Psoriasis and lichen planus
Ronald Marks, Richard Motley in Common Skin Diseases, 2019
Psoriasis is important because of its frequency, its recurrent nature and its tendency to disable a significant proportion of its victims. Psoriasis is a common, genetically determined, inflammatory skin disorder of unknown cause, which, in its most usual form, is characterized by well-demarcated, raised, red scaling patches that preferentially localize to the extensor surfaces. Psoriasis affects the extensor aspects of the trunk and limbs preferentially. Flexural lesions, which occur in some patients, are most often seen in the major body folds in the elderly, especially in those who are overweight. Psoriasis is a life-long disorder subject to unpredictable remissions and relapses. The commonest variant is hypertrophic lichen planus, in which thickened, mauvish papules, nodules or plaques of irregular shape with a warty or scaling surface develop. Lichen planus appears to be in the general category of autoimmune diseases and patients affected by it have a higher frequency of other autoimmune disorders than a comparable unaffected population.
Psoriasis and lichen planus
Anupam Das, Sumit Sethi in Concise Dermatology, 2021
Small plaque psoriasis occurs at any age and responds well to treatment such as phototherapy. In erythrodermic psoriasis, the characteristic plaque-like lesions disappear and progress to generalized, diffuse skin involvement. The same is true of erythrodermic psoriasis and generalized pustular psoriasis, which require systemic treatment. The term 'lichenoid' refers to the histologic description of inflammatory infiltrate and basal cell liquefaction and used to characterize the pathology of diseases resembling lichen planus. Lichen planus occurs between the third and the fifth decades of life without any specific gender or race predilection. Lichen planus tends to involve the flexor aspects of extremities, wrists, arms, and legs in a bilaterally symmetric distribution. Lichen planus is one of the primary causes of scarring alopecia on the scalp. Lichen nitidus is a variant of lichen planus in which many tiny, pale, flat-topped papules develop in clusters. Bullous lichen planus is a very rare variant in which blistering occurs due to bullae forming sub-epidermally in lesions.
Dermatology
Kristen Davies in Core Conditions for Medical and Surgical Finals, 2020
The differential diagnosis of atopic eczema includes psoriasis, allergic contact dermatitis, seborrhoeic dermatitis or a skin infection. Eczema is chronic, inflammatory skin condition characterised by papules and vesicles on an erythematous base. The aetiology of eczema is fully understood but factors such as genetic predisposition, dysfunction of the skin barrier and immune system dysfunction are thought to play a part. Atopic eczema typically presents as an intense, itchy, erythematous rash on the flexure surfaces, sparing the groin and axillary regions. The rash typically starts in childhood and is episodic in nature. Patients classically present with well-demarcated raised erythematous scaly plaques on the extensor surfaces and scalp. The differential diagnosis for psoriasis includes eczema, seborrhoeic dermatitis, fungal skin infection, cellulitis, secondary syphilis, lichen planus and discoid lupus erythematosus. Guttate psoriasis may present similarly to pityriasis rosea. Basal cell carcinoma is cancer derived from the basal cells of the epidermis.
Metabolic Syndrome May Exacerbate Macular and Retinal Damage in Psoriasis Vulgaris
Published in Ocular Immunology and Inflammation, 2019
Selma Korkmaz, Hande Güçlü, Esra Şüheda Hatipoğlu, Sezin Fıçıcıoğlu, Vuslat Gürlü, Sadık Altan Özal
Purpose: To evaluate whether cases with both psoriasis and metabolic syndrome are prone to retinal and macular changes. Materials and Methods: A total of 174 eyes of 87 subjects were evaluated. Of the 87 subjects, 24 had psoriasis, 19 had psoriasis and metabolic syndrome, 18 had metabolic syndrome only and 26 were healthy subjects. Biochemical analysis, anthropometric, blood pressure and optical coherence tomography measurements and thickness analysis were obtained for each case. Results: The superior retinal nerve fibre layer thickness was significantly lower in the psoriasis and metabolic syndrome group than in the psoriasis group. For all parafoveal quadrants, the ganglion cell complex thickness was statistically significantly lower in the psoriasis group than in the healthy group. The central macula was thinnest in the healthy group among the four groups. Conclusions: Psoriasis can cause retinal changes, and metabolic syndrome may cause additional damage in the retina and macula in cases with psoriasis.
Review of European registries for psoriasis
Published in Journal of Dermatological Treatment, 2019
Mina Amin, Erica B. Lee, Tina Bhutani, Jashin J. Wu
Background: Patient registries are databases that contain clinical data for patients with a specific disease or medical condition. Objective: The purpose was to identify psoriasis registries in Europe and examine their characteristics and implications. Methods: We searched Google, the Registry of Patient Registries, and ClinicalTrials.gov to generate a list of European psoriasis registries. We also conducted a literature review for publications related to the psoriasis registries in Europe using PubMed. Results: We identified 13 psoriasis patient registries in Europe. Conclusions: Patient registries are routinely used in dermatology and psoriasis registries offer pertinent long-term safety information regarding conventional systemic therapies and biologic agents for psoriasis.
Scalp psoriasis: report of efficient treatment with secukinumab
Published in Journal of Dermatological Treatment, 2018
Giuseppe Pistone, Giovanna Tilotta, Rosario Gurreri, Salvatrice Curiale, Maria Rita Bongiorno
Background: Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the population in the world. The scalp is the most common, and frequently the first site of disease involvement. Occasionally it may be the only localization of psoriasis. Objective: Treatment of scalp psoriasis is often unsatisfactory, due to limited available topical therapy and reduced efficacy of some systemic drugs. Biologic therapies are recommended for severe psoriasis, resistant to topical treatment, but evidence from randomized, controlled studies is lacking regarding effectiveness on scalp-localized lesions. The aim of this paper is to show our experience on the efficacy of secukinumab on scalp psoriasis involvement. Methods: Adult patients with moderate to severe plaque psoriasis located in the scalp, who were eligible for biological therapy were selected for treatment with secukinumab. Results and Conclusion: Several clinical studies have shown the efficacy of secukinumab on plaque psoriasis, and some encouraging experience suggest the use in difficult sites such as the scalp; this article reports effective treatment with secukinumab of a series of patients with plaque and scalp psoriasis.