Anaemia
Sukhpreet Dubb, Neeral Patel, Nishma Manek, Dhruv Panchal, Shams Shamoon in Single Best Answers and EMQs in Clinical Pathology, 2013
For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all. 1 A 35-year-old man presents to his GP with a 1-month history of increased tiredness. The patient also admits to diarrhoea and minor abdominal pain during this period. His blood tests reveal the following: Hb 9.5 (13-18 g/dL) MCV 64 (76-96 fL) Fe 12.2 (14-31 µmol/L) TIBC 74 (45-66 µmol/L) Ferritin 9.2 (12-200 µg/L) Hb (haemoglobin); MCV (mean cell volume); Fe (iron); TIBC (total iron-binding capacity) 2 A 56-year-old vagrant man presents to the accident and emergency department with weakness in his legs. The patient has a history of poorly controlled Crohn’s disease. His blood tests demonstrate Hb 9.4 (13-18 g/dL) and MCV 121 (76-96 fL). A blood film reveals the presence of hypersegmented neutrophils.
Iron, Associated Proteins, and Vitamins
G.O. Evans in Animal Hematotoxicology, 2009
Iron-containing proteins play major roles as catalysts in oxidative processes (termed oxidative stress) that can affect DNA, lipids, and proteins, and where oxidation of these cellular components causes injury to the tissues. In chronic malignancies or chronic inammatory disorders, tissue macrophages can be activated and bind with apotransferrin, which consequentially reduces the available plasma total iron-binding capacity and produces an iron deciency anemia. Iron deciency is the most common cause of anemias, and these iron-deciency anemias often develop slowly. There are several drugs that have been associated with anemias caused by deciencies of iron and its associated vitamins. There now is sufcient evidence together with an improved knowledge of the role of erythryopoietin and the availability of new measurements on some automated hematology analyzers (see “Potential Markers” section) to suggest this area of erythrocytic metabolism requires wider investigation, and therefore a separate chapter has been devoted to the topic.
Does high maternal first trimester iron status have an effect on the 50 g oral glucose test?
Published in Journal of Obstetrics and Gynaecology, 2012
A. Ö. Yeniel, A. M. Ergenoglu, C. Y. Sanhal, C. Sahin, M. Ulukus, K. Oztekin
We aimed to test the hypothesis that 1st trimester high body iron status is associated with a high positive 50 g oral glucose tolerance test. In this study, 29 pregnant women with positive 50 g oral glucose tolerance test were compared with 94 negative 50 g OGTT patients as the control group in terms of 1st trimester iron status. Both groups had similar age, weight, height, body mass index and also median gravidity and parity values. Our results showed that there were no differences between groups in mean haemoglobin, haematocrit, serum iron, serum ferritin, total iron binding capacity and transferrin. Since it seems that free radicals have much influence on oxidative stress and glucose metabolism, prospective, randomised clinical trials should be designed to demonstrate the possible relation between maternal iron status and glucose intolerance.
Association of Malnutrition Inflammation Score With Anthropometric Parameters, Depression, and Quality of Life in Hemodialysis Patients
Published in Journal of the American College of Nutrition, 2019
Feray Gencer, Hilal Yıldıran, Yasemin Erten
Objective: Hemodialysis patients may be at risk for malnutrition due to catabolic effects caused by dialysis, loss of amino acids, inadequate nutrient intake, acidosis, and inflammation. Malnutrition may have negative effects on quality of life, mortality, and disease prognosis. This study was conducted to determine the relationship between anthropometric parameters, depression, and quality of life with Malnutrition Inflammation Score (MIS) on 55 patients aged between 18 and 65 years (36 males and 19 females) who have dialysis treatment for 3 days per week for at least 3 months due to end-stage renal disease. Methods: Patients were evaluated with MIS, Subjective Global Assessment (SGA), Beck Depression Inventory (BDI), and Satisfaction with Life Scale (SWLS). In addition, anthropometric (body weight, height, mid-upper arm circumference [MUAC]) and body composition measurements of patients were taken, body mass index (BMI) values were calculated, and biochemical parameters (albumin, C-reactive protein [CRP], and total iron binding capacity [TIBC]) were analyzed. Results: At the end of the study, 14.5% of the patients according to SGA, were classified as malnourished. There was a statistically significant positive correlation of BDI, duration of dialysis, and CRP with MIS. However, MIS had a statistically significant negative correlation with SWLS, body weight, and MUAC (p
Serum Iron, Total Iron-Binding Capacity of Serum, and Serum Copper in Normals
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 1953
The results are reported of determinations of serum iron, the total iron-binding capacity of serum, and serum copper in normals, and the methods employed are described. The serum iron concentration proved to be highest in males, the total iron-binding capacity alike in males and females. No relationship was observed between the serum iron and serum copper values by simultaneous determination, and no definite relation can be seen between the values of serum iron and total iron-binding capacity of serum.
Related Knowledge Centers
- Anemia
- Iron Deficiency
- Iron Deficiency Anemia
- Transferrin Saturation
- Transferrin
- Phlebotomy
- Serum Iron