Antibiotics Commonly Used for Skin Infections
Sarah H. Wakelin, Howard I. Maibach, Clive B. Archer in Handbook of Systemic Drug Treatment in Dermatology, 2015
Other adverse effects include the following: Jaundice and hepatitis.Taste disturbance, oesophagitis, oesophageal ulceration.Hypersensitivity reactions including urticaria, anaphylactoid reactions.Dermatological: generalized mild–moderate morbilliform-like skin rashes are the most frequently reported rashes. Rare cases of erythema multiforme, Stevens–Johnson syndrome, pruritus, vaginitis, exfoliative or vesiculobullous dermatitis and toxic epidermal necrolysis have been reported.Induration, pain and abscess formation after i/m injection; thrombophlebitis after i/v injection.Haematological adverse effects include eosinophilia, neutropenia and thrombocytopenia.
Antiepileptic Drugs
Sahab Uddin, Rashid Mamunur in Advances in Neuropharmacology, 2020
The initial effect is sedation which is present in almost all patients on initiation of therapy, but on chronic treatment, it disappears due to development of tolerance. Nystagmus and ataxia occur at excessive dosage (Misty et al., 2018). Phenobarbital can cause hyperactivity and irritability in children and, confusion and agitation in the elderly patients. Scarlatiniform or morbilliform rash, and other manifestations of drug allergy can occur. Hypoprothrombinemia with hemorrhage can occur in the newborn babies of mothers who receive phenobarbital during pregnancy; it can be prevented by administration of vitamin K prophylactically. Similar to phenytoin, megaloblastic anemia and osteomalacia can occur with long-term administration of phenobarbital therapy (Misty et al., 2018).
Checkpoint 4 (Safety-netting): predicting skills
Roger Neighbour in The Inner Consultation, 2018
PLAN includes not only your advice, treatment and medication, but also your safety-net: the measures you might take if the problem persists. In the example just given, a SOAPed entry might run: S – off colour 2/7. Rash today.O – T 39°C, morbilliform rash. No Koplik’s.No neck stiffness.A – viral, ? measlesBut no known contact.?? rubella, ??? meningococcal meningitis.P – symptomatic, tepid sponge.Mother to telephone if rash alters, or if child appears to worsen.Warn duty doctor, ? need to admit.
Cutaneous manifestations of COVID-19 in skin of color: a firsthand perspective of three cases in a tertiary care center in India
Published in Postgraduate Medicine, 2021
Shivam Goyal, Smitha Prabhu, Shashikiran U, Sathish B. Pai, Afsal Mohammed
Exanthematous or morbilliform rash has been noted mostly on the trunk, either at disease onset or at the time of recovery [4]. Pernio (chilblain)-like acral lesion or ‘COVID toes’ present across the age spectrum as purpuric or erythematous macules over fingers, elbows, toes, and lateral aspect of feet [5]. Resolution occurs in 2 to 8 weeks. Rarely, it can progress to recalcitrant digital ischemia [6]. Acute urticaria is the next common finding noted with or without concomitant fever [1–3,11]. The varied cutaneous findings have also been described in pregnancy in a case report where maculopapular rash and urticaria-like lesions were simultaneously present [7]. Recently HZ has been suggested as an alarming sign for a recent subclinical SARS CoV2 infection [8,9]. Retiform purpura has also been described as one of the cutaneous findings [10].
Angiotensin converting enzyme and angiotensin converting enzyme inhibitors in dermatology: a narrative review
Published in Expert Review of Clinical Pharmacology, 2022
Yang Lo, Tsen-Fang Tsai
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [63]. Nearly all human organs express angiotensin-converting enzyme 2 (ACE2) [64] and is associated with SARS-CoV-2 due to the fact that ACE2 acts as the entry co-receptor for SARS-CoV-2 [65,66]. The prevalence of COVID skin rashes has been variably reported to range between 5% and 70% [67]. There are several mucocutaneous manifestations caused by COVID-19 [67,68], including morbilliform rashes, chilblain-like acral lesions and livedo reticularis-like patterns [67]. More oral lesions were identified in older patients and more severe cases of COVID-19 [68]. However, COVID-19 RNA was not detected in the COVID skin rashes [69]. Currently, the effect of ACEI treatment on the cutaneous manifestation of this pandemic has not yet been reported. On the other hand, isotretinoin, a retinoid acid which is commonly used for acne, can also be a treatment choice for COVID-19, due to its property of down regulation of the ACE2 receptor [70]. Moreover, there are also several drugs used in dermatology that could modify ACE2 expression, such as vorinostat and dexamethasone, but the exact role of these drugs for COVID-19 needs further study [71].
Baclofen-induced toxicity in renal disease with neurotoxicity and skin rash
Published in Baylor University Medical Center Proceedings, 2019
Lakshmi Kant Pathak, Ambarish Athavale, Ian Martinez
In very rare cases, toxicity can present as a morbilliform rash that tends to improve with withdrawal of the medication. In a published series of four cases, patients who were treated with baclofen for alcohol dependence developed a morbilliform rash at different treatment doses, indicating that the rash was dose independent and an idiosyncratic reaction.4 Baclofen has a low molecular weight, low volume distribution, and low protein binding capacity, making it easy to dialyze. Although the percentage of clearance varies with each person and the duration of hemodialysis session, it can be up to 79% cleared in one treatment session, with rapid neurological improvement after two sessions.5
Related Knowledge Centers
- Dengue Fever
- Maculopapular Rash
- Measles
- Neisseria Meningitidis
- Petechia
- Rash
- Lesion
- Kawasaki Disease
- Skin Condition
- Waterhouse–Friderichsen Syndrome