Neurological Manifestations of Medical Disorders
John W. Scadding, Nicholas A. Losseff in Clinical Neurology, 2011
Pregnancy causes the pituitary gland to enlarge. Sheehan syndrome is a rare condition of pituitary infarction, usually caused by postpartum hemorrhage and systemic hypotension, or by the vascular demands of an enlarging pituitary gland exceeding the available vascular supply. Infarction may transform into haemorrhage. Infarction or haemorrhage can result in acute pituitary insufficiency and shock, hence the term pituitary apoplexy. Lymphocytic hypophysitis is thought to be of autoimmune origin and is usually self-limiting. Treatment with corticosteroids is indicated if there is visual impairment due to chiasmal compression.
Pregnancy and Sex-Related Deaths
John M. Wayne, Cynthia A. Schandl, S. Erin Presnell in Forensic Pathology Review, 2017
Answer E is correct. Sheehan syndrome is defined as pituitary necrosis with a degree of failure occurring in the setting of pregnancy and is more common when significant blood loss occurs around the time of delivery. The pituitary gland is at risk of necrosis from abrupt decrease in blood pressure more so in association with pregnancy since it is enlarged. Such necrosis may be an incidental finding at autopsy depending on the extent of necrosis or may be the cause of death from acute panhypopituitarism.
Amenorrhoea and oligomenorrhoea
David M. Luesley, Mark D. Kilby in Obstetrics & Gynaecology, 2016
Sheehan syndrome is a condition of hypopituitarism due to ischaemic necrosis of the pituitary after massive post-partum haemorrhage. The first hormones to be affected are the gonadotrophins and growth hormone followed by ACTH and finally TSH.
The autoimmune basis of hypopituitarism in traumatic brain injury: fiction or reality?
Published in British Journal of Neurosurgery, 2019
Viraat Harsh, Sukriti Jha, Hitesh Kumar, Anil Kumar
Injury due to secondary causes such as hypotension, hypoxia and anemia has also been described.3,4 For instance, Sheehan Syndrome, a classical cause of postpartum hypopituitarism results from obstetrical mishaps like hemorrhage and consequent hypotension.5 Genetic factors have also been implicated in the development of PTHP. The presence of Apoporotein E haplotype is believed to reduce the risk of developing pituitary dysfunction.6
Dilated cardiomyopathy and rhabdomyolysis caused by hypopituitarism: a challenging diagnosis
Published in Acta Cardiologica, 2020
Pauwelijn Verhoestraete, Marijn Carpentier, Jan Donck, Hans Vandekerckhove
Non-ischemic cardiomyopathy associated with anterior hypopituitarism can be attributed to TSH, cortisol and GH deficiencies. It is important to consider the possibility of these hormone deficiencies when diagnosing a patient with non-ischemic cardiomyopathy. In woman, one should always consider hypopituitarism secondary to Sheehan syndrome as an aetiology of cardiomyopathy, even though the symptoms can be very mild.
Related Knowledge Centers
- Bleeding
- Childbirth
- Hypovolemic Shock
- Lactation
- Menstruation
- Necrosis
- Pituitary Gland
- Hypothalamus
- Sella Turcica
- Hypopituitarism