Anti-Hyperglycemic Property Of Medicinal Plants
Amit Baran Sharangi, K. V. Peter in Medicinal Plants, 2023
Diabetes Mellitus or Diabetes is a metabolism malady resulting in under production or no production of insulin in our body due to which glucose metabolism in our body becomes faulty. Production of insulin occurs through the pancreatic gland in our body and responsible for glucose uptake and breakdown, thus in its absence glucose starts to build up in the body creating a metabolic disorder. Diabetes is epidemic in nature and highest prevalence of hyperglycemia has been reported among adults in North Africa and Middle East region, i.e., 10.9% whereas, highest number of adults has been diagnosed in the region of Western Pacific, i.e., 37.5% (Kharroubi and Darwish, 2015). It plays an important role as a contributor to ill health and premature death worldwide. In India, hyperglycemia was considered to be a disease of urban population as it was more common in cities due to lifestyle changes and gradual increase of junk and fast-food intake. Diabetes symptoms include increase thirst, frequent urination, fatigue, hunger, and blurred vision.
Solutions Using Machine Learning for Diabetes
Punit Gupta, Dinesh Kumar Saini, Rohit Verma in Healthcare Solutions Using Machine Learning and Informatics, 2023
Diabetes is of three types.Type1 diabetes. This happens when the human immune system mistakenly attacks and destroys the β-cells, causing permanent loss of insulin. Hence, there is no insulin production in the body.Type 2 diabetes. This occurs when tissue in the body cannot use insulin efficiently, or in medical terminology, “insulin resistance”. In this there are insufficient amounts of insulin production.Gestational diabetes. This occurs due to hormones blocking insulin production during pregnancy.Various risk factors affect diabetes [19], including self-behavior, diabetes management and monitoring, and medication. Self-behavior is generally a reflection of the individual’s way of dealing with diabetes in daily life, including lifestyle, smoking habit, excessive weight, family history, and blood sugar level (Figure 3.2). People with diabetes are usually given healthy lifestyle advice, including exercise and diet control. In other cases, medication is required.
Natural Products in the Treatment of Unremitting Wounds Secondary to Diabetes or Peripheral Vascular Disease
Namrita Lall in Medicinal Plants for Cosmetics, Health and Diseases, 2022
There remains a high economic cost of diabetes, which accounts for approximately 10% of all healthcare expenditure (International Diabetes Federation, 2015). People with diabetes will spend 2–5 times more on healthcare in their lifetime than people without diabetes (Tabish, 2007). One study projected the global cost of diabetes to be 1.31 trillion US dollars in 2015 alone (Bommer et al., 2017). In addition to the economic costs, there is a significant social cost to diabetes. Diabetes can lead to an extensive risk to a person’s overall health. Heart disease, stroke, blindness, kidney damage and nerve damage are common secondary complications of diabetes. Microvascular and macrovascular disease are common, with cardiovascular complications as a leading cause of mortality among people with diabetes (Zheng, Ley, and Hu, 2018). Diabetes and peripheral arterial disease (PAD) are closely linked since diabetes is a known risk factor for developing arteriosclerosis and PAD (Murabito, D’Agostino, Silbershatz, and Wilson, 1997).
Horticultural crops as natural therapeutic plants for the therapy of diabetes mellitus
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Balikis Oluwakemi Mustapha, Olufemi Temitope Ademoyegun, Rabiat Shola Ahmed
Diabetes mellitus is a long-term metabolic disorder that occurs as a result of the body’s inability to produce or use insulin and this affects human physical, social and psychological health. The pancreas produces insulin in the body which helps to convey blood sugar from the bloodstream to the cells which further breaks down and is used as fuel for normal body metabolism. The disease is typically attributed to lack of glucose homeostasis brought on by errors in insulin production or activity which in turn result in an improper metabolism of glucose and other sources of energy like protein and lipid. This is frequently accompanied by a loss of energy and body weight as well as significant alterations in lipid metabolism. Diabetes can cause serious side effects such as blindness, stroke, heart attack, liver malfunction, nerve damage and kidney failure if it is not treated properly [2]. They occur in two types, namely, Type 1 (also known as Juvenile type) which is insulin-dependent and hereditary. It is an autoimmune disease in which the immune system accidentally attacks the insulin-producing cells of the pancreas. This type is common in children and adolescents.
Feasibility study on the use of the modified Finnish Diabetes Risk Score in South African context: a case of home-based carers
Published in Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2023
TM Mothiba, MH Mphasha, TT Molepo, H Bastiaens, J Wens
The purpose of this study was to determine the feasibility of introducing the FINDRISC tool in South Africa. This was done through assessing competence or lack thereof of HBCs in using the FINDRISC questionnaire to assess the risk status of diabetes patients. Diabetes patients frequently receive care from HBCs, who also act as a liaison between local communities and medical facilities. The following aspects of this instrument were examined to determine whether it was being utilized competently or not: physical activity, diet, body mass index, waist circumference and the existence of illnesses. Diet and exercise are crucial aspects of diabetes care.28 Poor eating practices and insufficient physical exercise are linked to weight gain,29 which in turn causes obesity,30 and puts patients at higher risk of comorbid disorders and complications.. Comorbid diseases have been demonstrated to affect a patient’s capacity to prioritise and control their diabetes.31 Healthcare professionals in the community provide patient care and are a vital link between healthcare services and communities.
Phthalocyanine-based glucose-responsive nanocochleates for dynamic prevention of β-cell damage in diabetes
Published in Journal of Liposome Research, 2023
Sharayu Govardhane, Pravin Shende
Diabetes is a metabolic disorder caused by the rise in the blood glucose level and inability to maintain glucose homeostasis (hyperglycemia). World Health Organization (WHO 2021) data denoted that worldwide more than 422 million people are subjected to diabetes (WHO 2021). The most common symptom of diabetes is dyslipidemia, higher blood glucose level, blurry vision, fatigue, thirst, and weight loss. Diabetes condition generates free radicals transformed to free unpaired electrons which creates oxidation of cellular membrane. The oxidative stress in diabetes lowers the ability of antioxidant enzymes, decreases the concentrations of low molecular weight antioxidants in tissue, disturbs the redox shifts, and creates auto-oxidation of glucose (Pitocco et al.2013). The common limitations associated with the current therapy of insulin is hypoglycemia and insulin reaction or insulin resistance (Lamounier et al.2018). Other than insulin, drugs like metformin, sulfonylureas, α-Glucosidase inhibitors, etc. are susceptible to gastrointestinal side effects (diarrhea, abdominal pain, flatulence), weight gain, pancreatitis, and cardiovascular safety issues like atherosclerosis, high blood pressure, etc. (Davies et al.2022).
Related Knowledge Centers
- Blurred Vision
- Diabetic Nephropathy
- Diabetic Neuropathy
- Diabetic Retinopathy
- Endocrine Disease
- Hyperglycemia
- Pancreas
- Cardiovascular Disease
- Polyuria
- Insulin