Plants Species with Anticancer Activity
Spyridon E. Kintzios, Maria G. Barberaki, Evangelia A. Flampouri in Plants That Fight Cancer, 2019
The successful clinical introduction was substantially delayed, largely due to problems with insolubility and instability, particularly of the ring E lactone. Late diarrhea (generally occurring more than 24 hours after administration of Camptosar®) can be life threatening since it may be prolonged and may lead to dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated promptly with loperamide. Patients with diarrhea should be carefully monitored and given fluid and electrolyte rement if they become dehydrated or antibiotic therapy if they develop ileus, fever, or severe neutropenia. The most common side effects with Hycamtin® (topotecan hydrochloride) are infections. Blood disorders are also common, where reduced levels of certain blood cells may cause anemia, reduced resistance to infections, and increased bruising or bleeding.
Translating the Medical Record
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss in Understanding Medical Terms, 2020
Blood studies assess disorders of cell production (hematopoiesis), synthesis, and function. Examination of the blood and bone marrow are the primary means of determining blood disorders. Venipuncture is used to procure larger samples of blood for testing. Bone marrow specimens are obtained through needle biopsy or aspiration. A hemogram includes platelet count, white blood cell count (WBC), red blood cell count (RBC), hematocrit (Hct), and indices. A complete blood count (CBC) includes a hemogram plus differential count.
Transforming social divisions
Kate Reed in Gender and Genetics, 2012
As argued throughout this book inherited blood disorders are more likely to occur in particular populations. Statistics show significant variation in positive carrier rates between ethnic groups with 1.85 per 1000 in those babies recorded as white British compared to 145 per 1000 African babies (Streetly et al. 2010). Due to the low risk of white British populations being identified as carriers of the sickle or thalassaemia trait, research has tended not to focus on the impact of inherited blood disorders on white British women and men. However, white people can be and are carriers of sickle and thalassaemia trait (there was one white respondent in this study who was a thalassaemia carrier). However, most white respondents within this study tended to assume that their ethnicity placed them as low risk of being carriers and therefore distanced themselves from this screening. This can be seen in the account below from Joanne, who was in the second trimester of pregnancy: We were asked for consent about whether we wanted to have all these things and I am quite. I think I am quite well informed about quite a lot of things anyway about biology and screening. … I didn’t really feel like I needed to ask questions but I think my partner did. Things like the thalassaemia I know that we have a very very slim chance of having that because it tends not to be found in white people.(Joanne, 35, Nurse)
Perspectives on Hemoglobinopathies from Egypt: Challenges and Burden to the Healthcare System
Published in Hemoglobin, 2019
Hereditary blood disorders are chronic genetic disorders where the affected person suffers ill health throughout his/her life. They place a strong socioeconomic and emotional burden on the patients and their families. In Egypt, thalassemia is the most common hereditary chronic hemolytic anemia with an estimated carrier rate between 5.3 and 9.0%, and more than 1000 patients are born every year. The quality of life (QoL) of patients, as well as their performance, is markedly affected as well as their families', and ultimately, their productivity and society in general. Aside from affecting the QoL, the disease creates a social and financial burden for the patient, family, and government, with an average estimated financial burden of 10 million $/year. Even in carefully managed patients, complications may develop due to iron overload, blood-related viral transmission and organ failure. The establishment of reliable, cost-effective national screening programs, and consequent prevention programs, fall on the Egyptian Ministry of Health to combat these burdens. Several efforts are continuously exerted including defining β-thalassemia (β-thal) haplotype mapping and prevalent mutations, correlating them with phenotypic outcome as well as evaluating intra-familial heterogeneity. Parental education and alternate therapies to decrease blood transfusion frequency for a better QoL is mandatory. Ultimately, providing better counseling and to set a challenge to continuing research for better screening and management.
Cost-effectiveness of baloxavir marboxil compared with laninamivir for the treatment of influenza in patients at high risk for complications in Japan
Published in Current Medical Research and Opinion, 2021
Mariia Dronova, Hidetoshi Ikeoka, Naoya Itsumura, Nobuo Hirotsu, Amir Ansaripour, Samuel Aballéa, Yoshie Onishi, Mark Hill, Ataru Igarashi
The following list of HRC was considered in line with the Centers for Disease Control and Prevention’s definition and phase III clinical trial of baloxavir3,8:Asthma or chronic lung disease.Endocrine disorders.Compromised immune system.Neurological and neurodevelopmental disorders.Heart disease (excluding hypertension).Blood disorders.Metabolic disorders.Morbid obesity.Women within 2 weeks postpartum – for patients aged <65 years only.Residents of long-term care facilities – for patients aged ≥65 years only.
Trends, predictors, and outcomes of major bleeding after transcatheter aortic valve implantation, from national inpatient sample (2011–2018)
Published in Expert Review of Cardiovascular Therapy, 2021
Salman Zahid, Waqas Ullah, Muhammad Usman Khan, Sakina Abbas, Mian Tanveer Ud Din, Muhammad Faisal Uddin, Arslan Inayat, Aamer Ubaid, Fnu Salman, Samarthkumar Thakkar, Amr Salama, Muhammad Zia Khan
The higher bleeding complications with baseline hematological problems related to platelets and coagulation factors were identified in our study. These findings are reinforced by a well described association of major bleeding events with blood disorders in previous literature [9]. In addition to this, patients with ESRD have a propensity to bleed due to the inherent platelet dysfunction and thus are associated with high mortality [10,[11]. Similarly, Liver disease patients have increased tendency to bleed due to associated coagulopathy [12]. These findings were reinforced in a previous meta-analysis consisting of 1652 patients where chronic liver disease patients had higher incidence of mortality, bleeding complications and need for blood transfusions [13]. This association is further exacerbated by anti-platelet and anticoagulant drug use [14,[15].
Related Knowledge Centers
- Anemia
- Haematopoiesis
- Hemoglobinopathy
- Methemoglobinemia
- Blood
- Hemoglobin
- Red Blood Cell
- HIV
- Sickle Cell Disease
- Thalassemia