Acne, rosacea and similar disorders
Ronald Marks, Richard Motley in Common Skin Diseases, 2019
The acute episodes of inflammation can be calmed with systemic tetracycline, erythromycin or metronidazole, using the full antibacterial dosage until the condition improves and then a dose sufficient to maintain improvement. Initial improvement usually occurs within the first 3–4 weeks of treatment. It would be typical for a patient to start tetracycline 250 mg 6-hourly for 3 weeks and then receive the drug three times daily for a further 3 or 4 weeks. At that time, reduction to twice-daily dosage would be made and maintained until stopping (perhaps at 10–12 weeks) did not result in the appearance of further papules. Minocycline or doxycycline 50 mg once or twice per day is more convenient. Erythromycin is also effective and the same dose regimen applies as for tetracycline. Clarithromycin has also been reported to be effective. Metronidazole is not often given because of its side effect profile. It has a disulfiram-like effect, causing alcohol intolerance. Other side effects include nausea and blood dyscrasias.
Narratives: Listening to Patients
John K. Crellin, Fernando Ania in Professionalism and Ethics in Complementary and Alternative Medicine, 2012
Within weeks, I was overwhelmed with remedies. A woman who had been ill for nine years wrote to recommend that 1 begin smoking cigarettes. “I decided that perhaps nicotine would kill the virus,” she said, “and started smoking again on the order of a pack a day. I began to recover and it seems to me that my symptoms worsen when 1 smoke less.” Though she said it's worth a try, this was one remedy I decided to pass over. Another woman sent me cassette tapes she recorded on using creative imagery to help me overcome the trauma that must be the underlying cause of my ailment. Her wheezy, rasping voice moved me because of the enormous effort that recording these tapes must have taken. Another wrote to suggest coffee enemas and full spectrum lights, which, she said, “recharge the looker.” She also thought ! might benefit from taking a certain immune system modulator which she had gotten from her veterinarian. Think about it. A Captain took the time to write from aboard his vessel near Nigeria, recommending a sugar cane rum remedy given to him by a macumba priestess in Brazil. I should take one tablespoon of the concoction after getting up in the morning. Then, he advised, “it might be better to lie down for an hour. It is a mighty powerful drink.” He also advised me to brush my teeth when the hour was up. Since alcohol intolerance is strongly associated with Chronic Fatigue Syndrome, I regretfully set this suggestion aside….
PCV (procarbazine, lomustine [CCNU®], vincristine)
Maxwell Summerhayes, Susanna Daniels in Practical Chemotherapy, 2018
Bone-marrow suppression (late and sometimes prolonged with lomustine), alopecia (this regimen is commonly used after cranial irradiation, which is already likely to have caused hair loss, so this may not be an issue), nausea and vomiting, mucositis. Peripheral neuropathy due to vincristine. Procarbazine is a weak inhibitor of MAO, and can lead to CNS side-effects such as somnolence, hallucinations, ataxia, headache and insomnia, especially when administered with tyramine-rich foods, alcohol or interacting medications. It also has a weak disulfiram-like effect and may lead to alcohol intolerance. Lomustine can cause pulmonary dysfunction (shortness of breath, decreased diffusion capacity, fibrosis) after high cumulative doses (lifetime treatment doses should not exceed 1100–1400 mg/m2).
Evaluating case diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): toward an empirical case definition
Published in Disability and Rehabilitation, 2023
Karl E. Conroy, Mohammed F. Islam, Leonard A. Jason
The preliminary EFA yielded a six-factor solution. The following items were dropped from the analysis due to low factor loadings: need to nap daily, sensitivity to lights, losing or gaining weight without trying, sensitivity to noise, muscle weakness, some smells, foods, medications, or chemicals make you feel sick, bladder problems, night sweats, muscle twitches, joint pain, no appetite, muscle pain, loss of depth perception, and sleep all day/stay awake all night. The item alcohol intolerance was dropped due to a low factor loading and a low communality score (<0.20). Sufficient inter-item correlations were observed from the correlation matrix. Moreover, multicollinearity was not observed (>0.80). Bartlett's test of sphericity for the correlation matrix was significant (χ2 (741)=45577.56, p< 0.001) and the Kaiser–Meyer–Olkin measure of sampling adequacy (KMO = 0.953) also indicated that the matrix was appropriate for EFA.
Unwanted Sex Due to Intoxication among Australians Aged 16–69 Years
Published in The Journal of Sex Research, 2021
Allison Carter, Christy Newman, Richard de Visser, Anna Yeung, Chris Rissel, Andrew Grulich, Bridget Haire, Deborah Bateson, Cathy Vaughn, Kevin McGeechan, Basil Donovan, Juliet Richters, Rebecca Guy
Interestingly, though, heavy drinking was independently associated with unwanted intoxicated sex in women only in our study. Past research has found that women who are heavy drinkers are more likely to report that sex feels easier with alcohol, and to regret sex and partner choice after drinking (Connor et al., 2015; Mallett et al., 2006). An advantage of drawing on assemblage theory to interpret these results is that it provides a framework for thinking about how biological, psychological, and social-relational forces may work together to increase this likelihood for women but not men, such as lower alcohol intolerance (Moinuddin et al., 2016), sexual scripts (Farris et al., 2010, 2008; Lindgren et al., 2008), and rape myths (Webster et al., 2018). Conversely, the associations seen with injection drug use and smoking behavior in men, which is inversely related to socio-economic status in Australia (Siahpush, 2004; White, 2003), have not been previously documented.
Optimizing non-opioid pain control after implant-based breast reconstruction: a review of the literature and proposed pain control algorithm
Published in Journal of Plastic Surgery and Hand Surgery, 2020
Jeremie D. Oliver, Rebecca Knackstedt, James Gatherwright
Non-steroidal anti-inflammatory (NSAID) medications have been used as adjuvant pain control medications for most enhanced recovery protocols. Despite previous concerns regarding increased bleeding risk, multiple studies have failed to demonstrate a causative link [23,38]. Main contraindications to NSAID pharmacotherapy would include patients with a history of peptic ulcer disease, gastrointestinal bleeding, alcohol intolerance, renal impairment, or cerebrovascular bleeding (see algorithm, Figure 2). In addition to NSAID therapy, acetaminophen has been suggested as a helpful and safe adjunct to perioperative pain management protocols in breast reconstruction. Acetaminophen use, compared to placebo, has been shown to significantly reduce postoperative pain in surgical patients, both on its own, as well as in combination at various dosages with NSAIDs, lending additional evidence to support the concept of multimodal analgesia protocols [8,9].
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