Sensor-Enabled 3D Printed Tissue-Mimicking Phantoms: Application in Pre-Procedural Planning for Transcatheter Aortic Valve Replacement
Ayman El-Baz, Jasjit S. Suri in Cardiovascular Imaging and Image Analysis, 2018
3D printing features a high ability for customization, high geometrical complexity, and cost effectiveness in manufacturing cases with low production volume, which is perfectly suited for biomedical applications like prosthetics implants [33], orthopedic implants [7], [34], [35], and tissue/organ printing [8], [36], [37]. Bose et al. did a comprehensive review of cases where additive manufacturing technologies were applied in bone tissue engineering [38]. In some of those cases, multiple types of materials, including ceramics and polymers, were used to tune the mechanical properties of the printed scaffolds. Biglino et al. demonstrated the fabrication of compliant arterial phantoms with PolyJet technology, an additive manufacturing technique that deposits liquid photopolymer layer by layer through orifice jetting and then solidifies by UV exposure [39]. A rubber-like material named TangoPlus (Stratasys Ltd) was used in this study because its mechanical properties are similar to the real tissue. Cloonan et al. did a comparative study on common tissue-mimicking materials and 3D printing materials including TangoPlus with the abdominal aortic aneurysm phantoms [40]. Their results suggested that TangoPlus was a suitable material for modeling arteries in terms of dispensability and it outperformed poly (dimethylsiloxane) (PDMS) Sylgard elastomers that were commonly used in the investment casting process in terms of uniaxial tensile properties.
Three-Dimensional Printing: Future of Pharmaceutical Industry
Harishkumar Madhyastha, Durgesh Nandini Chauhan in Nanopharmaceuticals in Regenerative Medicine, 2022
The use of 3D printing in medicine is now close to become a reality. 3D printing consists of three main pillars: one is to utilise less time, second is to treat a large number of people, and third is to receive more outcome. In brief, 3D printing is made up of one sentence ‘enable less physicians to treat more patients without any scarification of results’. 3D printing has opened new ways for the pharmaceutical industry. The on-demand printing of medicines is possible by emailing their database of medicines to pharmacies, which further help the pharmaceutical sector in formulating a cost-effective method of manufacturing and distributing of medicines. The medicines made by this way will increase the patient adherence. In future, it may lead to development in garage biology. As this technique is latest, so due to no regulation, security and safety are required for 3D printing. As a latest technique, 3D printing has proposed many applications in the medical sector. A new door has opened to a newer generation of advanced system of drug delivery by combination of the conventional method of manufacturing in the pharmaceutical industry with 3D printing. We believe that perseverance and patience in 3D printing can develop a safe and effective system of pharmaceutical dosage form.
Applications of Rapid-Prototyping Methods in Forensic Medicine
Michael J. Thali M.D., Mark D. Viner, B. G. Brogdon in Brogdon's Forensic Radiology, 2010
Traditional Computer Numerical Control (CNC) milling machines provide a means of creating a 3D model out of a material block. This technique, however, fails to create struc-tures that are occluded, such as cavities (Klein, 1992). In 1986, the idea of generating real 3D models based on virtual 3D data evolved into stereolithography (Dolz, 2000). Stereolithography builds up a model layer by layer by hard-ening a liquid-acrylic resin with an ultraviolet laser beam (Hull, 1986). Unlike CNC milling, this technique is limited to a specific material but allows for the generation of closed cavities and fine structures. Models generated with stereo-lithography are durable but lack color information. The sec-ond most-commonly used method is called 3D printing. It is a relatively new technology and allows the generation of colored 3D models. These systems create layers of powder that are fixed selectively by a binder (Figure 30.1). Comparable to standard ink printers, color can be added to the binder. While stereolithography has an accuracy of 0.1 mm, 3D printing can print structures up to 0.016 mm depending on the particle size of the powder and the binder used. The costs of a 3D printed model are approximately one-third of those for a stereolithographically generated model (Cohen, 2009).
