Nutraceutical Herbs and Insulin Resistance
Robert E.C. Wildman, Richard S. Bruno in Handbook of Nutraceuticals and Functional Foods, 2019
Konjac extract (KE) was refined from Amorphophallus konjac K.Koch, a kind of Chinese herb. KE is a kind of white crystal grain obtained from its tuber. Its main component is Konjac glucomannan,11 which is a kind of excellent edible fiber. It was reported12,13 that this polysaccharide could decrease total cholesterol (TC) and blood glucose, fat, and excretion. Recent studies indicated that KE could obviously improve glucose tolerance in diabetic patients and animals.14 This was confirmed by Mao et al, who showed that KE might not only improve insulin resistance and increase insulin sensitivity, but also lower fasting plasma glucose (FPG) and glycogen in liver and skeletal muscle, but it had no effect on the release of insulin. The experimental results revealed that KE might improve insulin sensitivity by increasing glucose usage of non-oxidation approach, not depending on the release of insulin.15
Role of Natural Agents in the Management of Diabetes
Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg in Promising Drug Molecules of Natural Origin, 2020
Traditionally, konjac is used in China, Japan, and Southeast Asia as a food and medicinal product. The main component of crude konjac is glucomannan, which is a 100% water-soluble DF derived mainly from the tuberous roots of this plant (Cheang et al., 2017). The glucomannan fiber cannot be hydrolyzed by salivary and pancreatic amylase (Chua et al., 2010).
Potential applications of drug delivery technologies against radiation enteritis
Published in Expert Opinion on Drug Delivery, 2023
Dongdong Liu, Meng Wei, Wenrui Yan, Hua Xie, Yingbao Sun, Bochuan Yuan, Yiguang Jin
Konjac glucomannan (KGM) is a water-soluble polysaccharide obtained from the roots and tubers of konjac plants. KGM consists of D-mannose and D-glucose with an α-1,4-pyranoside bond and a small number of acetyl groups at the C-6 position of the side chain. KGM is biodegradable, non-toxic, harmless, and biocompatible. Its gelation performance is one of its most significant characteristics and enables wide applications of KGM hydrogels as drug delivery systems [103]. KGM can only be hydrolyzed by α-mannase at the end of the small intestine and the colon of the human body, so KGM hydrogels released drugs in the gut for RE therapy.
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