Inflammatory Bowel Disease
Mary J. Marian, Gerard E. Mullin in Integrating Nutrition Into Practice, 2017
Boswellia serrata is a plant native to India, which has been used for hundreds of years as a herbal remedy for inflammatory conditions. B. serrata is a leukotriene inhibitor leading to a blunted release of pro-inflammatory cytokines explaining its anti-inflammatory effects [106]. Gupta et al. demonstrated an improvement in 70% of UC patients treated with B. serrata, which was equally as effective as sulfasalazine therapy [107]. Gerhardt et al. found that B. serrata was equivalent to mesalamine in the treatment of CD [108]. A double-blind randomized controlled trial of 108 patients confirmed the safety and patient tolerability of B. serrata, although it was not efficacious in maintaining remission in CD patients after 52 weeks of therapy [109]. Another study demonstrated a possible improvement of collagenous colitis treated with B. serrata, although due to a high drop-out rate, only the per-protocol analysis was statistically significant.
Lessons to Be Learnt from Ayurveda
D. Suresh Kumar in Ayurveda in the New Millennium, 2020
The pods and nuts of the herb shikakai (Acacia concinna) are widely used in shampoos. The pods have neutral pH in aqueous suspension and are used to make mild detergent rich in saponins. Similarly, Sapindus trifoliatus (soapnuts) contains saponins that are used as a foaming agent that takes the place of soap in ayurvedic tradition (Jain et al. 2010b). Āmla (Emblica officinalis) with its rich content of vitamin C has importance in rejuvenation of both body and hair. As advised by Caraka, the regular intake of āmla can delay the aging process (Murari et al. 2013). Boswellic acid obtained from Boswellia serrata inhibits enzymes like 5-lipoxygenase, responsible for inflammation and skin damage (Preetha and Karthika 2009). The clear gel of Aloe vera has the ability to heal wounds, ulcers and burns by forming a coating over areas that are affected, and helps in healing. Besides providing protection against skin infections and reducing wrinkles, Aloe vera finds its place in shampoo that improves dry and brittle hair (Jain et al. 2010b).
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Christophe Wiart in Medicinal Plants in Asia for Metabolic Syndrome, 2017
Boswellic acid from Boswellia serrata Roxb. ex Colebr. inhibited rat lens aldose reductase, rat kidney aldose reductase and human recombinant aldose reductase activities with IC50 values equal to 5, 6, and 3.9 μg/mL, respectively.162 In Wistar albino rats fed with galactose for 14 days, daily administration of boswellic acid at a dose of 10 mg/kg reduced lens aldose reductase catalyzed production of galactitol by 74%.162 Methanol extract of oleogum resin from another member of the genus Boswellia Roxb. ex Colebr. given orally to Wistar rats at a dose of 400 mg/kg/day for 30 days before subcutaneous administration of isoprenaline-lowered serum aspartate transaminase, lactate dehydrogenase, and creatinine by 30%, 45%, and 60%.215 The extract reduced lipid peroxidation in myocardium by about 60%.215 Besides, this treatment prevented myonecrosis and myocardial edema and lowered.215
Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome
Published in Expert Opinion on Pharmacotherapy, 2020
Akhil Munjal, Bhavtosh Dedania, Brooks D. Cash
Boswellia serrata is a moderate to large-sized branching tree that grows in dry mountainous regions of India, Northern Africa, and the Middle East. An oleo-gum resin is derived through trunk tapping after which oil content is separated from the resin. Gum-resin extracts of Boswellia serrata contain monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and pentacyclic triterpenic acids and have been used in folk medicine for centuries to treat various chronic inflammatory diseases. In murine studies, a significant reduction in lipid peroxidation, nitric oxide levels, and inducible nitric oxide synthase (markers of inflammation) was seen in subjects receiving Boswellia serrata extract (BSE) [51]. Interestingly, in a small (n = 31) double-blindplacebo-controlled multicentre trial of BSE on quality of life, symptoms, and histology in patients with collagenous colitis, it was found that the rates of clinical remission were higher in the BSE treated group at the end of 6 weeks, but there was no change seen in histology and quality of life [52].
The effects of Olibanum on oxidative stress indicators, cytokines, brain derived neurotrophic factor and memory in lipopolysaccharide challenged rats
Published in Toxin Reviews, 2022
Narges Marefati, Farimah Beheshti, Amin Mokhtari-Zaer, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mahmoud Hosseini
Boswellia serrata (B. serrata) from Burseracea family, is identified as Gajabhakshya in Sanskrit (Upaganlawar and Ghule 2009). This plant is a tree with a moderate height, which is cultivated in many countries with dry hills like Arabia, Eastern Africa, and Northwest India (Kimmatkar et al.2003, Upaganlawar and Ghule 2009, Hosseini-Sharifabad and Esfandiari 2015). Since ancient times, the therapeutic properties of dried resinous gum of this plant have been known. The resin obtained from the bark of trees is known as Frankincense (Morikawa et al.2017), Olibanum, Guggul, or incense (Etzel 1996, Kimmatkar et al.2003, Camarda et al.2007a). The traditional anti-inflammatory therapeutic usage of Boswellia Serrata in the past had led to efforts to identify the effective compounds of this plant (Moussaieff and Mechoulam 2009). More than 200 constituents have been known in Boswellia Serrata resin (Camarda et al.2007a) that can be responsible for therapeutic properties in various inflammatory disease like rheumatoid arthritis (Etzel 1996), carcinogenic tumors (Mukerji et al.1970), inflammatory bowel disease (IBS), bronchial asthma (Qurishi et al.2010) osteoarthritis (Kimmatkar et al.2003), chronic colitis (Gupta et al.2001) and leukemia (Shao et al.1998).
Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats: role of hepatic PPAR-α/P38 and cardiac Calcineurin-A/NFATc1/P38 pathways
Published in Archives of Physiology and Biochemistry, 2022
Noura M. Thabet, Mohamed K. Abdel-Rafei, Enas M. Moustafa
Boswellic acids (BA) was obtained from Nature’s Way Products (Springville, Utah, USA) in form of tablets (Each tablet contains 307 mg Boswellia serrata extract (65% boswellic acids).The tablets were then grounded and suspended in 0.9% pyrogen free isotonic saline (0.9% NaCl) delivered from Otsuka Pharmaceuticals, Japan. While the BPA (purity 99%, CAT # 80–05-7, Sigma-Aldrich, St. Louis, MD, USA) was dissolved in 0.01% (v/v) corn oil as a vehicle for fat-soluble compounds (CAT # 8001–30-7, Sigma-Aldrich, St. Louis, MD, USA). All the remaining chemicals and reagents were of the highest quality and analytical grade. Antibodies against p-38, p-p-38, calcineurin-A, NFATc1, PLC-γ and β-actin were obtained from Santa Cruz Biotechnology (Santa Cruz, California, USA).