Rubella Virus Infections
Sunit K. Singh, Daniel Růžek in Neuroviral Infections, 2013
The cell-mediated immune response is also required to control infection and appears to persist for life. A mixed Thl/Th2 response is seen with serum interferon 7 during acute rubella. An increase in serum interleukin 10 (IL-10) levels has been detected during the first 4 days of illness. Lymphoproliferative responses develop a few days after onset of rash and persist at low levels for many years; the strongest responses are against the El protein. MHC class II restricted CD4+ T helper and CD8+ cytotoxic T lymphocytes can be detected shortly after the antibody response and several antigenic domains recognized by these cells have been identified within the El, E2, and C proteins (reviewed by WHO 2008).
Endotoxin Tolerance
Helmut Brade, Steven M. Opal, Stefanie N. Vogel, David C. Morrison in Endotoxin in Health and Disease, 2020
Interleukin-10 possesses considerable anti-inflammatory properties. It is of interest here that in vitro desensitization of monomac 6 cells resulted in increased production of IL-10 (47). IL-10 has been implicated in the process of in vitro desensitization since antibodies against IL-10 prevented the downregulation of TNF synthesis in cultured human monocytes by preincubation with LPS (46). On the other hand, the same authors reported that LPS desensitization of human monocytes resulted in impaired IL-10 formation of the cells when restimulated with LPS (46).
Immune Modulation In Sepsis
Thomas F. Kresina in Immune Modulating Agents, 2020
Interleukin 10 Interleukin 10 (IL-10) is an 18-kDa cytokine produced by a variety of cells, including T cells, B cells, monocytes, and macrophages [104], This cytokine, originally identified as “cytokine synthesis inhibitory factor,” inhibits the synthesis and gene expression of IL-1, TNF, IL-6, IL-8, and colony stimulating factors [105,106]. It has been detected in the plasma of patients with sepsis and after the administration of lipopolysaccharide to animals [107–110].
Nutritional Status of Allogeneic Hematopoietic Stem Cell Transplant Recipients and Post-transplant Outcomes
Published in Nutrition and Cancer, 2023
Stephanie Szovati, Caroline F. Morrison, Sarah C. Couch
Interleukin-10 is an anti-inflammatory cytokine that suppresses inflammatory processes in mature immune cells (32). Higher spontaneous interleukin-10 production in transplant patients is associated with fewer transplant related complications (33,34). Holler et al. found that patients with increased interleukin-10 at the time of admission had uneventful transplant courses and suggested a protective role of interleukin-10 (35). In the current study there was a trend for higher interleukin-10 levels post-transplant compared to pre-transplant, which suggests that on average, participants were moving into the phase of inflammation resolution and recovery. Additionally, the association between greater dietary quality of participants pre-transplant and higher IL-10 suggests the importance of optimizing patients’ nutritional status before transplant to promote synthesis of anti-inflammatory cytokines, such as IL-10, that aid in recovery.
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
Published in OncoImmunology, 2018
Alexandra Thomas, Eric D. Routh, Ashok Pullikuth, Guangxu Jin, Jing Su, Jeff W. Chou, Katherine A. Hoadley, Cristin Print, Nick Knowlton, Michael A. Black, Sandra Demaria, Ena Wang, Davide Bedognetti, Wendell D. Jones, Gaurav A. Mehta, Michael L. Gatza, Charles M. Perou, David B. Page, Pierre Triozzi, Lance D. Miller
Intriguingly, we identified significant and reproducible copy number gains in PID tumors involving genes on chromosome 1q associated with immune regulation. While amplification events at the gene-dense 1q locus occur in 50% or more of breast tumors,40 “driver” genes with immune regulatory functions have not been proposed. In our analysis, amplified immune genes were identified by the significant enrichment of immune-related ontology terms. Interleukin-10 (encoded by the IL10 gene) is an immunosuppressive cytokine known to inhibit tumor-specific type 1 immune responses.41 Fas ligand (FASLG) promotes activation-induced cell death (AICD) of activated T and B cells42 and is believed to confer immune privilege to tumors by inducing apoptosis in tumor infiltrating lymphocytes.43 Serpin Family C Member 1 (SERPINC1), also known as Antithrombin III, is a known inhibitor of T cell-derived Granzyme A.44,45 The reproducible PID-enriched amplification of these genes suggests the possibility that amplification of one or more of these genes, alone or in combination, may play a functional role in immune escape that contributes to the immunologically cold phenotype of the PID immune subclass.
Interleukin-10 may have diagnostic value in identifying mild traumatic brain injury
Published in Brain Injury, 2020
Anti–inflammatory interleukin-10 has recently been a major issue for research (8). The presence of interleukin-10 in the brain increases in the pathologic conditions of the brain, such as brain trauma and stroke, in order to maintain the survival of neural and glial cells and weaken the inflammatory responses (7). However, their application to mTBI is uncertain (5). In this regard, limited studies examined the diagnostic value of this interleukin in detecting brain lesions following mTBI. Recently, Lagerstedt et al. (2018) measured various inflammatory biomarkers (including 92 inflammatory biomarkers) in patients with mTBI and compared those values with brain CT scan results. The results showed that interleukin-10 might be a useful diagnostic tool to differentiate patients with positive and negative CT scan findings for brain lesions. However, performing more confirmatory investigations was suggested by authors (9).
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