Minocycline
M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson in Kucers’ The Use of Antibiotics, 2017
Various minocycline-induced hypersensitivity reactions with eosinophilia and systemic involvement have been characterized by rash, cutaneous eruption, fever, lymphadenopathy, eosinophilia, hepatitis, and involvement of the kidneys, lung, and heart (Walker et al., 1979; Wilkinson et al., 1989; Sitbon et al., 1994; Fletcher and Sellars, 1996; Christe et al., 2000; Kiessling et al., 2001). Severe side effects such as anaphylaxis, Stevens–Johnson Syndrome, DRESS, and persistent myocarditis have all been reported (Talsania and O’Toole, 2009; Eshki et al., 2009; Shaughnessy et al., 2010; Yoon et al., 2010; Jang et al., 2010; Kanno et al., 2014). Minocycline-induced hemolytic anemia and thrombocytopenia can occur, but these are rare (Kudoh et al., 1994; D’Addario et al., 2003). Minocycline was also identified as the causal agent of Sweet’s syndrome (acute febrile neutrophilic dermatosis) (Mensing and Kowalzick, 1991; Thibault et al., 1992; Kalai et al., 2012). Severe acute myopathy with elevated muscle enzyme levels have been observed in patients receiving minocycline (Narvaez and Vilaseca-Momplet, 2004).
Miscellaneous Causes Of Unexplained Fever
Benedict Isaac, Serge Kernbaum, Michael Burke in Unexplained Fever, 2019
We do not know the exact nosologic situation of these cases. They could be linked with the well-known various aspects of streptococcal allergies. For example, those presenting like “serum sickness”,19 cutaneous vasculitis,20 or, even more disturbing, polyarteritis nodosa.21 Clinically, they are not very different from adult Still’s disease (see Chapter 18). They also have common features with the acute febrile neutrophilic dermatosis of Sweet.22 They are very close, if not identical, to subsepsis allergica of Wissler.23
Diagnosis of IBD
Peter Sagar, Andrew G. Hill, Charles H. Knowles, Stefan Post, Willem A. Bemelman, Patricia L. Roberts, Susan Galandiuk, John R.T. Monson, Michael R.B. Keighley, Norman S. Williams in Keighley & Williams’ Surgery of the Anus, Rectum and Colon, 2019
Sweet’s syndrome (acute febrile neutrophilic dermatosis) is a rare dermatologic EIM of IBD which is associated with active disease. It manifests as tender papulosquamous exanthema or nodules involving the arm, legs, trunk, hands or face.127 Anti-TNF treatment can induce paradoxical inflammation of the skin which is usually reversible upon drug cessation. Skin lesions (psoriasiform eczema, eczema and xerosis) are reported in approximately 22% of patients treated on anti-TNF therapy.132
Histiocytoid Sweet syndrome successfully treated with etanercept
Published in Baylor University Medical Center Proceedings, 2018
Ian T. Watson, Isabel Haugh, Alexis R. Gardner, M. Alan Menter
Requena et al were the first to describe this variant of acute febrile neutrophilic dermatosis in a series of 41 patients.2 A mononuclear infiltrate with a histiocytic morphology and an immunohistochemical staining profile suggestive of immature myeloid neutrophil precursor cells was observed in tissue taken from these patients. CD68, a pan-histiocytic marker, and myeloperoxidase, a marker of myeloid cells, were diffusely expressed in lesional cells with histiocytic morphology.2,6 Peripheral blood analysis may be indicated to rule out leukemia cutis, due to strong myeloperoxidase expression in cutaneous lesions of both conditions.2 Diagnosis of HSS is based on the presence of skin lesions with biopsy-proven histiocytoid infiltrate.7,8
Multiple painful plaques and the Sweet’s syndrome
Published in Baylor University Medical Center Proceedings, 2022
Debra Lee, Daniel Baird, Michelle Tarbox
Acute febrile neutrophilic dermatosis, also known as Sweet’s syndrome (SS), traditionally manifests as acute onset fever, neutrophilia, and painful cutaneous lesions. These lesions appear as purple-red papules and plaques that are often distributed asymmetrically across the face, neck, and upper extremities. SS is characterized histologically by a diffuse infiltrate predominantly composed of mature neutrophils in the dermis. It is a rare inflammatory skin disease of unknown origin, associated with a multitude of diseases, infections, malignancies, and medications.
Related Knowledge Centers
- Fever
- Histology
- Infiltration
- Papule
- Leukocytosis
- Neutrophil
- Streptococcus
- Erythema
- Skin Condition
- Acute Myeloid Leukemia