Cardiac Performance During Diabetes
Grant N. Pierce, Robert E. Beamish, Naranjan S. Dhalla in Heart Dysfunction in Diabetes, 2019
Another method used to prevent the decline in cardiac performance during diabetes was vanadate treatment. Vanadate is the oxidized form of the trace element vanadium. It has an insulin-like action in the cell.92 Vanadate, when included in the drinking water of diabetic rats, restored plasma glucose levels to control without influencing plasma insulin concentration.93 The left ventricular developed pressure and + and -dP/dt were significantly depressed in the diabetic animals. After vanadate treatment, these functional parameters were normalized in the diabetic rats. Unfortunately, side effects may limit its clinical usefulness, at least in the near future. Since cardiac dysfunction recovered without any improvement in plasma insulin concentrations but with a dramatic improvement in blood sugar levels, this would support a role for hyperglycemia and not hypoinsulinemia in the cardiac disease. However, the validity of this contention is complicated and seriously threatened by the knowledge that the molecular mode of action of vanadate is very much like that of insulin.92
Vanadium
Linda M. Castell, Samantha J. Stear (Nottingham), Louise M. Burke in Nutritional Supplements in Sport, Exercise and Health, 2015
At supraphysiological levels, in vitro and animal studies indicate that vanadate and other vanadium compounds exert measurable biological effects (Rehder, 2012). Effects on glucose transport activity and pancreatic β-cell function, via phosphatases and kinases, are currently the subject of research into antidiabetic therapeutics (Smith et al., 2008). The role of vanadium as a transcription modulator of genes in oxidative stress and oncogenesis has also been described (Willsky et al., 2006; Manna et al., 2011) in studies investigating anti-cancer agents.
V
Anton Sebastian in A Dictionary of the History of Medicine, 2018
Vanadium Element discovered in 1801 by Spanish mineralogist, Andrés Manuel Del Rio (1764–1849) of Madrid. Swedish physician and chemist, Nils Gabriel Sefström (1765–1829) in 1830 named it after the Scandinavian goddess, Freya Vanadin. It was isolated in Cheshire mines by English chemist, Sir Henry Enfield Roscoe (1833–1915) in 1865. It is used to make a steel alloy. Its anhydride was shown to be a strong respiratory irritant by F. Molfino in 1938. Vanadium poisoning due to its toxic dust was described by H. Synmanski in 1939.
Serum trace element and heavy metal levels in patients with sepsis
Published in The Aging Male, 2020
İdris Akkaş, Nevin Ince, Mehmet Ali Sungur
Nickel (Ni), which is one of the trace elements that are considered carcinogenic for humans, can be included in the enzyme structure that contributes to the virulent behavior of certain bacteria such as Helicobacter pylori [12]. Cadmium (Cd) is another well-known carcinogenic trace element [13]; however, to the best of our knowledge, serum Cd levels in cases of infection have not yet been studied. Aluminum (Al) is considered to be responsible for cell death due to irreversible structural changes in protein structures in Alzheimer’s disease [14]. To date, to the best of our knowledge, no human studies have been conducted on Vanadium (V), which is included in the possibly essential trace element category. However, in vitro and in vivo studies have shown that the use of V may be beneficial in the treatment of viral and bacterial infections as well as cardiovascular and neurological disorders [15].
The impact of concomitant administration of vanadium and insulin on endothelial dysfunction markers (PAI-1 and ET-1) in type 1 diabetic rats
Published in Archives of Physiology and Biochemistry, 2021
M. D. Morsy, I. Bin-Jaliah, S. O. Bashir, A. Shatoor, M. A. Haidara
Several researchers reported that the endothelial complications in diabetes occurs in spite of proper glycaemic control. Several attempts try to find a supportive therapeutic agent to insulin, especially in type 1 diabetes to avoid endothelial vascular complications. Vanadium is a trance element that is widely distributed in nature and present in the animals and human at a minimal concentration (Shurtz-Swirski et al.2001). Metavanadate is the most common form of vanadium in the extracellular fluids, whereas, the most prevalent intracellular is the vanadyl (Panchal et al.2017). Its oral administration has been reported to improve DM type-1 and -2 in humans and also acts in synergism with insulin to protect against the development of diabetic complications (Wu et al.2012). Glucose intolerance was completely improved, hepatic triacylglycerol (TG) content decreased, width of subcutaneous fat decreased and body weight decreased by 20% in fatty Zucker rats treated with an oxovanadium (Metelo et al.2012). So, the aim of the present study was to investigate the preventive role of concomitant administration of insulin and vanadium on oxidative stress and endothelial dysfunction makers in type one diabetes mellitus.
Microwave extraction of Salvia officinalis essential oil and assessment of its GC-MS identification and protective effects versus vanadium-induced nephrotoxicity in Wistar rats models
Published in Archives of Physiology and Biochemistry, 2019
Fatma Ghorbel Koubaa, Raed Abdennabi, Ahlem Soussi Ben Salah, Abdelfattah El Feki
Vanadium present in living organisms including humans in very small amounts. This metal has not been shown to be essential for humans and has no nutritional value. In large doses, vanadium is toxic and causes a wide variety of adverse hazards to health. An important, new use of vanadium is its massive inclusion in car batteries with consequent environmental and disposal problems. Therefore, this metal is of continuing biological, industrial, and occupational concern (Tracey and Willsky 2007). The environmental pollution, due to vanadium, is a potential health threat since soluble vanadium salts within μM and mM range were found to exert adverse effects mainly on liver and kidney (Domingo et al.1991). Several biological studies associate vanadium with the ability to produce high concentrations of reactive oxygen species (ROS) that are important mediators of damage to cell structures, including lipids and, therefore, membranes, proteins, and nucleic acids (termed oxidative stress). The oxidative stress results in alterations of antioxidant enzymes (Elfant and Keen 1987), the diminution of non-enzymatic antioxidants (like vitamin C and non-protein thiols such as glutathione) (Shi et al.1990) which consequently leads to lipid peroxidation (Zhang et al.2003).