Streptococcus pyogenes
Peter M. Lydyard, Michael F. Cole, John Holton, William L. Irving, Nino Porakishvili, Pradhib Venkatesan, Katherine N. Ward in Case Studies in Infectious Disease, 2010
Systemic causes of glomerular nephritis: Wegener granulomatosis.Hypersensitivity vasculitis.Cryoglobulinemia.Systemic lupus erythematosus.Polyarteritis nodosa.Henoch-Schönlein purpura.Goodpasture syndrome.Renal diseases.Membranoproliferative glomerulonephritis.
Genitourinary tract
Brian J Pollard, Gareth Kitchen in Handbook of Clinical Anaesthesia, 2017
‘Goodpasture syndrome’ originally described the entity of pulmonary haemorrhage and glomerulonephritis. Goodpasture disease is glomerulonephritis with pulmonary haemorrhage and the presence of circulating antiglomerular basement membrane (anti-GBM) antibodies. It therefore includes those diseases which are anti-GBM antibody negative as well as positive, such as:
Therapeutic apheresis in kidney diseases: an updated review
Published in Renal Failure, 2022
Yi-Yuan Chen, Xin Sun, Wei Huang, Fang-Fang He, Chun Zhang
Anti-glomerular basement membrane (anti-GBM) glomerulonephritis is a rare but potentially life-threatening autoimmune disease characterized by rapidly progressive glomerulonephritis (RPGN) with or without diffuse alveolar hemorrhage (DAH). The occurrence of both manifestations is known as Goodpasture syndrome, which has a high mortality rate [32]. Anti-GBM disease is mediated by circulatory anti-GBM antibodies targeting an epitope on the non-collagenous domain of the α3 chain of collagen type IV, which activating the complement cascade, results in tissue injury [33]. Antineutrophil cytoplasm antibodies (ANCA) can also be detected in 25% of patients [34]. The titers of these antibodies are associated with disease severity. Because the antibody is pathogenic, clearance of these antibodies is the most effective treatment.
Electron microscopy in renal pathology: overall applications and guidelines for tissue, collection, preparation, and stains
Published in Ultrastructural Pathology, 2021
David N. Howell, Guillermo A. Herrera
When confronted with a truly limited specimen, it is sometimes useful to consider the differential diagnosis being entertained by the clinicians. If a strong clinical suspicion for Goodpasture syndrome exists, for instance, it might be prudent to allocate a disproportionate amount of the tissue for IF. On the other hand, if the differential diagnosis includes IgA nephropathy vs. thin basement membrane nephropathy, obtaining optimal tissue for EM is crucial. It should be remembered that both IF and EM studies typically also yield slides for standard evaluation by LM, in the form of hematoxylin-and-eosin stained frozen sections and toluidine-blue-stained semithin survey sections, respectively.
Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease – a fifteen year single center experience
Published in Renal Failure, 2021
Zafirah Zahir, Asif Sadiq Wani, Narayan Prasad, Manoj Jain
Pulmonary renal syndrome due to involvement of both kidneys and lungs was found in 29.1% of total anti-GBM cases in our study. The incidence of pulmonary involvement in anti-GBM disease varies widely in literature ranging from as low as 23% [19] in few studies to as high as 63% in others [22]. Previously the literature reported incidence was between 40–60% [15]. However, recent reports have shown a less incidence of pulmonary-renal syndrome, in only 20–40% of patients [23]. In addition its incidence is further lower in elderly patients (>65 years) as compared to younger cohort [24]. Although pulmonary-renal picture is usually seen in young males and elderly females but in our study most of the patients were males (57.1%) with a mean age of 47 years. When compared to renal limited disease, patients presenting with pulmonary-renal syndrome had a higher frequency of associated hypertension and oliguria. On biopsy these patients had a higher percentage of crescents, increased interstitial inflammation and glomerulosclerosis as compared to the renal limited disease. They also had higher mean anti-GBM titers in their serum and increased rates of dialysis dependency at presentation. These findings suggest that the pulmonary involvement is a sign of severe disease. We could not find such comparisons in the previously described studies. Hirayama K [19] showed that the mean serum creatinine, blood leukocytosis, degree of anemia and urinary protein were higher in Goodpasture syndrome as compared to renal limited disease. We did not replicate such results other than serum creatinine, which was higher in renal-pulmonary involvement. In one of the largest single cohort study from China, patients with renal-pulmonary syndrome had significantly lower hemoglobin levels than renal limited disease. There was, however, no difference in their degree of hypertension, oliguria or serum creatinine levels [17].
Related Knowledge Centers
- Basement Membrane
- Immunosuppressive Drug
- Kidney Failure
- Corticosteroid
- Plasmapheresis
- Autoimmune Disease
- Glomerulonephritis
- Rare Disease
- Collagen, Type Iv, Alpha 3
- Cyclophosphamide