Primary Meningioma of the Nasal Cavity and Paranasal Sinuses
Gerd Reznik, Sherman F. Stinson in Nasal Tumors in Animals and Man, 2017
Angioblastic meningioma — This comprises a less well-defined group. They are highly cellular with prominent vascular channels (Figure 9). Cellular pleomorphism and mitotic figures are not infrequent. Foamy, lipid-laden cells may be seen in the stroma. Abundant reticulin fibers are commonly found in the vessel walls and stroma (Figure 10). It is a generic term to include hemangiopericytoma and transitional forms between hemangiopericytoma, hemangioblastoma, and classic meningioma with abundant vascular channels (Figure 11).48,49 Despite investigations made with tissue culture, ultrastructural, and immunological techniques, a lack of agreement still exists as to whether these three tumors represent separate entities or merely variants of a single type of neoplasm.50,52
Sarcomas
E. George Elias in CRC Handbook of Surgical Oncology, 2020
Tumors of vascular endothelial origin—include angiosarcoma, lymphangiosarcoma, and hemangiopericytoma. Angiosarcomas are common in elderly people in the scalp. They also do occur in the skin, breast, and the liver (Figure 1). Vinyl chloride exposure has been blamed as etiological factor. They have a spongy or blood blister appearance. Lymphangiosarcoma is a rare tumor that used to be frequently seen in the arms of patients who underwent a radical mastectomy and radiation therapy. It arises in a long standing lymphatic obstruction of 10 to 20 years (Figure 2). The survival is poor and lung metastases are common. Hemangiopericytomas do occur in all age groups and sites, but mainly in the lower extremities and retroperitoneum and pelvis. Histologically, this tumor may mimic synovial sarcoma.
Primary Pleuropulmonary Synovial Sarcoma: Report of Two Cases and a Comprehensive Review of the Literature
Published in Cancer Investigation, 2022
Neda Khalili, Elham Askari, Nastaran Khalili, Aboulghasem Daneshvar-Kakhki, Makan Sadr, Sara Haseli, Mihan Pourabdollah Toutkaboni
Histologically, SSs are divided into four categories: monophasic fibrous, monophasic epithelial, biphasic and poorly differentiated. More precisely, poorly differentiated tumors can actually develop in either the monophasic or biphasic subtype, and can be regarded as a form of tumor progression rather than a distinct subtype (34). The biphasic tumor type could be readily diagnosed since it consists of two components: epithelial cells and spindle-shaped cells. Monophasic fibrous SS, the most common subtype, exhibits uniform spindle cell fascicles arranged in a herringbone or interweaving pattern that may be accompanied by small areas of cells with epithelioid-like morphology. Poorly differentiated tumors generally have hemangiopericytoma-like vascular patterns. In addition, these tumors may have high mitotic counts, and may present with three prototypic forms: (1) a large cell or epithelioid pattern constituting rounded nuclei of varying size with prominent nucleoli, (2) a small cell pattern with nuclear features similar to other small round cell tumors and (3) a high-grade spindle cell pattern composed of spindle-shaped cells with high-grade nuclear features and a high mitotic rate, often accompanied by necrosis (34,35). According to the results of this review, the most frequently observed subtype was the monophasic fibrous, which constituted about 70% of all reported cases. The two latter subtypes were less often reported, and no case was documented as monophasic epithelial SS.
Non-islet cell tumor-induced hypoglycemia in the setting of metastatic intracranial hemangiopericytoma: case report and review of the literature
Published in British Journal of Neurosurgery, 2023
Leslie A. Nussbaum, Rebecca M. Walton, Eric S. Nussbaum
We present our experience with a patient presenting with hypoglycemia and abnormal IGF-1, IGF-2, C-peptide, and insulin levels resulting from a recurrent intracranial hemangiopericytoma with extracranial metastatic disease. Surprisingly, despite the fact that hemangiopericytoma is often managed primarily by neurosurgeons, this phenomenon has not been described in the neurosurgical literature; and, therefore, many neurosurgeons are unfamiliar with hypoglycemia as an important warning sign of recurrent disease. In addition, patients with severe hypoglycemia may present with neurologic deficit,7–9 unconsciousness, or even death.10,11 These symptoms, in the patient with a prior history of a brain tumor, may be mistaken for seizure activity; and, as a result, the significance of the hypoglycemia may be unappreciated, and the presence of the metastatic disease may be missed.
Intracranial hemangiopericytoma after radiation treatment: first case in the literature
Published in British Journal of Neurosurgery, 2023
Gulden Demirci Otluoglu, Emre Zorlu, Baran Yılmaz, Akın Akakın, Ozlem Yapıcıer, Turker Kilic
A twenty-five-year-old male patient was admitted with sudden onset headache, upward gaze palsy and altered consciousness. Magnetic Resonance (MR) showed a heterogeneously enhancing lesion in the pineal region and hydrocephalus. He had a VP shunt surgery first and then a left occipital craniotomy and a gross total excision of the tumor. Histology was of a pineoblastoma. In the post-operative period, he had radiotherapy with IMRT (Intensity Modulated Radiation Treatment) method (6000 cGy in 30 fractions). Forty-one month later he had a new extra-axial lesion heterogeneously enhancing in the right parietal parafalcine area. Second surgery was performed via right parietal craniotomy and gross total excision was achieved (Figure 1). Histology was of cellular mesenchymal tumor composed of fibroblastic type cells showing a rich thin-walled branching staghorn-like vessels. Tumor showed a delicate and rich network of reticulin fibers typically investing individual tumor cells. A mitotic count of 3 mitoses per 10 high-power fields was seen. Necrosis was not identified. Immunohistochemical analysis was carried out. Epithelial membrane antigen (EMA), progesterone receptor (PR) and Glial fibrillary acidic protein (GFAP) immunostains were negative. Tumor cells were only positive for CD34 and STAT6. The diagnosis was consistent with hemangiopericytoma, grade II (David N. Louis6) (Figure 2). He had adjuvant radiotherapy again with IMRT (Intensity Modulated Radiation Therapy) method to the second surgical excision area (5000 cGy in 30 fractions). He is now under follow up without any new intracranial lesion or extracranial metastasis 42 months since his last surgery.
Related Knowledge Centers
- Meninges
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- Capillary
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- Soft-Tissue Sarcoma
- Retroperitoneal Space
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