Principles of Clinical Diagnosis
Susan Bayliss Mallory, Alanna Bree, Peggy Chern in Illustrated Manual of Pediatric Dermatology, 2005
Sebaceous gland hyperplasia Major pointsProminent sebaceous glands present in the newborn periodAffects up to 50% of term infants; less common in premature infantsCharacteristic pinpoint yellow papules with no surrounding erythema (Figure 2.3)Location: nose, cheeks, upper lip and forehead
Diseases of Infancy and Childhood
Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang in Roxburgh's Common Skin Diseases, 2022
Sebaceous hyperplasia is a common and benign condition of the sebaceous glands. In neonates, it results from exposure to maternal hormones. These are multiple white-yellowish tiny papules that commonly occur around the nose and upper lips of full-term infants. Lesions gradually involute, which usually happens within the first few weeks of life.
Ocular surface characteristics in acne vulgaris
Published in Clinical and Experimental Optometry, 2022
Ersin Muhafiz, Murat Öztürk, Remzi Erten
Sebaceous gland hyperplasia accompanied by hyperseborrhea, blockade of sebaceous ducts developing after abnormal follicular keratinisation, and the proliferation of Propionibacterium acnes are the main factors involved in pathophysiology.5,6 As a result of the interaction of these factors, the sebaceous microenvironment changes and inflammatory reactions leading to the progression of the acne lesion occur. Propionic acid secreted by P. acnes causes the formation of irregular morphology in keratinocytes and the development of inflammatory lesions.6 Also, increasing systemic androgen level with puberty causes the proliferation of sebaceous glands and keratinocytes.7
New drugs under investigation for the treatment of alopecias
Published in Expert Opinion on Investigational Drugs, 2019
Jorge Ocampo-Garza, Jacob Griggs, Antonella Tosti
Setipiprant is a selective oral antagonist to the PGD2 receptor [58]. Garza et al. reported that PGD2 is highly expressed in the scalp of men with AGA, and demonstrated that high levels of PGD2 induced miniaturization, sebaceous gland hyperplasia, and alopecia in mice [59]. A phase 2A study of setipiprant tablets in AGA in males was completed (NCT02781311), which evaluated the safety, tolerability, and efficacy of the oral administration of setipiprant 1000 mg twice daily relative to placebo. The clinical trial results for AGA are not yet available. However, setipiprant has already shown to be safe and well-tolerated in previous clinical trials for allergic disorders [60].
An unusual presentation of eruptive syringomas on the neck
Published in Baylor University Medical Center Proceedings, 2021
Madeline R. Frizzell, Saadeddine S. Saad, Katherine H. Fiala
Adding to the diagnostic conundrum was the concurrent presence of juxtaclavicular beaded lines. This is a benign anatomical variant of sebaceous hyperplasia presenting as parallel lines of papules resembling strings of pearls usually localized in juxtaclavicular areas, but also commonly found at the nape of the neck, inguinal region, and axillae.5 While this entity is commonly reported in dark-skinned adults, there are minimal reports of fair-skinned and prepubescent children presenting with this variant of sebaceous hyperplasia. The etiology is unknown; however, hormonal influences, sun exposure, and links to corticosteroid treatment have been noted.5
Related Knowledge Centers
- Acne
- Hair Follicle
- Papule
- Sebaceous Adenoma
- Skin
- Sebaceous Gland
- H&E Stain
- Sebaceous Carcinoma
- Skin Condition