose the latter.
Prostate cancer with cribriform morphology: diagnosis, aggressiveness, molecular pathology and possible relationships with intraductal carcinoma
Published in Expert Review of Anticancer Therapy, 2018
Rodolfo Montironi, Alessia Cimadamore, Silvia Gasparrini, Roberta Mazzucchelli, Matteo Santoni, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli
The differential diagnoses of cribriform PCa include benign (normal central zone glands, clear cell cribriform hyperplasia, basal cell hyperplasia with cribriform pattern) and neoplastic (cribriform high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate) lesions (Table 1). These conditions can be recognized histologically. However, the distinction between small cribriform PCa (GP 3 in 2005 ISUP classification) and cribriform high-grade prostatic intraepithelial neoplasia may be difficult and is based on the absence or presence of basal cells investigated immunohistochemically. When cribriform and intraductal carcinoma cannot be distinguished morphologically, immunohistochemistry for basal cell markers needs to be applied especially if the tissue originates from a biopsy. The presence of basal cells supports a diagnosis of intraductal carcinoma of the prostate (IDC-P).
Related Knowledge Centers
- Apocrine
- Breast
- Breast Cancer Screening
- Cancer
- Male Breast Cancer
- Lactiferous Duct
- In Situ
- Grading
- Comedocarcinoma
- Mammography