In-Vitro Antidermatophytic Bioactivity of Peel Extracts of Red Banana (Musa Acuminate) and Common Banana (Musa Paradisica)
Megh R. Goyal, Durgesh Nandini Chauhan in Assessment of Medicinal Plants for Human Health, 2020
Investigators and healers of conventional medicines have documented health benefits of therapeutic plants to treat dermatological diseases. The ring worm is known as dermatophytes. The three main genera—Microsporum, Trichophyton, and Epidermophyton—are strongly allied plant—scientifically. Among these, Microsporum is a recurrent reason for ring worm of scalp and might furnish augment to ring worm in all parts of the carcass. While Trichophyton cause ringworm from the scalp as well as erstwhile areas of crust and nails. Epidermophyton is mainly accountable to ringworm affecting surface of the skin, hands, and feet; and has been found to interlace within the skin, and it does not assault tresses.15Candida species establishes in the gastro-intestinal tract, oral cavity, and vagina.3
Nigella sativa Encapsulated Nano-Scaffolds and Their Bioactivity Significance
Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi in Biomarkers as Targeted Herbal Drug Discovery, 2022
N. sativa and its extract act against Candida albicans and Madurella mycetomatis. The activity of the extracts of N. sativa was claimed to be potentially more effective than antibiotics like amphotericin-B and griseofulvin against Aspergillus niger, Fusarium solani, and Scopulariopsis brevicaulis. Moreover, TQ confirmed potential activity against Trichophyton spp., Epidermophyton spp., and Microsporum spp. Aqueous extracts of N sativa showed no antifungal activity. The plant extract of N. sativa caused a significant inhibition of the growth of the fungi, Candida albicans (Aljabre et al., 2015). Size reduction of Amphotericin-B, Ketoconazole, and Thymoquinone was attempted by the ball milling technique, and particle size was found to be 5 to 20 nm. The nanoparticulated drug and the conventionally available microstructured drug form were examined against Candida albicans yeast and candida biofilm. Prepared nanosized drug particles were found to be two or four times effective in both candida yeasts and candida biofilm (Randhawa et al., 2015).
Dermatophytes
Rossana de Aguiar Cordeiro in Pocket Guide to Mycological Diagnosis, 2019
Epidermophyton floccosum, Microsporum audouinii, and Trichophyton schoenleinii have been the main pathogens causing superficial fungal diseases in the past 100 years, but their frequencies have declined dramatically since the 1950s, and are now limited to some developing countries. On the other hand, other species, like Trichophyton tonsurans, have become the main agent of tinea capitis in several European countries, especially the United Kingdom and France, as well as in the United States, Japan, Africa, and the Caribbean, leading to its classification as an emerging pathogen (Bouchara et al., 2017).
Development of a new synthetic xerogel nanoparticles of silver and zinc oxide against causative agents of dermatophytoses
Published in Journal of Dermatological Treatment, 2019
Ali Abdul Hussein S. Al-Janabi, Abass M. Bashi
Dermatophytes, a very special group of fungi, including three genera: Trichophyton spp., Microsporum spp., and Epidermophyton spp. (1). They often cause a superficial skin disease called dermatophytoses or tinea on different parts of the human body (1,2). Several types of antifungal agents are commonly used for treatment of this type of infection. Synthesis of some of these agents in nanoparticles size is suggested to increase their antifungal effects. Silver nanoparticles (Ag-NPs) are considered one of the most important antimicrobial molecules. Although antidermatophytic activity is less than some of antifungal agents such as griseofulvin, Ag-NPs in pure form or in combination with other compounds revealed effective action against several species of dermatophytes (3–5), which may be higher than other antifungal agents such as with fluconazole (3,5). Moreover, curative ability of Ag-NPs against dermatophytoses is also proved by many studies (6,7). Zinc oxide nanoparticles (ZnO-NPs) are another antifungal agents that have ability to inhibit several types of fungi (8–10). It revealed potent effects against dermatophytes after direct exposure to it or its preparations (11–14). Gel preparation of Ag-NPs or ZnO-NPs showed an active effect against several types of fungi such as Candida lusitaniae and Aspergillus niger (15,16).
Zoonotic fungal diseases and animal ownership in Nigeria
Published in Alexandria Journal of Medicine, 2018
Adebowale I. Adebiyi, Daniel O. Oluwayelu
Dermatophytosis is an integumentary mycotic disease prevalent in both sporadic and epidemic forms in over 145 countries of the world, and is of public health and economic significance. It is an important occupational mycozoonoses of dairymen, animal handlers, livestock farmers, pet owners, veterinarians, etc.15 caused by a group of highly specialized pathogenic fungi collectively referred to as “dermatophytes”, which are the most common agents of superficial mycoses in animals and humans, and are thus recognized as a public health menace worldwide.16–20 This group of closely related fungi comprising 40 identified species in the dermatophytic genera that include Microsporum, Trichophyton and Epidermophyton21 cause infection of the stratum corneum of the epidermis and keratinized tissues such as skin, hair and nails of humans and animals.22,23
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea
Published in Drug Delivery, 2021
Adel F. Alghaith, Sultan Alshehri, Nabil A. Alhakamy, Khaled M. Hosny
Superficial fungal infections, such as tinea, are one of the most prevailing infections worldwide primarily caused by dermatophytes of the genera Epidermophyton, Microsporum, and Trichophyton (Branscomb, 2005). Such aerobic pathogenic fungi can grow and colonize on keratinized tissues like skin, hair and nails, owing to their ability to produce numerous proteolytic enzymes that can digest keratin (Branscomb, 2005). These infected keratinized tissues provide the desired temperature, pH, and nitrogen conditions to meet the nutritional needs of dermatophytes; therefore, such infections are restricted to superficial cutaneous tissues and rarely extend to deeper subcutaneous ones (Bottone, 2006). Although several antifungals have been reported to have essential activity against dermatophytes, such infections often relapsed after the medication was stopped since these organisms established a tolerance to prolonged treatment (Mukherjee et al., 2003).
Related Knowledge Centers
- Fungal Infection
- Tinea Corporis
- Tinea Cruris
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