Intervention of 3D printing in health care: transformation for sustainable development
Published in Expert Opinion on Drug Delivery, 2021
Sujit Kumar Debnath, Monalisha Debnath, Rohit Srivastava, Abdelwahab Omri
Rapid prototype (RP) is mainly dealing with the 3D process. This is not similar to subtractive processes like cutting, sanding, knurling, drilling, or deformation, facing, turning to create a structure by axis rotation. The accumulation layer in the x-y direction in a precise way develops a 2D structure. The addition of the third axis (z) helps to construct a multilayer assembly vertically. With a complex and fine ‘z’ steeping, a prototype shape becomes unique. The 3D printing process is composed of two different crucial models as mathematical and physical layer models. 3D printing is a layer-by-layer manufacturing process that develops a physical model with the use of CAD [2]. Like CAD, computer-aided engineering (CAE), computer numerical control (CNC), and computer-aided manufacturing (CAM) software develop computer models and distance information of real objects that are finally processed by a computer [3]. Standard Tessellation Language (STL) file was developed by 3D Systems Inc. in 1987. This file is standard for each 3D printing process. This STL file converts the geometry in the CAD file into a header and coordinates between vector triangles (x, y, and z). This 3D printing technology followed some basic phases that have been mentioned in (Figure 1). The manufacturing settings are highly crucial for any fabrication. These settings mainly depend on the type of machine and software used. This manufacturing setting could be categorized into four types as energy, scan, powder, and temperature-related [4].
Development of filaments for fused deposition modeling 3D printing with medical grade poly(lactic-co-glycolic acid) copolymers
Published in Pharmaceutical Development and Technology, 2019
Tim Feuerbach, Sara Callau-Mendoza, Markus Thommes
In the pharmaceutical and medical research field, three-dimensional (3D) printing is emerging as a possible manufacturing process for drug dosage forms (Goyanes et al. 2014; Zema et al. 2017) and implants (Espalin et al. 2010; Vorndran et al. 2015). Advantages include the personalization of drug dosages, release profiles (Khaled et al. 2015a; Genina et al. 2016) and implant geometry (Melgoza et al. 2014; Thomas and Singh 2017). In 3D printing, 3D objects are manufactured layer by layer, based on digital models of the respective objects (Gibson et al. 2015). Due to its unique manufacturing technique, 3D printing is expected to have a significant impact on the pharmaceutical and medical manufacturing processes (Ventola 2014). Fused deposition modeling (FDM) is a promising extrusion-based 3D printing technique (Masood 2007; Goyanes et al. 2015) in which the individual layers of the printed object consist of extruded thermoplastic material strands (Gibson et al. 2015). Recent publications showed a broad field of potential applications for products manufactured by FDM, such as drug-eluting implants (Water et al. 2015; Kempin et al. 2017), functional medical devices (Sandler et al. 2014; Hollander et al. 2016), or tablets with multiple compartments and modified release kinetics (Khaled et al. 2015b; Park 2015), to mention a few examples.
Collective making: Co-designing 3D printed assistive technologies with occupational therapists, designers, and end-users
Published in Assistive Technology, 2023
Leila Aflatoony, Su Jin Lee, Jon Sanford
The study results reveal the potential for co-designing 3D-printed assistive writing devices with unique attributes and qualities by providing equal opportunities to OTs, designers, and the end-user for exchanging their clinical-technical-individual insights, knowledge, and expertise during the participatory workshops. Our findings corroborate several previous studies that explored the advantages of integrating diverse backgrounds and expertise in co-designing ATs through collaborative and participatory activities (Hofmann et al., 2019; Martinez et al., 2016; Sarmiento-Pelayo, 2015; Wagner et al., 2018). Additionally, our study illustrated the advantages of 3D printing in developing usable AT solutions (Buehler et al., 2016; Buehler, Hurst, et al., 2014; Buehler, Kane, et al., 2014; Degerli et al., 2020; Thorsen et al., 2019). While OTs recognized the benefit of 3D printing, they vocalized the challenges, nuances, and limiting factors in utilizing these technologies (Buehler et al., 2014a; McDonald et al., 2016).
Related Knowledge Centers
- Mental Model
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