Electromedicine
Mark V. Boswell, B. Eliot Cole in Weiner's Pain Management, 2005
Magnets and acupuncture are popular modes of treating pain symptoms (Grant, Miller, Winchester, Anderson, & Faulkner, 1999; Karp, 2004). The theory behind the use of magnets in pain management is that the magnet reacts with the iron in the blood to increase blood flow and promote healing. In many recent studies, it has been shown that magnet therapy may show positive effect in certain patients and for certain conditions, but it may not show any beneficial effect in a significant number of patients (Karp, 2004). Magnet therapy has been used for many painful conditions such as foot pain, low back pain, and carpal tunnel syndrome (Karp, 2004). The placebo effect may play an important role in magnet therapy. Karp (2004) states that the decrease in pain reported by subjects wearing magnetic devices was not statistically significantly different compared with placebo-treated groups. However, in a study by Weintraub (Table 82.2), 450 Gauss multipolar magnetic insoles were used in 141 subjects and placebo insoles were used in 118 patients to treat symptomatic diabetic peripheral neuropathy, with constant symptoms for at least 6 months. The results of this study showed beneficial effect of the magnet therapy (Table 82.2 and Table 82.3).
Alternative and Complementary Treatments
Harold G. Koenig in Chronic Pain, 2013
Some scientific evidence suggests that certain pain conditions may benefit from magnet therapy. Brown presented data from a small study of eight patients with chronic pelvic pain at the annual meeting of the American College of Obstetrics and Gynecology in May 2000.22 Investigators placed magnets on two trigger points on the abdomen that elicited pain when pressure was applied. Sixty percent of women treated with magnets experienced a reduction in pain compared to 33 percent of women given “sham” or inactive magnets. Whether this difference was statistically significant was not mentioned. It is not known why the application of magnets would reduce pain; however, magnets may somehow increase blood flow or interfere with nerves conducting painful stimuli.
Renewal Challenges: The Case of the Republic of Georgia
Frederick J. DeMicco, Ali A. Poorani in Medical Travel Brand Management, 2023
Forest-dimming has started in the west of the country since 1928. The region was known for the cultivation of citrus trees and tea. In addition, for the first time, the benefits of magnetic sand were noticed by quarry workers who were using sand in nearby factories. Soon therapeutic properties of sand drew the attention of the community, medical professionals, and research centers. Artificially created magnetic fields are widely used in medicine. Some people use magnet therapy for treating pain, such as foot, back, or joint pain (University of Michigan Health). In-resort Ureki, you can find naturally created low-intensity magnetic field. Above that, the resort has a subtropical climate, sea, and Sun from May to October.
Effects of static magnetic fields on bone microstructure and mechanical properties in mice
Published in Electromagnetic Biology and Medicine, 2018
Jian Zhang, Xiaofeng Meng, Chong Ding, Peng Shang
A growing body of researches carried out over last decades had studied the influences of SMF on mice and rats to evaluate the SMF biological effect. Previous studies showed that SMF had a positive effect on bone because certain exogenous SMF could promote fracture healing, accelerate bone growth and inhibit bone loss in numerous circumstances, such as ischemic bones, bone surgical invasion, bone fracture and bone grafts (Taniguchi et al., 2004; Xu et al., 2011, 2001; Yan et al., 1998). Many investigations substantiated that permanent magnets could stimulate healing of bone fracture (Aydin & Bezer, 2011; Puricelli et al., 2006; Saifzadeh et al., 2007). It was assumed that SMF could increase localized calcium deposition in bone, which allowed for the initiation of osteogenesis (Bassett, 1982). Magnet therapy seemed to be one of the most promising complementary medicines, because side effects are much less than in surgery, chemotherapy and radiotherapy (Yu & Shang, 2014).
Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy
Published in Drug Delivery, 2022
Ning Zhang, Yibin Wu, Weiqi Xu, Zhenjian Li, Lu Wang
They are one of the most sophisticated methods of delivering cytotoxic drugs. Oncologists have authorized the clinical usage of a liposome-based DOX formulation that outperformed free DOX on the therapeutic index (Ledezma-Gallegos et al., 2020; Patel et al., 2020; Barani et al., 2021). Targeting receptors and stimuli-sensitive release inside the tumor can improve the therapeutic effectiveness of liposomal compositions. Hence, it is no wonder that tailored and temperature-sensitive formulas are so popular. Targeting folate receptors in liposomal delivery of drugs to cancerous cells is promising and successful in vitro (Vu et al., 2020). A non-targeted stealth liposome formulation, on the other hand, did not affect the drug concentrations in tumors. The FA receptors are overexpressed in many cancerous cells, comprising those in the kidney, liver, brain, ovary, colon, prostate, and lung. More FA can transfect HT-29 metastasis liver cancer cells, which are positive folate receptors (Chowdhury et al., 2020; Gu et al., 2020; Sonju et al., 2021). HT-29 metastasis liver cancer cells and HT-29 cells do exhibit significant levels of the folate receptor. It is well-known that magnetic nanocomposites have enormous promise in the domains of medication delivery, cancer diagnosis and therapy, and cancer diagnostics and treatment (Ding et al., 2020; Kim et al., 2020; Naumenko et al., 2021). According to a recent study, iron oxide magnetite nanocomposites (MNPs) have been broadly used in pharmaceutical fields because of their high biocompatibility and low toxicity. MNPs with ultrathin particle sizes and extreme magnetizations levels may be controlled by a magnetization to penetrate human tissues, suggesting use for magnetic therapy. The inherent magnetic characteristics of MNPs for drug administration have garnered substantial attention among the vast spectrum of nanomaterials being explored for biomedical applications (Lv et al., 2020). A combination of radiofrequency thermal and drug delivery treatment for cancer may be possible with thermosensitive liposomes. When a solid permanent gradient magnetic field is applied to a target tissue, such as a tumor, MNPs are utilized as potential drug delivery carriers that concentrate in that tissue. T2 (spin–spin relaxation) imaging can also be employed with magnetic liposomes to track their biodistribution in vivo noninvasively using MRI. These nanocomposites are inoculated into the cancer cells and subjected to rotating magnetic fields for this purpose (Dana et al., 2020; Mansoori et al., 2020; Swami Vetha et al., 2020).
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