Vitiligo and Associated Comorbidities
Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan in Comprehensive Textbook on Vitiligo, 2020
The association between vitiligo and halo nevi is well established. Several reports have documented the onset of vitiligo at the same time or shortly after the appearance of a halo nevus and, in a recent study, halo nevi were present in 31.1% of all vitiligo patients [1]. Halo nevus (HN), also known as Sutton's nevus or leukoderma centrifugum acquisitum, is a benign, mostly acquired, melanocytic nevus surrounded by a halo of depigmentation [17]. HN may be single, or multiple HN may be observed. The main localization of HN is the trunk [18]. Family history is mostly negative, but in some cases of HN, vitiligo, atopic dermatitis, or autoimmune disorders, mainly Hashimoto thyroiditis, have been reported in relatives. Some authors suggest that even if the exact etiology of halo phenomenon and vitiligo remains uncertain, a common immunologically-mediated response to pigmented cells might be considered [19].
Childhood versus post-childhood vitiligo
Electra Nicolaidou, Clio Dessinioti, Andreas D. Katsambas in Hypopigmentation, 2019
A halo nevus (Figure 7.4), also termed Sutton's nevus, is a melanocytic nevus that is surrounded by a depigmented rim. The presence of halo nevi in children with vitiligo varies greatly among different countries and races: 2.5% in a study from Korea,8 7.2% in a Chinese study,12 18.4% in a study from France,26 and 26% in a study from the United States.27 An Italian study that included 27 children with halo nevi and vitiligo reported that in 11 children (40.7%), the appearance of halo nevi and vitiligo was almost simultaneous; in 9 children (33.3%), halo nevi preceded vitiligo; while in 7 children (25.9%), halo nevi followed the onset of vitiligo.28
Benign Neoplasms
Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang in Roxburgh's Common Skin Diseases, 2022
Differential diagnosis: In patients who present with a halo nevus at an older age, melanoma of any location should be suspected. As compared with the symmetry found in the halo nevus, an asymmetric, irregular halo may be seen with melanoma, but asymmetry does not equate with malignancy. Melanoma is typified by other attributes such as generally >1 cm in size, irregular or notched borders, and marked color irregularity. Multiple halo nevi may be a sign of ocular or cutaneous melanoma elsewhere, particularly in older adults.
The landscape of vitiligo in Latin America: a call to action
Published in Journal of Dermatological Treatment, 2023
Angela Londoño-Garcia, Andrea Arango Salgado, María de la Luz Orozco-Covarrubias, Angela Marie Jansen, Mariana Rico-Restrepo, María Cecilia Riviti, Margarita María Velásquez-Lopera, Carla Castro
The genetic and environmental causes of vitiligo are well-documented, but the underlying mechanisms are complex (8). Despite the lack of genetic investigations in LA, a positive family history of vitiligo was discovered in patients from Colombia (15%), Brazil (18%), and Mexico (26%) (8,15,16). Children with vitiligo in Mexico have a familial history among first- (73%) and second-degree relatives (27%) (17). A personal or familial history of autoimmune diseases is associated with more severe forms of vitiligo (18). Monozygotic twins had a concordance rate of only 23%, highlighting the influence of the environment on vitiligo development (19). Emotional stress is believed to be a trigger, but data remains limited (8). In a study of 701 Brazilian children, 67% of cases of vitiligo were induced by emotional causes (15). Physical trauma is also a trigger for vitiligo, as demonstrated by Koebner’s phenomenon, a sign of disease activity (8). Additionally, halo nevus is a risk factor for vitiligo (15,20). Low socioeconomic status may influence disease control, treatment adherence, QoL declines, and heightened stigmatization.
Management of resistant halo nevi
Published in Journal of Cosmetic and Laser Therapy, 2019
Sherif S Awad, Rasha TA Abdel Aziz, Sahar S Mohammed
Halo nevus (HN), also termed leukoderma acquisitum centrifugum or Sutton’s nevus, is usually a benign pigmented melanocytic nevus surrounded by a depigmented ring (1,2). It has an incidence of 1% in the general population. The mean age of onset is 15 years, and it occurs equally in males and females. The nevus itself is most commonly acquired, but rarely develops around congenital nevi. Patients may have one or multiple halo nevi, and the most common location is on the trunk.
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