Esophageal Cancer
Pat Price, Karol Sikora in Treatment of Cancer, 2020
Other known risk factors for esophageal SCC include structural abnormalities such as achalasia, which increases the risk up to 16-fold16,17; caustic strictures are also associated with SCC,18 and Plummer–Vinson syndrome is a condition associated with esophageal web formation in the post cricoid region and with an increased risk of SCC.19 Lastly, Tylosis palmaris (type A) is an autosomal dominant condition now known to be due to mutations in RHBDF2 located on chromosome 17q25.1, and this condition leads to a very high lifetime risk of developing the disease (95% by the age of 70).20
Nonhematological Manifestations of Iron Deficiency
Bo Lönnerdal in Iron Metabolism in Infants, 2020
Dysphagia in iron deficiency anemia is believed to be secondary to obstruction caused by a web of tissues with a predilection for the postcricoid region of the hypopharynx. Webs can also occur in the esophagus; the specificity of web formation for iron deficiency has been questioned, however.50,51 Moreover, in an iron-deficient individual, the esophageal web, which is a precancerous lesion, does not respond to iron therapy although dysphagia was frequently relieved.52 It is also important to note that dysphagia is reported to be rare in parts of Africa in which iron deficiency is common.53
Esophageal foreign bodies in adults: systematic review of the literature
Published in Scandinavian Journal of Gastroenterology, 2018
Alberto Aiolfi, Davide Ferrari, Carlo Galdino Riva, Francesco Toti, Gianluca Bonitta, Luigi Bonavina
An underlying esophageal disorder was diagnosed in 25.7% of the patients. The most commonly associated disorders were stricture (33.9%), hiatus hernia (20.2%) and esophageal web or Schatzki ring (17.1%). Eosinophilic esophagitis was diagnosed at the time of presentation in 9.5% of patients. However, a population-based study showed that eosinophilic esophagitis can be the cause of food bolus impaction in up to 16% of patients; this data may still be underestimated because biopsies are not routinely taken in these patients [63]. In addition, the presence of an esophageal web may be part of the spectrum of eosinophilic esophagitis. Despite the removal of food bolus is successful in 98% of patients at first endoscopy, recurrence was most commonly observed in patients with eosinophilic esophagitis [63].
The Association between Meibomian Gland Atrophy and Corneal Subbasal Nerve Loss in Patients with Chronic Ocular Graft-versus-host Disease
Published in Current Eye Research, 2021
Ozlem Dikmetas, Sibel Kocabeyoglu, Mehmet Cem Mocan
This was a cross-sectional study conducted in a single tertiary referral academic center. The study was approved by the Institutional Review Board (IRB approval: GO 20/163 2020/04-34) and adhered to the tenets of the Declaration of Helsinki. The study cohort consisted of adult patients who had undergone allo-HSCT and were diagnosed as having DED in the presence of systemic GVHD. The diagnosis of systemic and ocular GVHD was made in accordance with the 2014 National Institutes of Health (NIH) consensus by the treating hematologist and ophthalmologist, respectively.24 At least one diagnostic clinical sign of GVHD (i.e. poikiloderma or esophageal web) or the presence of at least one distinctive manifestation (keratoconjunctivitis sicca) confirmed by biopsy or other relevant tests (i.e. Schirmer I test) in the same or another organ had to be present for the diagnosis of GVHD.25 Inclusion criteria included patients >18 years of age, presence of DED, and history of a stable systemic clinical course following allo-HSCT. Exclusion criteria included prior history of intraocular or corneal surgery and ocular trauma, preexisting DED prior to HSCT, previous history of contact lens wear, and co-existing corneal disease.
Related Knowledge Centers
- Bullous Pemphigoid
- Dysphagia
- Pulmonary Aspiration
- Epidermolysis Bullosa
- Esophagus
- Pain
- Swallowing
- Plummer–Vinson Syndrome
- Iron-Deficiency Anemia
- Pemphigus