Responding to the Community’s Need for Therapeutic Hemapheresis
James L. MacPherson, Duke O. Kasprisin in Therapeutic Hemapheresis, 2019
In the early stages of hemapheresis, support with granulocytes and/or HLA-matched platelets was the principal focus for application of cell separation technology. Usually, hospital blood banks or community blood centers operated the equipment as a logical extension of their transfusion services. In addition, many hospitals with active oncology units operated “cell support units”. The first calls to provide therapeutic services usually came from the hematology services to treat hyperviscosity syndrome or leukemics in high cell proliferative stages. When experimentation grew in areas such as neurology, nephrology, and dermatology, consideration for who and what could more effectively provide the service, or decisions based upon who would control patient protocols, led to a plethora of various providers of therapeutic hemapheresis services.
Major haemorrhage
Daniel Cottle, Shondipon Laha, Peter Nightingale in Anaesthetics for Junior Doctors and Allied Professionals, 2018
Once alerted, blood bank can prepare suitable blood products depending on the urgency of the situation. Blood products should be ordered as early as possible, since fresh frozen plasma (FFP) and cryoprecipitate take 30 minutes to defrost.Group-specific blood can usually be issued within 15 minutes of receiving a sample, and this should be requested if possible to preserve the scarce O-negative supply.Fully cross-matched blood takes up to 45 minutes.If blood is required immediately then group O-negative should be requested. A small supply of O-negative packed red cells is usually maintained in emergency care areas for this use, including emergency theatre, obstetric theatre and the emergency department.
Drug-induced and iatrogenic interstitial lung disease
Muhunthan Thillai, David R Moller, Keith C Meyer in Clinical Handbook of Interstitial Lung Disease, 2017
With blood transfusion, notification to the office for blood transfusion safety or blood bank is mandatory to possibly identify the antibody-bearing donor in the donor pool, usually a multiparous female, who should be removed from the pool thus preventing the development of further cases (72,74). Severe DI pulmonary oedema can be accompanied by some degree of alveolar haemorrhage (75). There may be a continuum from non-cardiac permeability pulmonary oedema to DAD with some patients in the low range of severity having mild transient and reversible pulmonary infiltrates while others develop full-blown pulmonary oedema and yet others evolve to DAD and ARDS (6). Other drug-induced pulmonary oedema includes acute drug-induced left ventricular failure following therapy with anthracycline, trastuzumab or novel antineoplastic drugs (see sections II and XII in [1]), and pulmonary oedema of the acute vasoconstrictive type following the administration of the vasopressors epinephrine or derivatives (1).
Thalassemia in the Philippines
Published in Hemoglobin, 2022
Ernesto d’J. Yuson, Maria Liza T. Naranjo
Until the mid-1990s, commercial blood banks were mainly utilized to provide blood to needy recipients. When the Republic Act (RA) #7719 National Blood Services Act of 1994 was mandated into law in 1997, the impetus for strictly non remunerated blood from voluntary donors was gradually established and accepted. The Philippine Blood Center (PBC) is a national blood source for the country’s hospitals. The Philippine Red Cross, as an international and private entity, emerged as an additional source of blood. The initial goal of the PBC was to target 1.0% of the total population to become voluntary blood donors, which was achieved during the second decade of the 21st century (2014). A concentrated effort to assert the importance of voluntary blood donation is gaining momentum, especially in communities that still depend highly on blood donor replacement strategies.
Monoclonal B-cell lymphocytosis in blood donors in Turkey
Published in Hematology, 2018
Münci Yağcı, Zeynep Arzu Yegin, İdil Yenicesu, Elif Suyanı, Bahar Uncu Ulu, Kamil İnci, Zeynep Çetin, Zeynep Yılmaz, Nevruz Kurşunoğlu, Zübeyde Nur Özkurt
A total of 999 volunteers [median age 34 (18–78) years; male/female: 705/294] were randomly selected among the blood donors who applied to Gazi University Blood Bank between 2010 and 2012. The diagnosis of MBL was identified based on the International Familial CLL Consortium Report which was recently confirmed by WHO criteria: (i) detection of a disease-specific immunophenotype or an overall kappa (κ)/lambda (λ) ratio >3:1 or κ/λ < 0.3:1, (ii) stable monoclonal B-cell population over a 3-month period (iii) absence of lymphadenopathy, organomegaly, autoimmune or infectious diseases and B lymphocyte counts <5 × 109/l [11,13,17]. Nevertheless, in the current study, blood donors were tested for MBL only before donation and the stability of MBL in positive donors was not confirmed over a 3-month period.
Association of MIR-499a expression and seed region variant (rs3746444) with cardiovascular disease in Egyptian patients
Published in Acta Cardiologica, 2018
Manal S. Fawzy, Eman A. Toraih, Elham O. Hamed, Mohammad H. Hussein, Hussein M. Ismail
Cardiovascular risk factors were recorded as described previously [16,20,21]. Unrelated healthy blood donors attending our hospital’s blood bank were included as controls. They had no past history of cardiovascular problems and had a normal resting ECG. Cui and Zao [22] highlighted the importance of selecting the proper control group in all investigations aimed at identifying or testing a diagnostic marker and confirmed that using healthy people only as a control group might artificially increase the specificity of the diagnostic tests. Indeed, in clinical practice, patients often suffer from various other diseases, some of which might impact upon the biomarker under investigation. Hence, we included in the current study a non-MI group of essential hypertensive patients (n = 76). The study was conducted in accordance with the guidelines in the Declaration of Helsinki and approved by the Medical Research Ethics Committee of Faculty of Medicine, Suez Canal University (approval no. 2715). Written informed consents were obtained from participants before taking part.
Related Knowledge Centers
- Blood Transfusion
- Clinical Pathology
- Coagulation
- Fresh Frozen Plasma
- Plasmapheresis
- Blood
- Blood Donation
- Blood Compatibility Testing
- Whole Blood
- Platelet Transfusion