Thickening Agents
Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters in Cosmetic Formulation, 2019
Fumed silica is a synthetic, amorphous, colloidal silicon dioxide. It is an inorganic thickener with a wide variety of cosmetics and personal care applications. With fumed silica, cosmetic oils can easily be converted into highly viscous, largely transparent gels. There are some modified silica with hydrophobic properties which are perfect for creating or adjusting thixotropic properties, improving suspension without significantly increasing viscosity, and imparting stability and water-resistance to emulsions, especially for sunscreen and makeup formulations.
Dry-Fill Formulation and Filling Technology
Larry L. Augsburger, Stephen W. Hoag in Pharmaceutical Dosage Forms, 2017
Hogan et al.9 investigated the relationship between drug properties, filling parameters, and release of drugs from hard gelatin capsules using multivariate statistical analysis. They concluded that the optimum concentration for Aerosil (colloidal silica) appears to be 1%, with respect to both coefficient of fill weight variation and flowability, as measured by Carr’s CI.
Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate
Published in Pharmaceutical Development and Technology, 2022
Daniel Zakowiecki, Tobias Hess, Krzysztof Cal, Barbara Mikolaszek, Grzegorz Garbacz, Dorota Haznar-Garbacz
Rosuvastatin calcium EP was purchased from Cadchem Laboratories Limited (Chandigarh, India) with very fine particles (≥90% below 13 µm) and water content ≈5.6%. Tribasic calcium phosphate fine powder (TCP fine): TRI-CAFOS® 200-7 with a medium particle size ≈4 µm, coarse tribasic calcium phosphate (TCP coarse): TRI-CAFOS® 500 with a medium particle size ≈100 µm, anhydrous dibasic calcium phosphate of acidic pH (DCPA(A)): DI-CAFOS® A150 with a medium particle size ≈150 µm, and anhydrous dibasic calcium phosphate neutral (DCPA(N) with a medium particle size ≈120 µm were manufactured by Chemische Fabric Budenheim KG (Budenheim, Germany). Microcrystalline cellulose (MCC): Heweten® 102 with a medium particle size ≈130 µm was purchased from JRS Pharma (Rosenberg, Germany). α-Lactose monohydrate: Tablettose® 100 with a median particle size ≈125 µm was manufactured by Meggle Group (Wasserburg, Germany). Fumed silica: Aerosil® 200 from Evonik (Rheinfelden, Germany). Low-substituted hydroxypropyl cellulose (L-HPC): LH-11 was purchased from ShinEtsu (Wiesbaden, Germany). Magnesium stearate: Ligamed® MF-2-V was purchased from Peter Greven Fett-Chemi (Venlo, The Netherlands). Film-coating system: AquaPolish® P pink 640.20 PVA was produced by Biogrund (Huenstetten, Germany). Crestor® 5 mg, 10 mg, 20 mg, and 40 mg film-coated tablets were used as a reference product (AstraZeneca UK Ltd., Luton, UK).
Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid
Published in Drug Development and Industrial Pharmacy, 2020
Dipanjoy Ghosh, Sachin Kumar Singh, Rubiya Khursheed, Narendra Kumar Pandey, Bimlesh Kumar, Rajan Kumar, Yogita Kumari, Gurmandeep Kaur, Ayinkamiye Clarisse, Ankit Awasthi, Monica Gulati, Subheet Kumar Jain, Omji Porwal, Esra Bayrakdar, Muath Sheet, K. Gowthamarajan, Saurabh Gupta, Leander Corrie, Pradnya Gunjal, Rajneesh Kumar Gupta, Thakur Gurjeet Singh, Shibanand Sinha
These challenges associated with liquid SNEDDS (L-SNEDDS) can be overcome by their solidification. This is accomplished either by their direct adsorption onto the solid carriers such as silica and lactose, melt extrusion or by spray drying technique. It is important to note that L-SNEDDS of DHA have been reported by Puri et al. [14] and solid SNEDDS (S-SNEDDS) by Singh et al. [15] using hydrophilic solid carriers. The reported formulations have shown excellent stability as well as therapeutic efficacy. In this manuscript, we have reported the formulation with hydrophobic adsorbents as well as screening of various oils to achieve optimized SNEDDS formulation. Impact of various hydrophilic and hydrophobic carriers on micromeritic properties and stability of developed formulation has also been discussed. This screening was considered to be significant due to liquid nature of DHA. Moreover, it is added in an isotropic mixture of oils and liquid surfactants. Hence, to solidify DHS-SNEDDS, more amount of hydrophilic carrier is required which, in turn, increases total weight of the formulation making it cumbersome to administer such high dose. Hydrophobic carriers such as aerosil or, other silica are known for excellent adsorption and flow properties due to very large surface area. This could offer solid DHA-SNEDDS using less amount of carrier with better flow properties. Hence, in the present study, an attempt has been made to develop S-SNEDDS of DHA in order to improve its solubility, dissolution rate, and physico-mechanical stability.
Development of stabilized tenofovir disoproxil tablet: degradation profile, stabilization, and bioequivalence in beagle dogs
Published in Drug Development and Industrial Pharmacy, 2018
Ga-Hui Oh, Joo-Eun Kim, Young-Joon Park
After a two-month storage at 40 °C/75% RH, binary mixtures of TD and the excipients were evaluated using HPLC. As shown Figure 4, the hydrophilic fumed silica (Aerosil® 300) and MCC (Heweten® 102) adversely increased the decomposition of TD. For the colloidal silicon dioxide products used, Aerosil® 300 is a hydrophilic dispersed colloidal silicon dioxide, whereas Aerosil® R972 is hydrophobic [25]. A previous study revealed that hydrophobic colloidal silicon dioxide reduced the water uptake of powders stored under all humidity levels while the hydrophilic forms adsorb water at higher humidity levels [26]. Similarly, MCC has the limitation of inducing instability in moisture-sensitive drugs owing to its hygroscopic property. The moisture content alone indicates little about the characteristics of an excipient under hydrolysis [27]. The moisture content of Vivapur® 112 (<1.5%) is lower than that of Heweten® 102 (<6%) [28]. The compatibility results show that TD was incompatible with hygroscopic excipients, which increased its hydrolysis by adsorption around the moisture. It showed that TD exhibited the best stability when SB and non-hygroscopic excipients were used as the tablet stabilizer and diluents, respectively.
Related Knowledge Centers
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