Inhibiting the Absorption of Dietary Carbohydrates and Fats with Natural Products
Christophe Wiart in Medicinal Plants in Asia for Metabolic Syndrome, 2017
As a consequence of insulin resistance, postprandial glycaemia in metabolic syndrome is elevated and high concentration of circulating glucose that could be referred to a state of “glucotoxicity” contribute to the development of type 2 diabetes, cardiovascular diseases, and all that cause mortality.19Coptis chinensis Franch. (Figure 1.5) elaborates the alkaloid berberine which when given orally at a dose of 200 mg/kg once daily reduced the glycemia of diabetic rodents and inhibited the enzymatic activity of sucrase and maltase.20 In a clinical study involving type 2 diabetes outpatients, the intake of 500 mg of berberine 3 times daily evoked a reduction in blood glucose.21 Thus, being relatively nontoxic, and poorly absorbed, berberine could conceptually be seen as a potential agent to mitigate glucose absorption in metabolic syndrome.
THE PROGRESS OF CHINESE MEDICINE IN MAINLAND CHINA
Kevin Chan, Henry Lee in The Way Forward for Chinese Medicine, 2001
Acacia catechu (st), Achyranthes bidentata (rt), Act^nitum carmtchaelt (rhz), Alpinia oxyphylla (fr), Alisma orientale (rhz), Allium tuberosum (sd), Amomum villosum (fr), Angelica dahurica (rt), A. sinensis (rt). Andrographis paniculata (pl), Areca catechu (sd), Artabotrys hexapelatus (fl), Artemisia argyi (l), Asparagus cochinchinensis (rt), Aster tataricus (rt), Astragalus mongholicus (rt). Atractylodes macrocephala (rhz), Atropa belladonna (l), Aucklandia lappa (rt), Biota orientale (sd), Brassica juncea (sd), Carthamus tinctorius (fl), Cassia acutifolia (l), C. obtusifolia (sd), Celosia cristat (fl), Chaenomeles speciosa (fr). Cinchona ledgeriana (l), C. grandis (exocarp), Citrus aurantium (fr), C. Medica var. sarcodactylis (fr), C. reticulata (exocarp), Codonopsis pilosula (rt), Coix lacryma-jobi var. ma-yuan (sd), Coptis chinensis (rhz), Cornus officinalis (fr), Corydalis yanhuosu (rhz), Crataegus pinnatifida (fr), Crocus sativus (stigma), Curcuma aromatica (rhz). C. domestica (rhz), C. zedoaria (rhz), Cymbopogon citratus (l), Datura metel (fl), D. innoxia (fl), Dendranthema morifolium (fl), Dendrobium morifolium (fl), Dendrobium nobile (pl), Digitalis lanata (l), Dioscorea opposita (rhz), Dolichos lablab (sd), Eriobotrya japonica (l), Eucalyptus globulus (l), Eucommia ulmoides (bk), Euphorbia longan (aril), Eupatorium fortunei (l), Eurya leferox (sd), Evodia rutaecarpa (fr), Foeniculum vulgare (fr).
Antihypertensive effects of oriental drugs in human and SHR
H. Saito, Y. Yamori, M. Minami, S.H. Parvez in New Advances in SHR Research –, 2020
Coptis chinensis Franch. (ref.A, 1990; ref.9, 1963). A major component of this plant, berberin, decreased blood pressures in anesthetized dogs, cats and rabbits, and also in conscious rats given intravenously or orally. At common or lower doses, an excitation of the heart and an increment of coronary arterial blood flow were observed, but at higher doses heart function was inhibited on the contrary. Although there were many reports related to the antihypertensive effects, both actions of direct vasodilative effect and potentiation on acetylcholine mediated hypotensive effect were generally accepted as its vasodepressant mechanism.
Characterization of hydrocoptisonine metabolites in human liver microsomes using a high-resolution quadrupole-orbitrap mass spectrometer
Published in Xenobiotica, 2020
Su Min Choi, Younah Kim, Jaeick Lee, Ju-Hyun Kim, Taeho Lee, Byung Sun Min, Jeong Ah Kim, Sangkyu Lee
Coptis chinensis belongs to the Ranunculaceae family and is one of the most widely used traditional Chinese medicines. It has attracted much attention because of its multiple pharmacological effects, such as anti-antiviral, anti-inflammatory, and anti-microbial activities, and its ability to dry dampness, treat toxicosis, and detoxify (Commission CP, 2015; Hwang et al., 2006; Lee et al., 2018; Miao et al., 2015; Yu et al., 2005). Hydrocoptisonine is a new protoberberine-type compound isolated from the rhizomes of C. chinensis by our group, previously (Cao et al., 2018) (Figure 1). Although there is no data directly reporting the pharmacological effects of hydrocoptisonine itself, as a newly identified compound, its pharmacological activity will be determined in the future.
Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
Published in Pharmaceutical Biology, 2019
Jin Wang, Lin Wang, Guan-Hua Lou, Hai-Rong Zeng, Ju Hu, Qin-Wan Huang, Wei Peng, Xiang-Bo Yang
Coptis chinensis (Figure 1(A)) is a perennial herb with yellow, branched rhizomes. The leaves are slightly leathery, with three lobes (Xiao 2002). The scapes are 12–25 cm high. In addition, 3–8 flowers are clustered into a dichasium or pleiochasium. The five sepals, 9–12.5 mm in length, 2–3 mm in width, are greenish yellow and oblong ovate. There are approximately 20 stamens with 8–12 carpels, which are slightly curved outside. The 6–12 follicles are 6–8 mm in length with a thin handle. There are 7–8 brown, oblong seeds that are 2 mm long and 8 mm wide. Flowering occurs from February to March, and the fruit is commonly harvested from April to June. It is distributed in Sichuan, Guizhou, Hunan, Hubei, and southern Shaanxi in China. This plant grows in mountain forests or valleys at an altitude of approximately 500–2000 m ( Flora 2004).
Jateorhizine alleviates insulin resistance by promoting adipolysis and glucose uptake in adipocytes
Published in Journal of Receptors and Signal Transduction, 2021
Changqin Cheng, Zhiyong Li, Min Zhang, Dezhi Chen
In the traditional cognition of Chinese medicine, IR patients often present with the syndrome of interior dampness-heat in Chinese medical practice, while the cold property of coptis chinensis can remove the dampness and heat, so coptis chinensis may have a potential therapeutic effect in the treatment of IR [7]. In recent years, traditional Chinese medicine studies have found that coptis chinensis is the most commonly used compound compatibility drug for lowering glucose [8–10]. Coptis chinensis is a perennial herbaceous plant of ranunculaceae, its rhizome has the effect of lowering blood glucose and regulating blood lipid [11], which is mainly related to the pharmacoactive ingredients in the rhizome, including berberine, palmatine, coptisine and so on [12]. Among them, berberine is the most studied rhizoma coptis alkaloid, which has the effect of improving atherosclerosis [13]. Jateorhizine (Jat) is a homologen of berberine, which is also a tetrahydroisoquinoline alkaloid with the similar chemical structure to berberine. Animal experiments have shown that Jat can lower blood glucose level in diabetic mice [14,15]. However, there are few studies on the role of Jat in IR, and the specific mechanism of its hypoglycemic effect is still ambiguous.
Related Knowledge Centers
- Berberine
- Coptis
- Coptisine
- Dye
- Traditional Chinese Medicine
- Species
- Isoquinoline Alkaloids
- Palmatine
- Wool