The red glans penis
Manu Shah, Ariyaratne de Silva in The Male Genitalia, 2018
Drugs that have been implicated in fixed drug eruption are listed below: amoxicillinbarbiturateschlordiazepoxidedapsoneoxyphenylbutazoneparacetamolphenolphthaleinpropranololquininesalicylatessulphonamidestetracyclines.
Garenoxacin
M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson in Kucers’ The Use of Antibiotics, 2017
Serious hypersensitivity reactions to fluoroquinolones are rare. The only reports of hypersensitivity to garenoxacin are from clinical trials. Among 987 trial patients receiving garenoxacin, two cases of allergic reactions were put into the severe or very severe drug-related adverse drug reaction category (EMEA, 2007). Cross-reactivity between garenoxacin and other quinolones may not occur, and garenoxacin has been given safely after confirmed anaphylaxis associated with levofloxacin (Fukushima et al., 2012). A single case of fixed drug eruption has been reported (Miyake et al., 2013).
Acne, rosacea and similar disorders
Ronald Marks, Richard Motley in Common Skin Diseases, 2019
Side effects of the tetracyclines are few and not usually serious. Gastrointestinal discomfort and diarrhoea occasionally occur. Photosensitivity was mainly a problem with older, now no longer used, analogues. Fixed drug eruption and, rarely, other acute drug rashes develop. Minocycline can cause a dark-brown pigmentation of the skin or acne scars or acral areas on the exposed parts of the skin after long-continued use in a small number of patients. Minocycline may also provoke a rare reaction similar to drug-induced lupus erythematosus with hepatitis, arthritis and pneumonitis.
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect
Published in Acta Clinica Belgica, 2019
Fatma Erden, Erol Rauf Agis, Meside Gunduzoz, Omer Hinc Yilmaz
Drug eruptions are substantially common dermatological problems and can be seen in about 2.2% of inpatients [1]. Drug reactions are often maculopapular or morbilliform, but there are different types. Rather than a laboratory study, images of lesions, drug use history, clinical status of the patient, and histopathological findings in some cases help diagnosis. One of these situations is fixed drug eruptions. Fixed drug eruptions (FDE) are characterized by recurrent, usually solitary erythematous or dark red macular, plaque or bullous lesions, all at the same site [2,3]. There are many drugs that can trigger this clinical picture. Drugs often accused include sulfonamides, dapsone, barbiturates, nonsteroidal anti-inflammatory drugs, tetracycline, and carbamazepine [4]. Among the first choices for antidotal treatment in mercury exposure, DMPS (Dimaval®) is generally a drug with a low incidence of side effects. Fixed drug eruption due to DMPS was not detected in our literature review and so we aimed to present this rare case [5].
Protocols for drug allergy desensitization in children
Published in Expert Review of Clinical Immunology, 2020
Lucia Diaferio, Mattia Giovannini, Evangéline Clark, Riccardo Castagnoli, Davide Caimmi
DDS is contraindicated in patients reporting a history of type II and type III reaction, because the interaction between the antigen and the antibody may possibly lead to the activation and consumption of the complement system [21]. On the other hand, DDS has been proposed for type IV delayed reactions, in patients without a history of severe symptoms, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). There is only little literature data concerning the mechanism of desensitization in cell-mediated reactions [15]. The process seems to be mediated by the recruitment and activation of T regulatory (Treg) cells. Teraki et al. [22] showed that, in patients with a history of fixed drug eruption (FDE) caused by allopurinol, the number of intralesional skin Treg cells increased significantly after desensitization, whereas the number of CD8+ T cells decreased, suggesting a suppressive effect on the effector function of CD8+ T cells by desensitization-induced Treg cells. Similar findings have been reported for FDE caused by phenytoin [23,24].
Recent developments in drug hypersensitivity in children
Published in Expert Review of Clinical Immunology, 2019
Ilknur Kulhas Celik, Emine Dibek Misirlioglu, Can Naci Kocabas
Identifying an alternative drug is very important for the clinical management of epilepsy in patients with suspected DHRs to AEDs. Clinical cross-reactivity is usually reported among conventional aromatic AEDs such as CBZ, PB, and PHT; however, different studies have also reported that cross-reactions with newer aromatic AEDs (OXC and LTG) are possible at rates of 15% to 70% [82,85,95,96]. Desensitization can be considered for selected patients with mild nonimmediate reactions such as MPE, nonspecific rash or fixed drug eruption, and AGEP. However, this procedure is contraindicated for serious hypersensitivity reactions like SJS, TEN, DRESS, vasculitis, and organ-specific reactions [97].
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