New Trends in Anti-Aging Skin Care
Andreia Ascenso, Sandra Simões, Helena Ribeiro in Carrier-Mediated Dermal Delivery, 2017
Dermabrasion is the process of uniform mechanical abrasion of the skin, including the epidermis and upper papillary dermis layers, and consequently removes or reduces superficial wrinkles. It can be performed by using a serrated wheel, diamond embedded fraises, wire brush or sterilized sandpaper as a cutting tool, which is attached to a rotating handpiece electrically powered. However, this technique is highly dependent of the operator, requiring specialized skills and experience since any inaccuracy may result in major scarring. The healing time can be extended to one month. Once more, patients with darker skin may experience dyspigmentation. This technique tends to be replaced with or used simultaneously with resurfacing lasers [52,55,56].
Physical and Technological Modulation of Topical and Transdermal Drug Delivery
Marc B. Brown, Adrian C. Williams in The Art and Science of Dermal Formulation Development, 2019
Other techniques for the selective removal of outer skin layers have been used for improving drug delivery – for example, chemical peels can remove layers varying from the superficial stratum corneum to the epidermis, or even to the dermal tissue. Radiofrequency (RF) thermal ablation involves placing a thin, needle-like electrode directly into the skin and applying high frequency alternating current (~100 kHz) which produces microscopic pathways in the stratum corneum through which drugs can permeate. Adhesive tape can be used to sequentially remove stratum corneum layers. Additionally, dermabrasion can be used to remove the stratum corneum, or even the deeper skin layers; it is akin to simply using “sandpaper” on the skin, by firing aluminium oxide crystals at localised areas of the skin to remove tissue. As with the laser treatment, flux of both lipophilic and hydrophilic molecules would be expected to increase, but at present the technology appears only suited to local (i.e., in the vicinity of the application, not systemic) drug delivery. One apparently successful approach has to be the use of microporation with a dry patch. In Nitto’s PassPort® Active Transdermal Platform, a disposable portable device ablates the skin to create micropores in the stratum corneum through which small APIs and biologic drugs can penetrate down into the systemic circulation.
Dermabrasion in Vitiligo
Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan in Comprehensive Textbook on Vitiligo, 2020
Vitiligo is a cumbersome pigmentary disorder characterized by loss of melanocytes from the skin and subsequent development of depigmented patches of variable sizes that may enlarge and coalesce to form extensive areas of leukoderma [1]. There are many forms of treatment available for vitiligo. Up to 80% of patients suffering from vitiligo respond to medical treatment [2,3]. However, when the disease becomes stable and refractory to medical treatment, surgical treatment may be the only viable option to replenish the lost melanocytes. Dermabrasion is an extensively used surgical modality for treating many cutaneous problems like facial scars, acne, stable vitiligo, hyperkeratotic lesions, pigmentation, tumors, actinic lesions, and removal of tattoos [4].
Treatment of rhinophyma with the Versajet™ Hydrosurgery System and autologous cell suspension (ReCELL®): A case report
Published in Journal of Cosmetic and Laser Therapy, 2018
Yıldız K., Kayan B. R., Dulgeroglu T., Guneren E.
Many different modalities have been described in treatment. Medical therapy, in the form of topical and oral antibiotics and retinoids, is used for the treatment of acne rosacea. However, it has failed to prevent the progression of rosacea into rhinophyma or aid regression of the latter (1). Surgical management therefore remains the mainstay of treatment for established rhinophyma. Dermaplaning and dermabrasion have had long-standing popularity with favorable results. Other modern techniques include electrocautery, ablative lasers, ultrasonic scalpels (3), and radio frequency ablation. Versajet™ Hydrosurgery System has been previously described in the treatment of rhinophyma (4). By our present study, we demonstrated combined use of the Versajet™ Hydrosurgery System and autologous cell suspension (ReCELL®) in a rhinophyma patient.
A 2017 update: Challenging the cosmetic procedural delay following oral isotretinoin therapy
Published in Journal of Cosmetic and Laser Therapy, 2019
Katherine Ann McDonald, Amanda Jane Shelley, Tadeusz Pierscianowski, Afsaneh Alavi
The 2017 literature highlights the movement to disband the delay for all previously implicated cosmetic procedures (both surgical and clinical), except for full-face dermabrasion, mechanical dermabrasion, and fully ablative treatment (Figure 1) (3,7). Multiple publications within the last year have provided new higher quality evidence and relayed expert opinion (1–3,6–8). Specifically, the new articles address the shortcomings documented in the March 2017 systematic review (1) by incorporating the Delphi process and all key patient factors related to atypical scarring. This article encourages clinicians to alter their cosmetic practice considering this new evidence. To support this change in practice, governing bodies and pharmaceutical companies should revise the drug monograph and consumer guidelines to be in line with this evidence. A unified update in cosmetic practice and acceptance of the new algorithmic approach will provide greater clarity for patients and reduce concerns over removing the delay.
Clinical evaluation and in-vivo analysis of the performance of a fractional infrared 1550 nm laser system for skin rejuvenation
Published in Journal of Cosmetic and Laser Therapy, 2018
W. James Tidwell, Courtney Green, Daniel Jensen, E. Victor Ross
Inclusion criteria were healthy males or females between 18 and 75 years old, Fitzpatrick skin type I–V, and those exhibiting facial areas with visible photodamage and/or acne scars. Pts were instructed to use daily sunscreen for the duration of the study. Exclusion criteria included pregnancy or breastfeeding, hypersensitivity to anesthetic agents, and a history of herpes simplex in the treated area, keloid scarring, immunosuppression, or a thromboembolic condition. Those who had had a face lift or eyelid surgery within a year, dermabrasion or chemical peel treatment within 3 months, neurotoxin within 6 months, collagen injections within the past 9 months, and oral retinoids within 6 months of the study were also excluded.
Related Knowledge Centers
- Abrasion
- Acne
- Cold Sore
- Dermatology
- Wound Healing
- Dermis
- Skin
- Plastic Surgery
- Local Anesthetic
- Carbon-Dioxide Laser