Adaptation to Intermittent Hypoxia and its use for Protecting the Heart from Stress and Ischemic Damage
Felix Z. Meerson, Alexander V. Galkin in Adaptive Protection of The Heart: Protecting Against Stress and Ischemic Damage, 2019
Table 14 lists the cumulative number of extrasystoles in 24 h for each individual case, and demonstrates the effect of adaptation on these rhythm disorders. As can be seen, when the relative changes are averaged, adaptation to intermittent hypoxia decreases the number of both ventricular and supraventricular extrasystoles about threefold. The antiarrhythmic effect is more pronounced in men: ventricular extrasystoles are reduced by 82 ± 4% (p < 0.001) vs. 47 ± 15% (p < 0.05) in women, and the pattern is much the same with supraventricular extrasystoles. When the day and the night periods are analyzed separately, ventricular extrasystole is more affected during the day (86 ± 8% in men and 63 ± 10% in women); the effect on supraventricular extrasystole is about the same in either period. It is noteworthy that adaptation suppresses group extrasystole, which is the most grave form in this contingent: it was completely abolished in 3 out of 5 patients and reduced more than by half in the fourth. There was a single case when despite some reduction of ventricular extrasystole the number of group extrasystoles increased; this turned out to be due to a marked (more than 10-mm) mitral valve prolapse, which appears to be a contraindication against adaptation to hypoxia in the altitude chamber.
Diabetes Mellitus and Ischemic Heart Disease
E.I. Sokolov in Obesity and Diabetes Mellitus, 2020
The development of pronounced tachycardia is an important disorder in the cardiovascular system in DM. This is why most of the DM patients complain of tachycardia and arrhythmia. The pathogenesis of these phenomena is associated, on the one hand, with an increased number of circulating catecholamines, and on the other with the presence of neuropathy [102, 179, 190, 198, 201, 256]. Lesion of the parasympathetic section of the vegetative nervous system facilitates the appearance of all these changes. Seizures of paroxysmal tachycardia appear especially frequently in DM patients. Their frequency grows in the period of the development of hypoglycemia or in orthostatic hypertension produced by neuropathy. Ketoacidosis and disturbance of electrolytic metabolism are an important cause of the disorders. These factors facilitate the development of disorders such as ventricular extrasystole, ciliary arrhythmia, intraventricular and atrioventricular blockades. All these disorders of rhythm and conduction are typical of DM.
Effect of coenzyme Q10 on the malondialdehyde level and exercise performance of male runners in Jakarta
Elida Zairina, Junaidi Khotib, Chrismawan Ardianto, Syed Azhar Syed Sulaiman, Charles D. Sands, Timothy E. Welty in Unity in Diversity and the Standardisation of Clinical Pharmacy Services, 2017
We first selected 25 middle- and long-distance male runners, of whom 9 were excluded for not meeting the age criteria. The remaining 16 runners were randomized and divided into Coenzyme Q10 supplemental and placebo groups. VO2 max measurement was performed by all participants. At seven days after that, all participants performed the strenuous exercise test according to their test intensity. One participant from placebo group had to stop his participation in the study because of extrasystole finding on the ECG during the strenuous exercise test. The remaining participants successfully completing the trial. However, data from two participants were excluded from exercise performance analysis, because they committed a violation of procedure.
A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia
Published in Current Medical Research and Opinion, 2021
Ying Li, Demei Zhu, Yiqiang Peng, Zhaohui Tong, Zhuang Ma, Jinfu Xu, Shenghua Sun, Huaping Tang, Qingyu Xiu, Yongjie Liang, Xiongbiao Wang, Xiaoju Lv, Yuanrong Dai, Yingqun Zhu, Yuejin Qu, Kaifeng Xu, Yijiang Huang, Shiman Wu, Guoxiang Lai, Xi Li, Xiaowen Han, Zegang Yang, Jifang Sheng, Zhuola Liu, Hui Li, Yiqiang Chen, Huili Zhu, Yingyuan Zhang
Drug-related AEs in this study included clinical AEs, laboratory abnormalities and abnormal ECG findings. In the sitafloxacin 100 mg qd group, the incidence of drug-related clinical AEs was 16.4% (19/116); the most frequently reported one was dizziness (4.3%). The incidence of drug-related laboratory abnormalities was 8.6% (10/116), mainly increased platelet count (2.6%). Drug-related abnormal ECG finding (sinus arrhythmia) was found in 2 patients. In the sitafloxacin 100 mg bid group, the incidence of drug-related clinical AEs was 20.2% (23/114), mainly nausea and diarrhea (both 3.5%). The incidence of drug-related laboratory abnormalities was 12.3% (14/114), mainly ALT elevation (7.0%), followed by AST elevation and γ-glutamyltransferase increase (both 2.6%). Drug-related abnormal ECG findings were found in 2 patients (sinus bradycardia, supraventricular extrasystole). In the moxifloxacin group, the incidence of drug-related clinical AEs was 20.9% (23/110), mainly nausea (8.2%), dizziness (5.5%), fatigue (4.5%) and vomiting (3.6%). The incidence of drug-related laboratory abnormalities was 8.2% (9/110), mainly AST elevation (3.6%) and ALT elevation (2.7%). Drug-related abnormal ECG findings (sinus bradycardia) were found in 3 patients (Table 6).
Percutaneous closure of a secundum atrial septum defect performed under hypnosis: a case report
Published in Acta Cardiologica, 2021
I. Vanreusel, S. Maes, D. De Wolf, A. Van Berendoncks
A 66 year old female patient with medical history consisting of Crohn's disease, arterial hypertension, hysterectomy, varicetomy as well as a restrictive pulmonary disease due to severe deformative torsional scoliosis (Figure 1) was admitted in October 2018 at the cardiology department of the University Hospital of Antwerp (UZA) to perform a percutaneous ASD closure. Indication for ASD closure was reduced exercise tolerance and dyspnoea. In 2016, an ASD secundum with left-right shunt (Figure 2) was discovered in this patient, resulting in right ventricle overload and increased pulmonary pressures during exercise. In addition, the patient was also found to have a significant ventricular extrasystole (VES) burden, mainly monomorphic with right bundle branch block (RBBB) morphology.
Obstructive sleep apnea and cardiovascular events in elderly patients
Published in Expert Review of Respiratory Medicine, 2022
Pablo Catalan Serra, Xavier Soler
Studies performed in adults show a strong association between AF and OSA [90,91,94], more significant than other traditional OSA risk factors, such as obesity, hypertension, or diabetes [95]. Mehra et al. found in the cohort of SHHS that severe OSA increased the risk of atrial fibrillation, ventricular tachycardia, and ventricular extrasystole [90]. A subsequent study by the same author, which included almost 3,000 patients, found that the more severe the OSA, the higher the risk of atrial fibrillation and extrasystole ventricular in elderly patients. When analyzing obstructive and central sleep apnea separately, the authors observed that the increase in the severity of predominantly OSA was significantly associated with an increase in ventricular extrasystole, but not with atrial fibrillation. Central sleep apnea was more associated with atrial fibrillation than with extrasystole [65]. A causal, temporal relationship of respiratory events preceding paroxysms of AF was found on a case-crossover design [96], suggesting that episodes of upper airway compromise may lead to proximate arrhythmia generation.
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