Tea Polyphenolic Compounds against Herpes Simplex Viruses
Satya Prakash Gupta in Cancer-Causing Viruses and Their Inhibitors, 2014
Because HSV primarily affects skin, mucous membranes, and neurons, this herpesvirus often results in oral, facial, pharyngeal, ocular, and central nervous system infections. Primary and recurrent infections generally produce the same symptoms with the exception that recurrent infections are often milder and persist for a shorter amount of time as compared to primary infections. HSV infections can result in primary herpetic gingivostomatitis (PHGS), herpes simplex labialis (HSL), recurrent intraoral herpes (RIH), genital herpes, Kaposi’s varicelliform eruption (KVE), herpes gladitorum, herpetic whitlow, ocular herpes, encephalitis, and neonatal herpes. An individual’s symptoms of these various HSV manifestations may vary according to one’s genetic makeup, immune status, site of infection, and dose of inoculum (Fatahzadeh and Schwartz 2007; Huber 2003; Lin et al. 2011).
Primary Herpes Simplex Gingivostomatitis and Recurrent Orolabial Infection
Marie Studahl, Paola Cinque, Tomas Bergström in Herpes Simplex Viruses, 2017
Patients with herpetic gingivostomatitis present with fever, fetor oris, irritability and painful oral vesicular lesions on the gingival and bucal mucosa and on the tongue and hard palate. The vesicles rapidly rupture to become shallow ulcers and persist for a mean of 12 days (range 7–18 days) (26). The lesions are located only on the oral mucosa and tongue in approximately a quarter of the children; and on the gums in about three-fourth of cases (Fig. 1A, B). The gums are usually edematous and frequently bleed on contact. Extraoral lesions around the mouth (lips, cheeks, and chin) are found in approximately two-thirds of affected children at day four (26). Whitlows are seen in children that auto-inoculate their fingers.
Skin infections
Rashmi Sarkar, Anupam Das, Sumit Sethi in Concise Dermatology, 2021
Herpetic gingivostomatitis: Commonly, the lesions occur around the mouth or on the lip. They start as grouped, tender and/or painful papules or papulovesicles (Figure 3.20) and then coalesce to form a crusted erosion. The sequence takes about 7–14 days from initial discomfort to the final pink macule, marking where lesions have been. The initial infection may be quite unpleasant, with severe stomatitis, systemic upset and pyrexia. Resolution takes place in about 10 days. Reactivation of the herpes infection occurs in some cases, at varying intervals. Up to 20% of the population develops recurrent ‘cold sores’, so named because the disorder is often precipitated by minor pyrexial episodes.
Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study
Published in Journal of Oral Microbiology, 2021
Hee Sam Na, Suhkmann Kim, Seonghye Kim, Yeuni Yu, Si Yeong Kim, Hyun-Joo Kim, Ju Youn Lee, Jae-Hyung Lee, Jin Chung
A total of 112 subjects was recruited in the current study. These included 79 patients with PT and 33 subjects defined as healthy. The subjects were recruited at the Department of Periodontics of Pusan National University Dental Hospital, Yangsan, South Korea. In general, we enrolled individuals who were not pregnant or breastfeeding, had no systemic diseases that may affect the periodontal status, and had not received antibiotics in the last 6 months or undergone periodontal therapy (scaling and root planning) in the last 3 months. Exclusion criteria included the use of anti-inflammatory drugs, acute infection (e.g. herpetic gingivostomatitis), chronic mucosal lesion (e.g. pemphigus and pemphigoid) of the oral cavity, and a current status of smoking.