Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Christophe Wiart in Medicinal Plants in Asia for Metabolic Syndrome, 2017
The glycemia of Swiss albino male rats poisoned with alloxan was reduced by 48%, 6 hours after a single oral administration of 500 mg/kg of an ethanol extract of Aerva lanata (L.) Juss. ex Schult.43 The administration of this extract at the same dose for 15 days to diabetic animals lowered glycemia by 64% and sustained body weight.43 Furthermore, blood urea was reduced from 70 mg/100 mL to 32.1 mg/100 mL and lowered serum peroxide.43 Agrawal et al. provided evidence that a single oral administration of an alkaloid fraction containing canthin-6-one derivatives to streptozotocin–nicotinamide-induced diabetic rats at a dose of 20 mg/kg evoked a reduction of glycemia after 20 hours.44 In a subsequent study, aqueous extract of leaves (containing α-amyrin, betulin, and β-sitosterol) inhibited yeast and rat intestinal α-glucosidase with IC50 values of 81.7 and 108.7 μg/mL, respectively. The extract inhibited dipeptidyl peptidase-IV activity with an IC50 value of 118.62 μg/mL and protein-tyrosine phosphatase-1B with an IC50 value of 94.6 μg/mL.45 This extract at enhanced insulin mediated glucose uptake by 3-fold of basal at 100 μg/mL in L6 myotubes.45 The precise mode of action of this plant is yet unknown but one could make the inference that, at least, it promotes glucose uptake by peripheral tissues. In this context, it must be noted that canthin-6-one derivatives in Aerva lanata (L.) Juss. ex Schult. may possess protein-tyrosine phosphatase-1B inhibitory activities46 improving therefore plasmatic clearance of glucose by skeletal and adipose tissues under insulin influence. Betulin at a concentration of 50 μg/mL increased by 21.4% uptake of glucose by C2C12 myocytes.47
Identification of proper herbs
C. P. Khare in Evidence-based Ayurveda, 2019
Aerva lanata (Linn.) Juss. (Fam. Amaranthaceae) is used in Tamil Nadu, Rotula aquatica Lour. (Boraginaceae) and Homonoia riparia Lour. Syn. Adelia neriifolia Roth. (Euphorbiaceae) are used in Kerala. In Kerala, Aerva lanata is used as Bhadra.
Argyreia nervosa (Samudra pala) leaf extract mediated silver nanoparticles and evaluation of their antioxidant, antibacterial activity, in vitro anticancer and apoptotic studies in KB oral cancer cell lines
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Gunashekar Kalvakunta Subramanyam, Susmila Aparna Gaddam, Venkata Subbaiah Kotakadi, Sashikiran Palithya, Josthna Penchalaneni, Varadarajulu Naidu Challagundla
The fresh aqueous leaf extract has the capability to change silver nitrate solution into an ionic form. In this reaction, the leaf extract reacts with 0.02 mM silver nitrate solution and is changed to dark brown colour (Figure 1(A,B)). The surface plasmon resonance spectrum (SPR) peak of green synthesised An-AgNPs was obtained at 421 nm (Figure 1(C)). In the previous reports on silver nanoparticles synthesised from various plants extracts, the SPR band was noticed to increase the intensity with an increase in time intervals and concentration of AgNO3 from 0.001 M to 0.005 M. Similarly, green synthesised AgNPs showed similar results with different plant extract like leaf extract Artemisia annua, Boerhavia erecta, Decaschistia crotonifolia, Fruit Extract of Solanum nigrum, Momordica charantia, Garlic clove, seed Extracts of Nigella sativa and flower extracts of Aerva lanata, rapeseed flower pollen extract, palm pollen extract and sumac extract mediated silver nanocomposites and so on [24–35].
Green Fabrication of silver nanoparticles by leaf extract of Byttneria Herbacea Roxb and their promising therapeutic applications and its interesting insightful observations in oral cancer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2023
Gunashekar Kalvakunta Subramanyam, Susmila Aparna Gaddam, Venkata Subbaiah Kotakadi, Hema Gunti, Sashikiran Palithya, Josthna Penchalaneni, Varadarajulu Naidu Challagundla
The UV visible data proved that the aqueous leaf extract of Byttneriea herbacea has capability to change 0.02 M silver nitrate solution into the ionic form Ag+, the diluted colourless leaf extract reacts with 0.02 M silver nitrate solution and reduce to ionic form Ag+ to Ag0 which is confirmed by the colour change of the solution to dark brown colour (Figure 1B(a–b)). The surface plasmon resonance spectrum (SPR) peak of biosynthesized BH-AgNPs was obtained at 422 nm, the same sample was read after 30 min revealed the SPR at 437 nm (Figure 1(C)). The results were similar to the previous reports on the green synthesis of silver nanoparticles from various plants extracts, the SPR peak was reported to increase its intensity with an increase in time intervals and concentration of AgNO3 from 0.001 M to 0.005 M. Likewise, the biosynthesized AgNPs by different plant extract like leaf extract Boerhavia erecta, Artemisia annua, Decaschistia crotonifolia, and flower extracts of Aerva lanata and Ferulago macrocarpa [15, 43–46] revealed similar results.