Ayurveda and COVID-19
Srijan Goswami, Chiranjeeb Dey in COVID-19 and SARS-CoV-2, 2022
The CNS consists of the brain, the cranial nerves, the spinal cord, and a network of nerves that connects every organ of the body to the brain. There are two main branches of the CNS—sensory and motor. Sensory nerves carry sensations to the brain and motor nerves carry instructions from the brain to the organs and muscles. The network of sensory nerves collects sensations from all the sensory organs (eyes, ears, nose, tongue, and skin) from all over the body and carries them to the brain. The brain compiles all the sensations and creates a complete picture. The picture is compared with the memory of past events and a line of action is decided upon. The brain then sends instructions to the organs of action through the network of motor nerves. All this activity happens at lightning speed. This is how all voluntary action takes place.
Functional Neurology
James Crossley in Functional Exercise and Rehabilitation, 2021
Neurons clump together to form nerves. Nerves can be either sensory, motor or interconnecting. Sensory nerves, also known as afferent nerves, relay signals from the peripheral tissues and organs to the central nervous system (CNS). Afferent nerves provide the CNS with information regarding our environment. Motor, or efferent nerves, transmit signals from the CNS to the tissues and organs. These signals ‘activate’ or alter the function of peripheral tissues and organs. Motor signals sent from the CNS innervate muscles, making them contract, for example. Interneurons are so called because they communicate between or connect spinal and motor neurons, influencing and modulating neuronal function on yet another level. Nerves congregate in various areas of the body, the entirety of which we call the nervous system.
Diabetes
Sally Robinson in Priorities for Health Promotion and Public Health, 2021
Sensory nerves are those that allow people to feel pain, touch and temperature as well as other sensations from bones, muscles and skin. If these nerves are damaged, a person may experience numbness, tinglingan absence of pain or shooting/burning painsan inability to detect changes in temperatureloss of coordination as the position of joints becomes unclear
Safety considerations with the current treatments for peripheral T-cell lymphoma
Published in Expert Opinion on Drug Safety, 2022
Tarsheen Sethi, Francesca Montanari, Francine Foss
Brentuximab vedotin (BV) is recombinant antibody drug conjugate (ADC) targeting the CD30 receptor, which is expressed on Hodgkin’s Disease, subsets of T-cell lymphomas, and activated T cells. The single chain anti-CD30 antibody is conjugated to monomethylauristatin E, a potent antitubulin agent. The maximum tolerated dose (MTD) of BV was established to be 1.8 mg/kg every 3 weeks based on a phase 1 study of 45 patients with R/R CD30+ lymphomas [14]. Major toxicities included fatigue (36%), fever (33%), diarrhea, nausea, neutropenia, and peripheral sensory neuropathy (PSN) (22% each). Two subsequent Phase II studies in patients with R/R Hodgkin’s Disease and anaplastic large cell lymphoma led to FDA approval of the drug for these two indications [15,16]. In the ALCL study, 53 patients were treated with BV at a dose of 1.8 mg/kg every 3 weeks; in the study patients received up to 16 doses. The ORR was 86%, with 57% CR [15], the median DOR was 12.6 months, and the median PFS was 13.3 months. The most frequent AE was neuropathy which was mainly in peripheral sensory nerves and occurred in up to 41% of patients. Other AEs included constitutional symptoms such as nausea, fatigue, and fever, and cytopenias (21% neutropenia, 14% thrombocytopenia, 7% anemia). Neuropathy was grade 3/4 in 21% of patients. The 5-year OS was 60% with interim negative PET scan (after cycle 4) associated with a better prognosis.
Exploring the neuroregenerative potential of tacrolimus
Published in Expert Review of Clinical Pharmacology, 2019
T. M. Saffari, M. Bedar, J. M. Zuidam, A. Y. Shin, C. C. Baan, D. A. Hesselink, C. A. Hundepool
Few clinical trials have explored the neuroregenerative effect of tacrolimus and contrary to the expectations, no evident increase in regeneration has been quantified [117]. Tacrolimus was included in the treatment of the first successful hand transplantation patient and still postulated to have contributed to the median and ulnar nerve regeneration [99]. This nerve recovery is also suggested to accelerate sensory nerve regeneration after facial transplantation [118]. The incidence of successful VCA, in particular, hand- and facial transplants are predicted to increase over the next decade. Off-the-shelf available allografts with or without locally delivered immunosuppression that could enhance neuroregeneration would revolutionize the management of complex peripheral nerve injuries.
Disease related changes in vocal parameters of patients with type 2 diabetes mellitus
Published in Logopedics Phoniatrics Vocology, 2022
Hakan Gölaç, Güzide Atalik, Alper Kutalmış Türkcan, Metin Yilmaz
As the duration of diabetes progresses, various disease related complications might occur in patients with DM. These complications significantly affect the patient's quality of life with various diabetic symptoms [5]. The resulting complications could be seen at micro (damage of small blood vessels) or macrovascular (damage of the arteries) level. Microvascular complications consist of “retinopathy” “nephropathy” and “neuropathy” [6]. It has been stated that almost half of all individuals with diabetes eventually develop neuropathy [7]. It is known that neuropathy is characterized by numbness, tingling, and pain sensations in the extremities and it may affect the sensory nerves.
Related Knowledge Centers
- Central Nervous System
- Motor Nerve
- Neural Pathway
- Peripheral Nervous System
- Sensory Neuron
- Nerve
- Afferent Nerve Fiber
- Mixed Nerve
- Sensory Nervous System
- Efferent Nerve Fiber