Use of Dermatologics during Pregnancy
“Bert” Bertis Britt Little in Drugs and Pregnancy, 2022
Podophyllin is a topical agent used to treat condyloma acuminata. A solution of 20 percent podophyllin solution in tincture of benzoin is used to treat condyloma. Use of podophyllin during pregnancy is associated with significant edema, skin irritation, and discomfort. The frequency of birth defects was not increased in frequency among 14 infants whose mothers used podophyllin during the first trimester (Heinonen et al., 1977), but this sample was too small to interpret. Several anecdotal reports of maternal and fetal toxicity include a case of fetal demise in a mother who experienced systemic toxicity following the topical application of podophyllin (Gorthey and Krebs, 1954) and others that reported similar adverse effects (Chamberlain et al., 1972; Slater et al., 1978).
Cidofovir and Brincidofovir
M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson in Kucers’ The Use of Antibiotics, 2017
A group of patients treated with CDV for anogenital condylomata was compared with a group treated by electrocoagulation; the authors concluded that topical applications of CDV were active in a majority of patients with such lesions (Coremans et al., 2003). Following these studies, CDV may be recommended as a valuable adjuvant to the surgical treatment of anogenital condylomata (Coremans et al., 2003). CDV has increasingly been used as therapy for severe recurrent anogenital warts associated with the low-risk HPV types (Coremans and Snoeck, 2009; Gormley and Kovarik, 2012). The potential role of topical CDV in maintaining remission of giant condyloma acuminatum in an immunocompromised host, used in conjunction with surgical excision and high-dose interleukin 2 immunotherapy, has been also described (Nambudiri et al., 2013).
Cancers of the Vulva and Vagina
Jennifer L. Kelsey, Nancy G. Hildreth in Breast and Gynecologic Cancer Epidemiology, 2019
Condyloma acuminatum, a genital wart induced by a papillomavirus, has been suspected as an etiologic factor in vulvar carcinoma. These warts have been noted to occur in 5 to 14% of women with cancer of the vulva, and the carcinoma often appears to arise within these warts, which may have been present for a number of years.14,15 Cancer of the vulva tends to be diagnosed at an earlier age among women with associated condyloma acuminatum than in women without these warts.14 One study18 found that among 53 women with carcinoma in situ of the vulva, 30% had evidence of a previous or current infection of the vulva that could be attributed to either herpes or condyloma virus.
Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses
Published in International Journal of Hyperthermia, 2019
Yu-Zhe Sun, Jia-Feng Li, Zhen-Dong Wei, Hang-Hang Jiang, Yu-Xiao Hong, Song Zheng, Rui-Qun Qi, Xing-Hua Gao
Condyloma acuminatum (CA) is a common, sexually-transmitted disease observed worldwide that develops from human papillomavirus (HPV) infection. Among all HPV subtypes, CA is primarily the result of either a HPV 6/11 (low-risk types) or HPV 16/18 (high-risk types) infection [1]. CA patients are typically treated with physical therapies such as CO2 laser ablation and cryotherapy, however, recurrence is oftentimes observed due to failures in eliminating invisible HPV-infected loci [2]. Although 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective in treating latent HPV infection and reducing recurrence of CA [2], the relatively high medical expenses and pain associated with this therapy limits its application, especially in patients with massive lesions. Therefore, there exists a clear need for the development of more effective and economic therapeutic methods.
CO2 laser treatment for pearly penile papules – personal experience
Published in Journal of Cosmetic and Laser Therapy, 2019
Anna Deda, Aleksandra Lipka-Trawińska, Sławomir Wilczyński, Barbara Błońska-Fajfrowska
The lesions, prior to their removal, were diagnosed, including differential diagnosis for condyloma acuminata and molluscum contagiosum (11). PPP do not contain human papilloma virus and there is no relationship between the occurrence of condyloma and PPP (21). Molluscum contagiosum can be distinguished clinically from PPP based on umbilicated papules that are larger in size (3). In the dermoscopic image, PPP resemble grape-shaped structures where each lesion contains characteristic blood vessels in the shape of dots or commas (19,22). However, it should be noted that this vascular pattern is not characteristic and can also be observed in the case of condyloma (22,23). Nevertheless, PPP have a more homogeneous structure in the dermoscopic image due to the absence of exfoliation (23).
Rapid detection and subtyping of human papillomaviruses in condyloma acuminatum using loop-mediated isothermal amplification with hydroxynaphthol blue dye
Published in British Journal of Biomedical Science, 2018
Q Zhong, K Li, D Chen, H Wang, Q Lin, W Liu
Human papillomavirus (HPV) is a small DNA virus. More than 140 types of HPV have been identified [1] and classified as low-risk or high-risk carcinogenic types, according to their oncogenic potential [2]. The most common high-risk HPVs are types 16 and 18, which are responsible for >70% of cervical cancers and other anogenital carcinomas in women and men, as well as oropharyngeal tumours [3]. Condyloma acuminatum (CA) is a benign tumour caused by infection of the cutaneomucous regions of the genital and anal areas with low-risk HPVs such as HPV-6 or HPV-11 [4]. Histopathological diagnosis and virological testing are required in the clinical diagnosis of CA, and, with identification of the genotype if possible [5]. Various methods are currently used to identify HPV infections. Polymerase chain reaction (PCR) is highly specific and sensitive, but is time-consuming and requires extensive laboratory equipment [6]. Immunohistochemistry is relatively inexpensive, but the sensitivity and specificity are lower than PCR [7, 8]. Luminex suspension array technology, which combines PCR with hybridization to fluorescence-labelled polystyrene bead microarrays, has also been used for the clinical detection of HPV genotypes [9], but is time-consuming, costly and requires specialized equipment. These limitations of existing methods mean that the CA patients need a sensitive, specific, rapid and cost-effective assay for determining HPV genotype [10].
Related Knowledge Centers
- Biopsy
- Oral Sex
- Wart
- Sexually Transmitted Infection
- Papillomavirus Infection
- Sexual Intercourse
- Anal Sex
- Hpv Vaccine
- Condom
- Podophyllum Resin