Bile Duct Cancer
Dongyou Liu in Tumors and Cancers, 2017
The intrahepatic bile ducts are small ducts located within the liver. These small ducts merge to form the left and right hepatic ducts, which exit the liver at the hilum and then join together to form the common hepatic duct. The extrahepatic bile ducts include part of the right and left hepatic ducts outside the liver, the common hepatic duct, and the common bile duct and may be further divided into the perihilar bile duct (or the proximal extrahepatic bile duct, which starts from the perihilar area and ends at the point where the cystic duct joins the common hepatic duct) and the distal extrahepatic bile duct (located between the junction where the cystic duct joins the common hepatic duct and the ampulla of Vater, which is a channel formed by the common bile duct joining the pancreatic duct). The cystic duct connects the common bile duct with the gallbladder.
Diseases of the Hepatobiliary Tree and Pancreas Associated with Fever
Benedict Isaac, Serge Kernbaum, Michael Burke in Unexplained Fever, 2019
Clonorchiasis — This is caused by the Oriental liver fluke, Clonorchis sinensis, is endemic in the Far East and may present with a febrile course. The most common complication is recurrent pyogenic cholangitis or Oriental cholangiohepatitis, which is characterized by repeated bouts of abdominal pain and fever, associated with jaundice, hepatomegaly, and frequently, eosinophilia. Intravenous cholangiography may demonstrate dilated intrahepatic bile ducts with partial filling defects which represent flukes. Tiny opercular ova observed in the feces will confirm the diagnosis. The complications, pancreatitis and cholangiocarcinoma, may sometimes evolve with a febrile course.
Neonatal jaundice and liver disease
Janet M Rennie, Giles S Kendall in A Manual of Neonatal Intensive Care, 2013
Four main pathological entities account for this syndrome:Hepatocellular disease: hepatitis.Inflammation and bile duct damage.Disorders of the main intrahepatic bile ducts.Disorders of the extrahepatic bile ducts.
The impact of a multi-hospital network on the inequality in odds of receiving resection or ablation for synchronous colorectal liver metastases
Published in Acta Oncologica, 2023
Roos G. F. M. van der Ven, Daan Westra, Felice N. van Erning, Ignace H. de Hingh, Steven W. M. Olde Damink, Agnes Paulus, Wouter K. G. Leclercq, Marcel den Dulk
Adult patients (≥18 years) with stage-IV CRC with SCLM without extrahepatic metastases diagnosed in the Netherlands between 2009 and 2020 were included. Primary tumor localizations included were colon (C18), rectosigmoid transition (C19), and rectum (C20), with the presence of synchronous liver metastases (C22.0), defined as metastases detected before initial treatment was started and/or during surgical exploration. Metastases of the intrahepatic bile ducts (C22.1) were excluded due to their rarity. Patients were also excluded if the primary tumor concerned a neuroendocrine tumor. Only synchronous metastases are included due to data availability. One hospital performed resection and ablation treatment up to 2017 but stopped doing so from 2017 forward. Patients diagnosed in this hospital were assigned to the ‘expert’ group if diagnosed before 2017, and to the ‘nonexpert’ group if diagnosed from 2017 forward.
Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia
Published in Growth Factors, 2019
Omid Madadi-Sanjani, Joachim F. Kuebler, Stephanie Dippel, Anna Gigina, Christine S. Falk, Gertrud Vieten, Claus Petersen, Christian Klemann
Biliary atresia (BA) is a rare, progressive fibro-obliterative cholangiopathy in infants (Verkade et al. 2016). The progressive destruction of extrahepatic and intrahepatic bile ducts results in liver cirrhosis and is the leading indication for pediatric liver transplantation (LTX) (Petersen and Davenport 2013; Asai, Miethke, and Bezerra 2015). Without intervention, the disease is fatal within the first 2 years of life. Kasai-portoenterostomy (KPE) can temporarily restore biliary drainage, but in more than 50% of children, continuous deterioration results in re-occurrence of jaundice and in 70–80% a LTX becomes necessary (Davenport et al. 2011; de Vries et al. 2012; Chardot et al. 2013). The mortality of pediatric patients on LTX waiting lists (∼20%) imposes a clinical problem and therefore early predictors for rapid liver failure (RLF) necessitating LTX are desirable (Tessier et al. 2014). In addition, some authors have recently discussed primary LTX in BA to be beneficial (Superina 2017). Therefore, it would be ideal to identify biomarkers that predict the further course of disease in BA and may identify infants at risk who most likely not benefit from KPE and thus may be considered for primary LTX.
IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease
Published in Modern Rheumatology, 2018
Koichi Inoue, Takehiko Okubo, Takashi Kato, Kazuo Shimamura, Teruji Sugita, Mitsuhiro Kubota, Kohji Kanaya, Daisuke Yamachika, Makoto Sato, Dai Inoue, Kenichi Harada, Mitsuhiro Kawano
The findings of endoscopic retrograde cholangiography in IgG4-SC are classified into 4 types [19], and the findings in this case were compatible with type 4, which is characterized by focal stenosis of the hilar bile duct. Retrospectively, our case probably had IgG4-SC since 1999, as this disease concept was not proposed then, he was treated with ursodeoxycholic acid under the diagnosis of SC of unknown etiology. Although obstructive jaundice did not develop despite the non-administration of corticosteroid for a long time, the dilatation of the intrahepatic bile ducts led to liver abscess. Saito et al. also reported a case with IgG4-SC accompanied by severe suppurative inflammation before starting steroid therapy [20]. Hence, early steroid treatment might have prevented the development of liver abscess in our case.
Related Knowledge Centers
- Canals of Hering
- Common Hepatic Duct
- Exocrine Gland
- Liver
- Bile
- Interlobular Bile Ducts
- Canals of Hering
- Perisinusoidal Space