Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Christophe Wiart in Medicinal Plants in Asia for Metabolic Syndrome, 2017
Caulophine from Caulophyllum robustum Maxim. at a concentration of 0.4 mM protected cardiomyocytes in vitro against hydrogen peroxide with a decrease in creatine kinase, lactate dehydrogenase, malondialdehyde. It increased superoxide dismutase activity and inhibited apoptosis.82 Furthermore, this fluorenone alkaloid given intragastrically to Sprague–Dawley rats at a dose of 25 mg/kg/day for 5 days reduced the occurrence of cardiac infarct by 24.6% induced by ligature of the coronary. It lowered serum creatine kinase, lactate dehydrogenase, and malondialdehyde, whereas superoxide dismutase activity was increased.82 Caulophine at 0.4 mM prophylactically sustained the viability by 95.5% of neonatal rat cardiomyocytes exposed in vitro to caffeine.83 This alkaloid reduced intracellular malondialdehyde and the release of lactate dehydrogenase by myocytes.
Nutraceuticals Impacting Uterine Growth, Gestational Age and Mortality Rate
Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak in Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Blue cohosh or Caulophyllum thalictroides is a small perennial plant that grows mostly in the northeast of American. Native American women were the first to begin brewing the roots as tea, in order to curb the pain associated with menstrual cramps and childbirth (Dugoua et al. 2008). Traditionally, expectant mothers consume blue cohosh with a combination of herbal medicines such as squaw vine, raspberry, black cohosh, and false unicorn, especially during their third trimester called mother’s cordial or partus preparatus. Approximately 64% of the certified nurse midwives in 1999 claimed to use blue cohosh during labor preparation. Even in modern times, in countries like the United States, blue cohosh is frequently utilized as a labor inducer to aid the process of childbirth and make it quick as well as painless for the mother (Dugoua et al. 2008).
Catalog of Herbs
James A. Duke in Handbook of Medicinal Herbs, 2018
Sometimes combined with Caulophyllum thalictroicles and Eupatorium aromaticum, in folk nostrums for female problems, e.g., hysteria, chronic uteritis, or parturition. Amerindians took the herb before confinement in order to render parturition safe and easy. Tierra mentions its use as a wash for sore eyes.28 The herb has also been suggested for amenorrhea, diarrhea, dropsy, dysentery, dysmenorrhea, dysuna, gonorrhea, gravel, hysteria, leucorrhea, menorrhagia, polyuria, uterosis, and vaginitis.283243 It has been called astringent, diuretic, tonic, especially to the uterus. Parvati mentions this as her favorite pregnancy herb, combined with a raspberry and chilled.48 Tierra suggests a combination of partridgeberry, lobelia, raspberry leaves, and wild yam to prevent miscarriage;28 Kloss, the berry tea with olive oil or cream to apply to sore nipples.44 Parvati reports giving to hundreds of women coming off the pill or a pregnancy (either abortion, miscarriage, or nursing) a tea consisting of equal parts of squawvine, black haw, holy thistle, licorice, and sarsaparilla — with positive results. Steep 1 tablespoon of the mixture in a cup, taking 4 to 5 cups the first week, 2 to 3 cups the second week, 1 to 3 cups the third week, tapering off the mere sips in the fourth week. “This may also increase your fertility.”48
Intestinal epithelial damage due to herbal compounds – an in vitro study
Published in Drug and Chemical Toxicology, 2023
Susan M. Britza, Ian F. Musgrave, Rachael Farrington, Roger W. Byard
Other toxic effects of herbs may involve the cardiovascular system with hypertension, arrhythmias, myocardial infarction, and strokes being reported in association with the use of Licorice (Glycyrrhiza glabra (L.)), Ma Huang (Ephedra sinica Stapf) and Blue cohosh (Caulophyllum thalictroides (L.) Michx). Aristochia may cause renal failure, the Sabah plant (Sauropus androgynous (L.) Merr) may cause chronic obstructive pulmonary disease, Kelp (bladder wrack or Fucus vesiculosus (L.)) may cause endocrine disturbances and Jimson weed (Datura stramonium (L.)) has caused seizures (Tovar and Petzel 2009).
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