Biological Effects of Ayurvedic Formulations
D. Suresh Kumar in Ayurveda in the New Millennium, 2020
Caraka was the first author to mention Cyavanaprāśa. He explains that it is the rasāyana par excellence. It is an excellent rejuvenator with the ability to delay aging and enhance general well-being. It is effective in cardiovascular diseases, cough, dyspnea, rheumatic diseases, hoarseness of voice and impotence. It promotes intellect as well (Sharma 1983b). The major ingredient of Cyavanaprāśa is gooseberry (Emblica officinalis), which is a known antioxidant and rich source of vitamin C (Parle and Bansal 2006). The primary action of Cyavanaprāśa is to strengthen the immune system and to support the body’s natural ability to produce hemoglobin and white blood cells (Pole 2006). As a result, it is reputed as a highly admired rasāyana, offering deep nourishment to tissues, preserving youthfulness and promoting systemic health and well-being.
Anti-Hyperglycemic Property Of Medicinal Plants
Amit Baran Sharangi, K. V. Peter in Medicinal Plants, 2023
Emblica officinalis with a vernacular name Indian Gooseberry or Amla, belongs to Phyllanthaceae family and natively from Indian Subcontinent. In one study aqueous extract of fruits of amla showed improvement in OGTT in insulin independent hyperglycemic rats after four weeks of feeding and remarkable decrease in FBG levels after 8 weeks (Ansari et al., 2014). In another study, methanolic extract of E. officnialis consists of quercetin and quercetin was found to be a major contributing factorin reduction of blood glucose level by 14.78% (0.075 g/kg) after one week of treatment. Quercetin extracted from methanolic extract also improved HDL, LDL, triglycerides, and total cholesterol levels at a dose of 0.05 and 0.075 g/kg body weight (Srinivasan et al., 2018).
Arsenic Toxicity
Charles Theisler in Adjuvant Medical Care, 2023
Ascorbic Acid: Arsenic induced hepatotoxicity has been reported by recent experimental studies which have suggested that vitamin C supplementation improves mitochondrial structure and function, along with restriction of apoptosis due to caspase-3 inhibition in arsenic trioxide exposed rat liver. The overall report suggests that vitamin C and vitamin C-rich fruits such as gooseberry provide protection against metal induced hepatotoxicity.4
Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model
Published in Archives of Physiology and Biochemistry, 2023
Victor Hugo Dantas Guimarães, Deborah de Farias Lelis, Luis Paulo Oliveira, Luciana Mendes Araújo Borém, Felipe Alberto Dantas Guimarães, Lucyana Conceição Farias, Alfredo Mauricio Batista de Paula, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos
In conclusion, we observed that the use of combined high-fat and high-sugar diets is efficient to induce obesity and metabolic disorders in mice. Among the tested diets, the high-lard/high-sugar (HLHS) diet changed the greatest number of parameters, thus is a strong choice to induce metabolic syndrome associated alterations. Furthermore, by adding high-sugar syrup (80%) flavored with gooseberry, a simple sugar commonly used in the food industry, the metabolic alterations were preserved. In addition, we observed an increased food intake, possibly due to the improvement in palatability that inhibits the self-regulating haemostatic mechanism of caloric intake, which in turn seems to be inhibited to the detriment of the reward system activation (Saper et al.2002, Erlanson-Albertsson 2005). Sucrose and fructose is a highly lipogenic monosaccharide that promotes metabolic disorders, such as insulin resistance, impaired glucose metabolism, dyslipidemia, and hepatic steatosis, as well as both cardiac and renal dysfunction (Stanhope et al.2009, DiNicolantonio et al.2016). Altogether, these findings indicate that the HLHS + high-sugar syrup (80%) flavored with gooseberry diet model was efficient to induce several obesity-associated characteristics.
The Prevention and Therapy of Osteoporosis: A Review on Emerging Trends from Hormonal Therapy to Synthetic Drugs to Plant-Based Bioactives
Published in Journal of Dietary Supplements, 2019
Twinkle Gupta, Nilanjan Das, Sabiha Imran
Indian gooseberry (Emblica officinalis) is a deciduous tree belonging to the family Euphorbiaceae. Among its properties are antitussive, antiatherogenic, renoprotective, and neuroprotective activity (Baliga & Dsouza, 2011; Shanker, 1969; Mirunalini & Krishnaveni, 2010). Extracts of Emblica officinalis fruits possess free radical–scavenging properties and are thus studied for possible treatments of diseases such as osteoporosis and rheumatoid arthritis (Penolazzi et al., 2008). E. officinalis extract does not have inhibitory effects on the development of tartrate-resistant acid phosphatase (TRAP) (Ullmann, Bendik, & Flühmann, 2005) and does not cause any cytotoxic effects. The ability of E. officinalis extract to interfere with NF-kB binding to DNA has also been investigated. It has been found that the extract of E. officinalis is a strong inducer of apoptosis of osteoclasts. Moreover, it is also found that extract of E. officinalis possesses a similar inhibitory effect on human cells as biphenylcarboxylic acid, butanediol ester, and genistein.
Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
Published in Nutrition and Cancer, 2022
Gaurav Kumar, Venkateshwar Madka, Gopal Pathuri, Vishal Ganta, Chinthalapally V. Rao
Three clinical trials (Table 3) are currently listed at www.clinicaltrials.gov, they respectively study the effectiveness of Indian gooseberry in hypercholesterolemia, metabolic syndrome, and periodontitis. Many other clinical trials assessing its effectiveness in multiple diseases, either alone or in combination with standard treatments, are listed on the clinical trials registry of India. Clinical trials using gooseberry extract, based on searches of www.clinicaltrials.gov, the clinical trials registry of India, and PubMed, are listed in Table 4. Although human evidence of efficacy of P. emblica alone is limited, its use in combination with standard treatments has been demonstrated effective in various clinical trial phases. While there are no active trials listed that focus on clinical intervention using P. emblica in cancer patients, data from other trials suggest it may prevent tumors by reducing cancer promoting risk factors. In humans, P. emblica has been shown to reduce levels of various fat components, such as cholesterol, lipids, LDL, and triglycerides. Clinical data suggest that fresh fruit extract of Indian gooseberry: (a) significantly decreased the total cholesterol, triglycerides, lipids, and low-density lipoprotein-cholesterol levels and improved the high-density lipoprotein-cholesterol in both normal and diabetic volunteers (52); (b) significantly improved endothelial function and reduced biomarkers of oxidative stress and systemic inflammation in patients with type 2 diabetes mellitus, without any significant changes in laboratory safety parameters (55); (c) reduced oxidative stress in uremic patients (54); and (d) lowered multiple risk factors associated with cardiovascular disease in overweight adults (57). Notably, clinical trials of different gooseberry phytochemicals, such as ellagic acid, quercetin, vitamin C, chlorogenic acid, and coumaric acid, individually and combined with other phytochemicals, have been explored and demonstrated to be effective in many diseases, such as hypertension, cardiovascular disease, and cancer.
Related Knowledge Centers
- Acid
- Animal
- Fever
- Pubic Hair
- Ribes
- Berry
- Fruit
- Pharmacology
- Cotton
- Pie