Papules
Giuseppe Micali, Pompeo Donofrio, Maria Rita Nasca, Stefano Veraldi in Vulval Dermatologic Diagnosis, 2015
Etiology: The pathogenesis of the proliferative abnormality leading to sebaceous hyperplasia is not fully understood. It is considered to be a hamartoma rather than a true neoplasm. Hormonal factors and chronic inflammation from HPV infection, previous surgery or ultraviolet exposure have been inconclusively considered among the possible cofactors of both conditions.
Tumors of Cutaneous Appendages
Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman in Dermatopathology Primer of Cutaneous Tumors, 2015
Sebaceous hyperplasia: Has only one or two cell layers of germinative epitheliumRelatively normal and uniform sebaceous lobules
Diseases of Infancy and Childhood
Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang in Roxburgh's Common Skin Diseases, 2022
Sebaceous hyperplasia is a common and benign condition of the sebaceous glands. In neonates, it results from exposure to maternal hormones. These are multiple white-yellowish tiny papules that commonly occur around the nose and upper lips of full-term infants. Lesions gradually involute, which usually happens within the first few weeks of life.
Dermatological indications for the use of isotretinoin beyond acne
Published in Journal of Dermatological Treatment, 2018
Emily Forbat, Faisal R. Ali, Firas Al-Niaimi
A randomized comparative trial comparing alternate daily use of 10 mg isotretinoin versus topical anti-seborrheic treatment in moderate to severe seborrhea and seborrheic dermatitis (N = 45) over 6 months, demonstrated a significantly greater reduction in scalp sebum secretion (p = .004) in the isotretinoin arm after 3 months (47). Patients were not followed-up beyond 3 months and the dosage was not weight-dependent. Tagliolatto et al. treated 20 patients with sebaceous hyperplasia with isotretinoin (1 mg/kg per day) for 2 months; the average number of skin lesions decreased from 24 to 2 per patient (p < .05) (59). Isotretinoin is beneficial in sebaceous hyperplasia and sebaceous adenoma (7), cyclosporine-induced sebaceous hyperplasia in renal transplant (15,23), and diffuse familial sebaceous hyperplasia (14).
Investigation of laser pulsing parameters’ importance in Er:YAG laser skin ablation: a theoretical study conducted via newly developed thermo-mechanical ablation model
Published in International Journal of Hyperthermia, 2019
Hossam El-Khalil, Mousa Alzanina, Khaldon Lweesy, Aiman Alshare
Varying effects of pulsed laser parameters on tissue ablation and coagulation were observed by different researchers for different laser-tissue combinations. Pioneering work by Anderson and Parrish suggested the possibility of selectively targeting microstructures through employing shorter laser pulse durations than the thermal relaxation time, a concept they referred to as thermal confinement [15]. Careful tuning of laser pulse duration and fluence was shown to allow for selective blood vessel coagulation without rupture [16,17]. Depth of craters made in egg whites varied significantly with pulse duration and fluence [16–18]. Moreover, Walsh et al. observed significant increase in coagulation thickness when increasing pulse duration [19]. On the other hand, pulse duration effect on treatment efficacy of sebaceous hyperplasia was insignificant [17]. Also Ross et al. observed insignificant effect of pulse duration on thermal damage depth [20]. However, they found that ablation threshold increased with increasing pulse duration. Overall, the understanding of affecting mechanisms and importance of laser pulsing parameters in laser tissue ablation is inadequate [19–21].
An unusual presentation of eruptive syringomas on the neck
Published in Baylor University Medical Center Proceedings, 2021
Madeline R. Frizzell, Saadeddine S. Saad, Katherine H. Fiala
Adding to the diagnostic conundrum was the concurrent presence of juxtaclavicular beaded lines. This is a benign anatomical variant of sebaceous hyperplasia presenting as parallel lines of papules resembling strings of pearls usually localized in juxtaclavicular areas, but also commonly found at the nape of the neck, inguinal region, and axillae.5 While this entity is commonly reported in dark-skinned adults, there are minimal reports of fair-skinned and prepubescent children presenting with this variant of sebaceous hyperplasia. The etiology is unknown; however, hormonal influences, sun exposure, and links to corticosteroid treatment have been noted.5
Related Knowledge Centers
- Acne
- Hair Follicle
- Papule
- Sebaceous Adenoma
- Skin
- Sebaceous Gland
- H&E Stain
- Sebaceous Carcinoma
- Skin Condition