Phytoconstituent-Loaded Nanomedicines for Arthritis Management
Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi in Biomarkers as Targeted Herbal Drug Discovery, 2022
Herbal remedies, after being an important research area and clinical practice in orthopedics and rheumatology, it is a key priority of physicians and their patients to understand the balance ratio of risk and benefits associated with herbal therapy for the proper management of arthritis, rheumatic conditions, and musculoskeletal pains. With increasing cases of various arthritic conditions (such as Osteoarthritis and other forms), recent studies suggest that available pharmacotherapy is not effective in terms of capability to retain the originality of bone structure and function in diseased conditions. Several problems like less relief of symptom, side-effects with prolonged treatment leads to chronic illness, makes less attractive approach towards conventional medical therapy for the proper treatment of arthritis, and other arthritic conditions indicate a straightforward approach for novel, innovative, safe, and effective alternative treatment for arthritic patients. Natural products may be an answer to the current problem in therapy as most of them have faith that herbals are a natural gift and moreover is a safer option as compared with synthetic drugs. Ethnopharmacology is a new and rapidly developing discipline and involves the study of the use of herbal and medicinal plants by particular cultural groups (Ali et al., 2012).
Antifungal Activity Validation of Wild Plants used in Argentine Ethnomedicine
Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa in Ethnopharmacology of Wild Plants, 2021
The study of medical treatments of different cultures is known as Traditional Medicine or Ethnopharmacology and represents very valuable information that in some cases has led to the discovery of drugs currently in clinical use (Raza 2006). Many other traditional uses of plants caused great curiosity among scientists, who submitted them to pharmacological studies in the laboratory and then to the isolation of their active ingredients. The isolation of bioactive molecules from plants is a laborious and long process, which fortunately has been greatly improved in recent decades thanks to the development of refined separation and isolation methods that make it possible to isolate, from a complex mixture, not only majority but also minority compounds which, many times, possess biological properties (Hostettmann 1991).
Wild Plants as a Treasure of Natural Healers
Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa in Wild Plants, 2020
Traditional medicine is the basis of healthcare to treat various infectious diseases. Although some infectious diseases have been oppressed by modern medicines, new diseases are constantly evolving (Cordell 2002). Thus, one of the fruitful approaches to overcome resistant microbes is to search for new anti-infective agents of plant origin (Farnsworth 1990). There is an enormous wealth of information on cheap and culturally accepted ethnopharmacology-based remedies (Balunas and Kinghorn 2005). Several medicinal plants have been used in traditional medicinal practices for centuries, but until now, scientists have not been able to capitalize on this herbal wealth adequately. Although exploration and preliminary screening of ethnomedicinal plants have been carried out for several species, biomedical research at chemical and molecular level warrants further research (Martin 1995, Balunas and Kinghorn 2005, Bhattarai et al. 2008a, b).
In silico prediction of anticarcinogenic bioactivities of traditional anti-inflammatory plants used by tribal healers in Sathyamangalam wildlife Sanctuary, India
Published in Egyptian Journal of Basic and Applied Sciences, 2018
Pavithra Chinnasamy, Rajendran Arumugam
Ethnopharmacology becomes an important field to elucidate and justify the indigenous medicinal benefits bioactive of plant compounds through various biochemicals and experimental models [1]. India is one among the country which has potent knowledge of ancient treatment of medicinal plants. Tribal people encompass vast recognition of treatment by plant therapy, and their historical knowledge has guaranteed results over novel experimental studies of plants secondary metabolites as a source to draw anti-inflammatory drugs [1[2]–3] . Wound inflammation, especially chronic wound is considered as a freighting issue on physical welfare, which is tough one to cure. Plant based medicaments are advised because of easy accessibility and better wound healing property of compounds [4,5] . India has documented 45,000 series of plants roughly 7500 species reputable as medicinal plants. Earlier system of Indian medicine “Ayurveda” describes healing properties as ‘Vranaropaka’ and treated with medicinal plants [6,7] .
Tinospora Cordifolia: A review of its immunomodulatory properties
Published in Journal of Dietary Supplements, 2022
Charles R. Yates, Eugene J. Bruno, Mary E. D. Yates
As the incidence of and susceptibility to acute and chronic diseases continuously increases, many health-conscious individuals have shifted their mindset from “treatment-centric”, viz., a primary reliance on pharmaceutical interventions, to one that incorporates measures and routines that promote disease prevention and resilience. For example, recent emergent health threats have heightened human awareness of the importance of and need for natural-based modalities that improve health and wellness. In this context, potential candidate botanical preparations are those that both promote a vigorous, well-regulated immune response and mitigate co-morbidities (e.g. diabetes) that weaken the immune system and pre-dispose to either bacterial or viral infection. The ethnomedicine literature including traditional Chinese and Ayurvedic medicine is rife with preclinical and clinical substantiation data that support the immunomodulatory-related structure function claims of herbal preparations derived from numerous well-known medicinal plants such as Echinacea, Curcuma, Camellia, etc. The increased emphasis on human disease prevention and resilience has provided the impetus to explore and highlight additional, lesser-known medicinal plants with purported anti-inflammatory and immunomodulatory activity.
Differential Expression of Platelet Activation Markers, CD62P and CD63, after Exposure to Breast Cancer Cells Treated with Kigelia Africana, Ximenia Caffra and Mimusops Zeyheri Seed Oils In Vitro
Published in Nutrition and Cancer, 2022
Monica N. Gomes, Pascaline Fru, Tanya N. Augustine, Davison Moyo, Eliton Chivandi, William M. U. Daniels
Ethnomedicine has historically been used for the prevention and treatment of various diseases (30). For instance Hodgkin’s lymphoma and leukemia are treated with compounds isolated from the Madagascar periwinkle plants (Vinca rosea) – Vinblastine and Vincristine (31, 32), while Paclitaxel, originally extracted from the bark of the Pacific Yew, Taxus brevifolia Nutt, is frequently used in the treatment of ovarian and breast cancer (32, 33). However the use of some of these herbiceuticals has been controversial. A concern has been raised over a possible Paclitaxel-induced pro-thrombotic risk as a number of reports of thrombotic episodes in cancer patients being treated with this chemotherapy plant alkaloid have been reported (34, 35).
Related Knowledge Centers
- Drug Discovery
- Ethnobotany
- Medical Anthropology
- Medicinal Plants
- Traditional Medicine
- Reverse Pharmacology
- Pharmacognosy
- Herbal Medicine
- Lead Compound
- Medication